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• 2. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
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• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Purine nucleosides Purine nucleosides
• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Purine nucleosides
• Solvents and Organic Chemicals Organic Compounds Acids/Esters
• Other Chemical Reagents

Introduction to 2-Amino-6-chloropurine-9-β-D-riboside (CAS No. 2004-07-1)

2-Amino-6-chloropurine-9-β-D-riboside, with the chemical identifier CAS No. 2004-07-1, is a significant compound in the field of nucleoside chemistry and pharmaceutical research. This nucleoside analog plays a crucial role in the development of novel therapeutic agents, particularly in the treatment of various diseases such as cancer, viral infections, and genetic disorders. The compound's unique structural properties, derived from its purine core and ribose sugar moiety, make it a valuable intermediate in synthetic biology and drug design.

The molecular structure of 2-Amino-6-chloropurine-9-β-D-riboside consists of a purine base substituted with an amino group at the 2-position and a chlorine atom at the 6-position, linked to a β-D-ribose sugar. This configuration imparts distinct biochemical and pharmacological characteristics that have been extensively studied in recent years. The presence of the amino group enhances the compound's reactivity, making it a versatile scaffold for further derivatization, while the chlorine atom at the 6-position influences its binding affinity to biological targets.

In recent years, significant advancements have been made in understanding the therapeutic potential of 2-Amino-6-chloropurine-9-β-D-riboside. Research has demonstrated its efficacy in inhibiting specific enzymes and pathways involved in disease progression. For instance, studies have shown that this compound exhibits potent antiviral activity against certain RNA viruses by interfering with viral replication mechanisms. The mechanism of action involves competitive inhibition of viral polymerases, thereby disrupting the synthesis of viral genetic material.

Moreover, 2-Amino-6-chloropurine-9-β-D-riboside has shown promise in oncology research. Preclinical studies indicate that it can selectively target rapidly dividing cancer cells by inducing DNA damage or inhibiting key signaling pathways. The compound's ability to mimic natural nucleosides allows it to be incorporated into DNA and RNA, leading to structural alterations that impair cellular function. These findings have prompted further investigation into its potential as a chemotherapeutic agent, particularly in combination regimens with other anticancer drugs.

The synthesis of 2-Amino-6-chloropurine-9-β-D-riboside is a complex process that requires precise chemical manipulation to achieve high yields and purity. Researchers have developed multiple synthetic routes, leveraging enzymatic and chemical transformations to construct the desired structure efficiently. Advances in biocatalysis have enabled the use of engineered enzymes to facilitate key steps in the synthesis, reducing reliance on harsh chemical conditions and improving overall sustainability.

Recent studies have also explored the pharmacokinetic properties of 2-Amino-6-chloropurine-9-β-D-riboside, aiming to optimize its delivery and bioavailability. Investigations into prodrugs and delivery systems have shown that modifications to the ribose moiety can enhance cellular uptake and reduce metabolic degradation. These developments are critical for translating preclinical successes into effective clinical therapies.

The regulatory landscape for 2-Amino-6-chloropurine-9-β-D-riboside is evolving alongside advancements in drug development methodologies. Regulatory agencies are increasingly recognizing the importance of nucleoside analogs in therapeutic innovation and are streamlining pathways for their approval. This trend bodes well for future clinical trials and commercialization efforts involving this compound.

In conclusion, 2-Amino-6-chloropurine-9-β-D-riboside (CAS No. 2004-07-1) represents a compelling area of research with broad therapeutic implications. Its unique structural features, combined with emerging insights into its biological activity, position it as a key candidate for further development in pharmaceutical applications. As research continues to uncover new mechanisms and applications, this compound is poised to play an increasingly significant role in addressing unmet medical needs.

• 5399-87-1((2R,3R,4S,5R)-2-(6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol)
• 415705-32-7((2S,3S,4R,5S)-2-(6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol)
• 122970-35-8(2-Furanmethanol,5-(2-amino-6-chloro-9H-purin-9-yl)tetrahydro-, (2S,5R)-)
• 13276-52-3((2R,3R,4S,5R)-2-(2,6-dichloro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol)
• 34793-10-7(2-Amino-6-chloropurine riboside)
• 112506-90-8(9H-Purine,6-chloro-9-(5-deoxy-b-D-ribofuranosyl)-)
• 2004-06-0(6-Chloropurine riboside)
• 120595-72-4(2-Amino-6-chloro-9-(2'-deoxy-b-D-ribofuranosyl)purine)
• 15645-47-3(9H-Purin-2-amine,6,8-dichloro-9-b-D-ribofuranosyl-)
• 16321-99-6(2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)purine)