Production Method 1

437-81-0

85118-00-9

Reaction Conditions

1.1 Reagents: Sodium borohydride Solvents: Methanol ;  1 h, rt
1.2 Reagents: Water
1.3 Reagents: N-Bromosuccinimide ,  Triphenylphosphine Solvents: Tetrahydrofuran ;  45 min, 0 °C → rt
1.4 Reagents: Sodium thiosulfate

Reference

Base-promoted tandem synthesis of 2-azaaryl indoline

Chen, Shuguang; Tan, Jiahong; Wu, Hao; Zhao, Quansheng; Shang, Yongjia, Organic & Biomolecular Chemistry, 2023, 21(46), 9133-9137

Production Method 2

106308-60-5

85118-00-9

Reaction Conditions

1.1 Reagents: Sodium azide ;  60 min

Reference

A sequential multistep process for the fully mechanochemical, one-pot synthesis of the antiepileptic drug rufinamide

Gomez-Carpintero, Jorge; Cabrero, Clara; Sanchez, Juan Domingo; Gonzalez, Juan Francisco; Menendez, Jose Carlos, Green Chemistry Letters and Reviews, 2022, 15(3), 639-646

Production Method 3

19064-18-7

85118-00-9

Reaction Conditions

1.1 Reagents: Phosphorus tribromide Solvents: Dichloromethane ;  0 °C; 12 h, 0 °C
1.2 Reagents: Sodium bicarbonate

Reference

Mechanochemical Approach towards Multi-Functionalized 1,2,3-Triazoles and Anti-Seizure Drug Rufinamide Analogs Using Copper Beads

Bhattacherjee, Dhananjay; Kovalev, Igor S. ; Kopchuk, Dmitry S.; Rahman, Matiur; Santra, Sougata; et al, Molecules, 2022, 27(22),

Production Method 4

19064-18-7

85118-00-9

Reaction Conditions

1.1 Reagents: Phosphorus tribromide Solvents: Dichloromethane ;  0 °C; 12 h, 0 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  0 °C

Reference

Cu salts-free mechanochemical approach towards multi-functionalized 1,2,3-triazoles and anti-seizure drug Rufinamide analogs

Bhattacherjee, D.; Kovalev, I. S.; Kopchuk, D. S.; Rahman, M.; Santra, S.; et al, ChemRxiv, 2022, 1, 1-12

Production Method 5

443-84-5

85118-00-9

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Catalysts: Azobisisobutyronitrile Solvents: Ethyl acetate ;  3 h, reflux

Reference

Synthesis of rufinamide

Ju, Wenjian; Chen, Guohua; Hu, Yang; Zhang, Mingliang, Zhongguo Yiyao Gongye Zazhi, 2010, 41(4), 247-248

2,6-Difluorobenzyl bromide Raw materials

• 2,6-Difluorobenzaldehyde
• 2-(azidomethyl)-1,3-difluorobenzene
• 2,6-Difluorobenzyl alcohol
• 2,6-Difluorotoluene

2,6-Difluorobenzyl bromide Preparation Products

• 2,6-Difluorobenzyl bromide (85118-00-9)

• 1. An Assessment of the Laminar Hypersonic Double-Cone Experiments in the LENS-XX Tunnel
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• 3. An intramolecular tryptophan-condensation approach for peptide stapling?
  Eunice Y.-L. Hui,Bhimsen Rout,Yaw Sing Tan,Kok-Ping Chan,Charles W. Johannes Org. Biomol. Chem., 2018,16, 389-392
• 4. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzyl halides Benzyl bromides
• Solvents and Organic Chemicals Organic Compounds Organic Halides

• 157911-56-3(2,4,5-Trifluorobenzyl bromide)
• 23915-07-3(2,4-Difluorobenzyl bromide)
• 151412-12-3(2-Fluoro-3-methylbenzyl bromide)
• 157911-55-2(2,3,4-Trifluorobenzyl bromide)
• 118745-63-4(2-FLUORO-4-METHYLBENZYL BROMIDE)
• 151411-98-2(2,4,6-Trifluorobenzyl Bromide)
• 151412-02-1(2,3,6-Trifluorobenzyl Bromide)
• 446-48-0(1-(bromomethyl)-2-fluorobenzene)
• 85117-99-3(2,5-Difluorobenzyl bromide)
• 1765-40-8(2,3,4,5,6-Pentafluorobenzyl bromide)