Production Method 1

771-61-9

35661-40-6

86060-92-6

Reaction Conditions

1.1 Reagents: 4-Methylmorpholine ,  9-Fluorenylmethyl chloroformate ;  10 min, -15 °C
1.2 Solvents: Tetrahydrofuran ;  -15 °C → rt

Reference

9-Fluorenylmethyl chloroformate (Fmoc-Cl) as a useful reagent for the synthesis of pentafluorophenyl, 2,4,5-trichlorophenyl, pentachlorophenyl, p-nitrophenyl, o-nitrophenyl and succinimidyl esters of Nα-urethane protected amino acids

Tantry, Subramanyam J.; Babu, Vommina V. Suresh, Letters in Peptide Science, 2004, 10(5-6), 655-662

Production Method 2

14533-84-7

35661-40-6

86060-92-6

Reaction Conditions

Reference

Preparation of pentafluorophenyl esters of Fmoc protected amino acids with pentafluorophenyl trifluoroacetate

Green, Michael; Berman, Judd, Tetrahedron Letters, 1990, 31(41), 5851-2

Production Method 3

26346-84-9

35661-40-6

86060-92-6

Reaction Conditions

1.1 Reagents: Pyridine

Reference

Bis(pentafluorophenyl) sulfite as a new reagent for the preparation of pentafluorophenyl (activated) esters of N-protected amino acids

Il'ina, A. V.; Davidovich, Yu. A.; Rogoshin, S. V., Izvestiya Akademii Nauk SSSR, 1988, (12), 2816-18

Production Method 4

771-61-9

35661-40-6

86060-92-6

Reaction Conditions

1.1 Reagents: Dicyclohexylcarbodiimide Solvents: Ethyl acetate ;  2 h, 0 °C

Reference

Pentafluorophenol

Jones, Keith; DeAmicis, Carl, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2009, 1, 1-9

Production Method 5

771-61-9

35661-40-6

86060-92-6

Reaction Conditions

1.1 Reagents: Dicyclohexylcarbodiimide Solvents: Ethyl acetate

Reference

9-Fluorenylmethyl pentafluorophenyl carbonate as a useful reagent for the preparation of N-[(9-fluorenylmethoxy)carbonyl] amino acids and their pentafluorophenyl esters

Schon, Istvan; Kisfaludy, Lajos, Synthesis, 1986, (4), 303-5

Fmoc-Phe-OPfp Raw materials

• Benzene, 1,1'-sulfinylbis[2,3,4,5,6-pentafluoro-
• Pentafluorophenyl trifluoroacetate
• Pentafluorophenol
• Fmoc-Phe-OH

Fmoc-Phe-OPfp Preparation Products

• Fmoc-Phe-OPfp (86060-92-6)

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• Solvents and Organic Chemicals Organic Compounds Acids/Esters

• 86060-90-4(Fmoc-Pro-OPfp)
• 86061-00-9(Fmoc-Gln-Opfp)
• 125281-38-1(Fmoc-D-Pro-OPfp)
• 121593-77-9(Fmoc-Nle-OPfp)
• 123180-69-8(Fmoc-ORN(BOC)-OPFP)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)