Cas no 85-31-4 (6-Thioguanosine)

6-Thioguanosine structure
6-Thioguanosine structure
Product Name:6-Thioguanosine
CAS No:85-31-4
MF:C10H13N5O4S
MW:299.306319952011
MDL:MFCD00005736
CID:721895
PubChem ID:2724387
Update Time:2024-10-26

6-Thioguanosine Chemical and Physical Properties

Names and Identifiers

    • 6-Thioguanosine
    • 2-Amino-6-mercaptopurine-9-D-riboside Hydrate
    • 2-AMINO-6-MERCAPTOPURINE RIBOSIDE
    • 2-Amino-6-mercaptopurine-9-D-riboside
    • 6-Mercaptoguanine riboside
    • 6-MERCAPTOGUANOSINE
    • Guanosine, 6-thio-
    • 2-amino-6-mercaptopurine ribose
    • 6-thioguanineribose
    • 6-thio-guanosin
    • 6-thio-guanosine
    • ribosylthioguanine
    • sri759
    • TGR
    • thioguanineriboside
    • thioguanosine
    • 2-Amino-6-mercaptopurine ribonucleoside
    • 2-Amino-9-(beta-D-ribofuranosyl)purine-6-thiol
    • 6-Thioguanosine (ACI)
    • 6H-Purine-6-thione, 2-amino-1,9-dihydro-9-β-D-ribofuranosyl- (8CI)
    • 9H-Purine-6(1H)-thione, 2-amino-9-β-D-ribofuranosyl- (6CI, 7CI)
    • 2-Amino-9-(β-D-ribofuranosyl)purine-6-thiol
    • 2-Amino-9-β-D-ribofuranosyl-9H-purine-6-thiol
    • 2-Amino-9-β-D-ribofuranosylpurine-6-thione
    • 6-Thioguanine ribonucleoside
    • 6-Thioguanine riboside
    • 9-β-D-Ribofuranosylthioguanine
    • NSC-29422
    • SMR001233165
    • 6H-Purine-6-thione, 2-amino-1,9-dihydro-9-beta-D-ribofuranosyl-
    • Q27166529
    • 6H-Purine-6-thione, 2-amino-1,9-dihydro-9-.beta.-D-ribofuranosyl-
    • NCGC00179568-02
    • Prestwick0_000347
    • (2R,3R,4S,5R)-2-(2-amino-6-mercapto-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
    • 2-Amino-9-beta-D-ribofuranosyl-9H-purine-6-thiol
    • THIOGUANOSINE [MI]
    • BSPBio_000413
    • 85-31-4
    • TGS
    • 2-Amino-6-mercapto-9(beta-D-ribofuranosyl)purine
    • 2-Amino-6-mercapto-9-(b-D-ribofuranosyl)purine hydrate
    • 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]-3H-purine-6-thione
    • 2-Amino-9beta-D-ribofuranosyl-9H-purine-6-thiol
    • 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-3H-purine-6-thione
    • DTXCID501476984
    • 6-Thioguanosine?
    • Thioguanine riboside
    • 345909-25-3
    • AI3-50278
    • SCHEMBL230739
    • AKOS025401703
    • MFCD00005736
    • 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-6-purinethiolate
    • C558LI0K8P
    • 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purine-6-thione
    • cid_2724387
    • SK 18615
    • BRD-K75649340-002-02-2
    • CCG-220347
    • CHEMBL283078
    • (2R,3R,4S,5R)-2-(2-amino-6-sulfanyl-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
    • EINECS 201-597-2
    • AKOS015904198
    • Prestwick2_000347
    • CHEBI:94738
    • 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purine-6-thione
    • BRD-K75649340-001-13-1
    • NCGC00179568-01
    • 2-azanyl-9-[(2R,3R,4S,5R)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-3H-purine-6-thione
    • 2-Amino-6-mercaptopurin-9-ylriboside
    • 9-BETA-D-RIBOFURANOSYLTHIOGUANINE
    • 6-Thiodeoxyguanosine
    • Prestwick1_000347
    • Purine, 2-amino-6-mercapto-9-Beta-D-ribofuranosyl
    • Prestwick3_000347
    • 9H-Purine-6-thiol, 2-amino-9-beta-D-ribofuranosyl-
    • HMS3713E15
    • 6-Thioguanosine (VAN)
    • HMS2096E15
    • 9-.BETA.-D-RIBOFURANOSYLTHIOGUANINE
    • BDBM87350
    • MLS002153781
    • OTDJAMXESTUWLO-UUOKFMHZSA-N
    • SPBio_002334
    • UNII-C558LI0K8P
    • BS-17652
    • HMS2232C20
    • Guanosine, 6-thio-(9CI)
    • 9H-Purine-6-thiol, 2-amino-9beta-D-ribofuranosyl-
    • SRI 759
    • DTXSID201018977
    • AC-24682
    • BPBio1_000455
    • 6H-Purine-6-thione, 2-amino-1,9-dihydro-9-beta-D-ribofuranosyl-(8CI)
    • MDL： MFCD00005736
    • Inchi： 1S/C10H13N5O4S/c11-10-13-7-4(8(20)14-10)12-2-15(7)9-6(18)5(17)3(1-16)19-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,20)/t3-,5-,6-,9-/m1/s1
    • InChI Key： OTDJAMXESTUWLO-UUOKFMHZSA-N
    • SMILES： S=C1N=C(N)NC2N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C=NC1=2

Computed Properties

  • Exact Mass: 299.06900
  • Monoisotopic Mass: 299.06882509g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 6
  • Hydrogen Bond Acceptor Count: 9
  • Heavy Atom Count: 20
  • Rotatable Bond Count: 2
  • Complexity: 367
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 4
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: -1
  • Tautomer Count: 3
  • XLogP3: -0.6
  • Topological Polar Surface Area: 140

Experimental Properties

  • Color/Form: Uncertain.
  • Density: 2.18
  • Melting Point: 224-227 oC
  • Boiling Point: 756.9°C at 760 mmHg
  • Refractive Index: 1.6460 (estimate)
  • PSA: 174.53000
  • LogP: -0.73620
  • Solubility: Uncertain.

6-Thioguanosine Security Information

  • Safety Instruction： 24/25
  • RTECS：UP0200000

6-Thioguanosine Customs Data

  • HS CODE：2934999090
  • Customs Data：

    China Customs Code:

    2934999090

    Overview:

    2934999090. Other heterocyclic compounds. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

6-Thioguanosine Pricemore >>

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6-Thioguanosine Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Sodium methoxide Solvents: Methanol
Reference
Thiosulfate method of synthesizing 6-thioguanine and 6-thioguanosine
Calmane, L.; et al, Khimiko-Farmatsevticheskii Zhurnal, 1989, 23(9), 1129-31

Production Method 2

Reaction Conditions
Reference
Product class 17: purines
Seela, F.; et al, Science of Synthesis, 2004, 16, 945-1108

Production Method 3

Reaction Conditions
1.1 Reagents: Zinc chloride Solvents: Dimethylformamide
1.2 Reagents: Ethylenediaminetetraacetic acid ,  Sodium bicarbonate Solvents: Water
1.3 -
2.1 Reagents: Sodium perchlorate Solvents: Acetone ,  Water
Reference
Cap analogs containing 6-thioguanosine - reagents for the synthesis of mRNAs selectively photo-crosslinkable with cap-binding biomolecules
Nowakowska, Monika; et al, Organic & Biomolecular Chemistry, 2014, 12(27), 4841-4847

Production Method 4

Reaction Conditions
Reference
Product class 17: purines
Seela, F.; et al, Science of Synthesis, 2004, 16, 945-1108

Production Method 5

Reaction Conditions
Reference
Product class 17: purines
Seela, F.; et al, Science of Synthesis, 2004, 16, 945-1108

Production Method 6

Reaction Conditions
1.1 Solvents: Water ;  1 h, pH 7, 60 °C
Reference
Aeromonas hydrophila strains as biocatalysts for transglycosylation
Nobile, Matias; et al, Biocatalysis and Biotransformation, 2011, 28(5-6), 395-402

Production Method 7

Reaction Conditions
1.1 Solvents: Water ;  5 h, pH 7, 60 °C
Reference
Arthrobacter oxydans as a biocatalyst for purine deamination
Medici, Rosario; et al, FEMS Microbiology Letters, 2008, 289(1), 20-26

Production Method 8

Reaction Conditions
1.1 Reagents: Sodium thiosulfate Solvents: Ethanol
Reference
Sodium thiosulfate and potassium selenosulfate as reagents to prepare thio- and selenopurine nucleosides
Jankowski, Aleksander J.; et al, Nucleosides & Nucleotides, 1989, 8(3), 339-48

Production Method 9

Reaction Conditions
1.1 Reagents: Sodium thiosulfate Solvents: Water
2.1 Reagents: Sodium methoxide Solvents: Methanol
Reference
Thiosulfate method of synthesizing 6-thioguanine and 6-thioguanosine
Calmane, L.; et al, Khimiko-Farmatsevticheskii Zhurnal, 1989, 23(9), 1129-31

Production Method 10

Reaction Conditions
1.1 Reagents: Sodium thiosulfate Solvents: Ethanol ,  Water
Reference
Sodium thiosulfate and potassium selenosulfate as reagents to prepare thio- and selenopurine nucleosides
Jankowski, Aleksander J.; et al, Nucleosides & Nucleotides, 1989, 8(3), 339-48

Production Method 11

Reaction Conditions
1.1 Reagents: Pyridine ,  Trifluoroacetic anhydride Solvents: Pyridine
1.2 Reagents: Sodium hydrosulfide Solvents: Dimethylformamide
Reference
One-flask syntheses of 6-thioguanosine and 2'-deoxy-6-thioguanosine
Kung, Pei Pei; et al, Tetrahedron Letters, 1991, 32(32), 3919-22

Production Method 12

Reaction Conditions
1.1 Reagents: Sodium perchlorate Solvents: Acetone ,  Water
Reference
Cap analogs containing 6-thioguanosine - reagents for the synthesis of mRNAs selectively photo-crosslinkable with cap-binding biomolecules
Nowakowska, Monika; et al, Organic & Biomolecular Chemistry, 2014, 12(27), 4841-4847

Production Method 13

Reaction Conditions
Reference
Product class 17: purines
Seela, F.; et al, Science of Synthesis, 2004, 16, 945-1108

Production Method 14

Reaction Conditions
Reference
Product class 17: purines
Seela, F.; et al, Science of Synthesis, 2004, 16, 945-1108

Production Method 15

Reaction Conditions
Reference
Product class 17: purines
Seela, F.; et al, Science of Synthesis, 2004, 16, 945-1108

Production Method 16

Reaction Conditions
1.1 Reagents: Triethylamine ,  Triphenylphosphine ,  2,2′-Dipyridyl disulfide Solvents: Dimethylformamide ;  6 - 8 h, rt
1.2 Reagents: Lithium perchlorate Solvents: Acetone ;  rt
2.1 Reagents: Zinc chloride Solvents: Dimethylformamide
2.2 Reagents: Ethylenediaminetetraacetic acid ,  Sodium bicarbonate Solvents: Water
2.3 -
3.1 Reagents: Sodium perchlorate Solvents: Acetone ,  Water
Reference
Cap analogs containing 6-thioguanosine - reagents for the synthesis of mRNAs selectively photo-crosslinkable with cap-binding biomolecules
Nowakowska, Monika; et al, Organic & Biomolecular Chemistry, 2014, 12(27), 4841-4847

6-Thioguanosine Raw materials

6-Thioguanosine Preparation Products

6-Thioguanosine Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd
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(CAS:85-31-4)6-硫鳥嘌呤核苷
Order Number:LE1695637
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:34
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Amadis Chemical Company Limited
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(CAS:85-31-4)6-Thioguanosine
Order Number:A841290
Stock Status:in Stock
Quantity:1g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 06:53
Price ($):246.0
NewCan Biotech Limited
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(CAS:85-31-4)6-Thioguanosine
Order Number:NC14041
Stock Status:
Quantity:10g
Purity:97%
Pricing Information Last Updated:Friday, 18 July 2025 16:01
Price ($):Price inquiry

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Recommended suppliers
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:85-31-4)6-硫鳥嘌呤核苷
LE1695637
Purity:99%
Quantity:25KG,200KG,1000KG
Price ($):Inquiry
Email
Amadis Chemical Company Limited
(CAS:85-31-4)6-Thioguanosine
A841290
Purity:99%
Quantity:1g
Price ($):246.0
Email