Production Method 1

771-61-9

103321-52-4

86060-90-4

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: Dichloromethane ,  Water

Reference

Synthesis of pentafluorophenyl, 2,4,5-trichlorophenyl and pentachlorophenyl esters of Fmoc-amino acids using Fmoc-amino acid chlorides as intermediates

Babu, Vommina V. Suresh; Ananda, Kuppanna; Mathad, Raveendra I., Letters in Peptide Science, 2001, 7(4), 239-242

Production Method 2

771-61-9

71989-31-6

86060-90-4

Reaction Conditions

1.1 Reagents: Dicyclohexylcarbodiimide Solvents: Ethyl acetate ;  2 h, 0 °C

Reference

Pentafluorophenol

Jones, Keith; DeAmicis, Carl, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2009, 1, 1-9

Production Method 3

771-61-9

71989-31-6

86060-90-4

Reaction Conditions

1.1 Reagents: Dicyclohexylcarbodiimide Solvents: Ethyl acetate

Reference

9-Fluorenylmethyl pentafluorophenyl carbonate as a useful reagent for the preparation of N-[(9-fluorenylmethoxy)carbonyl] amino acids and their pentafluorophenyl esters

Schon, Istvan; Kisfaludy, Lajos, Synthesis, 1986, (4), 303-5

Production Method 4

771-61-9

71989-31-6

86060-90-4

Reaction Conditions

1.1 Reagents: Thionyl chloride Solvents: Dichloromethane
1.2 Reagents: Pyridine Solvents: Tetrahydrofuran

Reference

A new facile one-pot preparation of pentafluorophenyl and 3,4-dihydro-4-oxo-1,2,3-benzotriazine-3-yl esters of Fmoc amino acids

Jakobsen, Mogens Havsteen; Buchardt, Ole; Engdahl, Tom; Holm, Arne, Tetrahedron Letters, 1991, 32(43), 6199-202

Fmoc-Pro-OPfp Raw materials

• Pentafluorophenol
• 1-Pyrrolidinecarboxylicacid, 2-(chlorocarbonyl)-, 9H-fluoren-9-ylmethyl ester, (2S)-
• Fmoc-Pro-OH

Fmoc-Pro-OPfp Preparation Products

• Fmoc-Pro-OPfp (86060-90-4)

• 1. Aggregation-induced chiral symmetry breaking of a naphthalimide–cyanostilbene dyad?
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• 2. Alternative synthesis of the anti-baldness compound RU58841?
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• 3. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
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• 4. Achieving excellent anti-corrosion and tribological performance by tailoring the surface morphology and chemical composition of aluminum alloys
  Wenjie Zhao,Hua Hou,Yuchun Jin,Zhixiang Zeng,Xuedong Wu,Qunji Xue RSC Adv., 2014,4, 60307-60315
• 5. Aggregation-induced emission of luminol: a novel strategy for fluorescence ratiometric detection of ALP and As(v) with high sensitivity and selectivity?
  Yuan-Jun Tong,Lu-Dan Yu,Lu-Lu Wu,Shu-Ping Cao,Ru-Ping Liang,Li Zhang,Xing-Hua Xia,Jian-Ding Qiu Chem. Commun., 2018,54, 7487-7490

• Solvents and Organic Chemicals Organic Compounds Acids/Esters

• 86061-00-9(Fmoc-Gln-Opfp)
• 125281-38-1(Fmoc-D-Pro-OPfp)
• 121593-77-9(Fmoc-Nle-OPfp)
• 123180-69-8(Fmoc-ORN(BOC)-OPFP)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)