Cas no 16321-99-6 (2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)purine)

2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine is a key intermediate in nucleoside synthesis, particularly for the preparation of modified purine derivatives. The compound features a protected ribofuranosyl moiety with acetyl groups at the 2', 3', and 5' positions, enhancing its stability during chemical transformations. The 2-amino-6-chloropurine base offers versatility for further functionalization, making it valuable in medicinal chemistry and oligonucleotide research. Its high purity and well-defined structure ensure reliable performance in coupling reactions and glycosylation processes. This intermediate is particularly useful in the synthesis of antiviral and anticancer nucleoside analogs, where precise control over stereochemistry and reactivity is critical.
2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)purine structure
16321-99-6 structure
Product Name:2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)purine
CAS No:16321-99-6
MF:C16H18ClN5O7
MW:427.796422481537
MDL:MFCD03425473
CID:208428
PubChem ID:125307287
Update Time:2025-11-05

2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)purine Chemical and Physical Properties

Names and Identifiers

    • (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2-amino-6-chloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate
    • 2',3',5'-Tri-O-acetyl-2-amino-6-chloropurine Riboside
    • 2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine
    • 6-CHLORO-6-DEOXY-2’,3’,5’-TRI-O-ACETYLGUANOSINE
    • 9H-Purin-2-amine,6-chloro-9-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)-
    • NULL
    • [(2R,3S,4S,5R)-3,4-diacetyloxy-5-(2-amino-6-chloropurin-9-yl)oxolan-2-yl]methyl acetate
    • ACETIC ACID (2R,3R,4R,5R)-3,4-DIACETOXY-5-(2-AMINO-6-CHLORO-PURIN-9-YL)-TETRAHYDRO-FURAN-2-YLMETHYL ESTER
    • 2-Amino-6-chloropurine ribonucleoside triacetate
    • 2',3',5'-Tri-O-acetyl-6-chloroguanosine
    • NSC 70388
    • 2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)purine
    • [(2R,3R,4R,5R)-3,4-bis(acetyloxy)-5-(2-amino-6-chloro-9H-purin-9-yl)oxolan-2-yl]methyl acetate
    • HLVGVJFVAKPFOZ-SDBHATRESA-N
    • C16H18ClN5O7
    • [(2r,3r,4r,5r)-3,4-diacetyloxy-5-(2-amino-6-chloropurin-9-yl)oxolan-2-yl]methyl acetate
    • 8292AA
    • 9-(2,3,5-tri- O-acetyl-beta-D-ribofuranosyl)-2-amino-6-chloro-9H-purine
    • F12905
    • AS-7059
    • 2-Chloro-6-amino-9-(2',3',5'-tri-O-acetyl- beta -D-ribofuranosyl)purine
    • 2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)purine
    • 2',3',5'-Tri-O-acetyl-6-chloro-6-deoxyguanosine
    • A810454
    • 16321-99-6
    • MFCD03425473
    • 9-(2',3',5'-Tri-O-acetyl-beta-D-ribofuranosyl)-2-amino-6-chloro-9H-purine
    • AKOS015967409
    • 9-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-2-amino-6-chloro-9H-purine
    • 2-Amino-6-chloropurine-9-(2 inverted exclamation mark ,3 inverted exclamation mark ,5 inverted exclamation mark -tri-O-acetyl)-riboside
    • 2-amino-9-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-6-chloro-9H-purine
    • (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2-amino-6-chloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyldiacetate
    • SCHEMBL1120550
    • T2690
    • 9-(2',3',5'-Tri-O-acetyl-beta-D-ribofuranosyl)-2-amino-6-chloro-(9H)-purine
    • 9H-Purin-2-amine, 6-chloro-9-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-
    • 2-amino-6-chloro-9-(2',3',5'-tri-O-acetyl-beta-D-ribofuranosyl) purine
    • 2-amino-6-chloro-9-(2',3',5'-tri-O-acetyl-beta-D-ribofuranosyl)purine
    • (2R,3R,4R,5R)-4-acetyloxy-5-(acetyloxymethyl)-2-(2-amino-6-chloropurin-9-yl)oxolan-3-yl acetate
    • 2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-?-D-ribofuranosyl)purine
    • DA-60011
    • [(2R,3R,4R,5R)-3,4-BIS(ACETYLOXY)-5-(2-AMINO-6-CHLOROPURIN-9-YL)OXOLAN-2-YL]METHYL ACETATE
    • MDL： MFCD03425473
    • Inchi： 1S/C16H18ClN5O7/c1-6(23)26-4-9-11(27-7(2)24)12(28-8(3)25)15(29-9)22-5-19-10-13(17)20-16(18)21-14(10)22/h5,9,11-12,15H,4H2,1-3H3,(H2,18,20,21)/t9-,11-,12-,15-/m1/s1
    • InChI Key： HLVGVJFVAKPFOZ-SDBHATRESA-N
    • SMILES： ClC1C2=C(N=C(N)N=1)N(C=N2)[C@H]1[C@@H]([C@@H]([C@@H](COC(C)=O)O1)OC(C)=O)OC(C)=O

Computed Properties

  • Exact Mass: 427.08900
  • Monoisotopic Mass: 427.089
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 11
  • Heavy Atom Count: 29
  • Rotatable Bond Count: 8
  • Complexity: 655
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 4
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 158
  • XLogP3: 0.2

Experimental Properties

  • Density: 1.70±0.1 g/cm3 (20 oC 760 Torr),
  • Melting Point: 146.0 to 150.0 deg-C
  • Boiling Point: 637°C at 760 mmHg
  • Flash Point: 339°C
  • Refractive Index: 1.69
  • Solubility: Almost insoluble (0.02 g/l) (25 o C),
  • PSA: 157.75000
  • LogP: 0.96700

2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)purine Security Information

  • Storage Condition：Sealed in dry,2-8°C

2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)purine Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd.
T855113-1g
2',3',5'-Tri-O-acetyl-2-amino-6-chloropurine Riboside
 16321-99-6 >97.0%(HPLC)(T)
1g
 949.50 2021-05-17
abcr
AB331864-1 g
2',3',5'-Tri-O-acetyl-2-amino-6-chloropurine riboside, 97%; .
 16321-99-6 97%
1 g
 €129.60 2023-07-19
SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd.
T63650-1g
(2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2-amino-6-chloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate
 16321-99-6 97%
1g
 ￥1208.0 2024-07-18
SHANG HAI YI EN HUA XUE JI SHU Co., Ltd.
R023433-1g
2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)purine
 16321-99-6 97%
1g
 ￥261 2024-05-25
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
A132789-1g
2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)purine
 16321-99-6 ≥97.0%(HPLC)
1g
 ￥1087.90 2023-09-04
Alichem
A159002725-1g
(2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2-amino-6-chloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate
 16321-99-6 95%
1g
 182.16 USD 2021-06-11
Alichem
A159002725-5g
(2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2-amino-6-chloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate
 16321-99-6 95%
5g
 638.55 USD 2021-06-11
TRC
A603515-500mg
2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)purine
 16321-99-6
500mg
 $ 121.00 2023-09-08
TRC
A603515-1g
2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)purine
 16321-99-6
1g
 $ 224.00 2023-09-08
TRC
A603515-5g
2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)purine
 16321-99-6
5g
 $ 580.00 2023-09-08

2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)purine Production Method

2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)purine Suppliers

NewCan Biotech Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:16321-99-6)2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside
Order Number:NC8277
Stock Status:
Quantity:10g
Purity:97%
Pricing Information Last Updated:Friday, 18 July 2025 16:12
Price ($):Price inquiry

2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)purine Related Literature

Additional information on 2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)purine

Market Research and Analysis Report on 2-Amino-6-Chloro-9-(2,3,5-Tri-O-Acetyl-b-D-Ribofuranosyl)Purine (CAS No. 16321-99-6)

Recent advancements in the field of chemical biology and pharmaceutical research have brought significant attention to the compound 2-Amino-6-Chloro-9-(2,3,5-Tri-O-Acetyl-b-D-Ribofuranosyl)Purine, identified by the CAS number 16321-99-6. This compound has emerged as a critical molecule in nucleoside analog development, particularly in the context of antiviral and anticancer therapies.

The growing demand for innovative therapeutic agents has driven extensive research into the synthesis, characterization, and biological evaluation of this compound. Its unique structural features make it a promising candidate for targeting specific viral enzymes and cellular pathways associated with oncogenesis.

Market analysis indicates a rising interest in suppliers capable of providing high-purity samples of 2-Amino-6-Chloro-9-(2,3,5-Tri-O-Acetyl-b-D-Ribofuranosyl)Purine. This demand is fueled by ongoing clinical trials and preclinical studies aimed at assessing its efficacy and safety profiles.

Research methodologies employed to evaluate this compound include X-ray crystallography for structural elucidation, enzymatic assays to determine inhibitory activity, and in vivo studies to assess pharmacokinetics and toxicity. These studies have provided valuable insights into its potential applications in drug development.

Results from recent studies highlight the compound's potent antiviral activity against RNA viruses, such as hepatitis C virus (HCV), and its selective cytotoxicity against cancer cell lines. These findings underscore its potential as a lead compound for developing next-generation antiviral and anticancer therapeutics.

In conclusion, the compound 2-Amino-6-Chloro-9-(2,3,5-Tri-O-Acetyl-b-D-Ribofuranosyl)Purine (CAS No. 16321-99-6) represents a promising avenue for advancing chemical biology research and pharmaceutical development. Its continued exploration is expected to yield significant contributions to the field of nucleoside analog-based therapies.

16321-99-6 (2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)purine) Related Products

Recommended suppliers
NewCan Biotech Limited
(CAS:16321-99-6)2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside
NC8277
Purity:97%
Quantity:10g
Price ($):Inquiry
Email