Cas no 84793-07-7 (N-(9-Fluorenylmethoxycarbonyl)glutamic acid α-tert-butyl ester)

N-(9-Fluorenylmethoxycarbonyl)glutamic acid α-tert-butyl ester structure
84793-07-7 structure
Product Name:N-(9-Fluorenylmethoxycarbonyl)glutamic acid α-tert-butyl ester
CAS No:84793-07-7
MF:C24H27NO6
MW:425.4742872715
MDL:MFCD00065648
CID:60768
PubChem ID:7017912
Update Time:2024-10-26

N-(9-Fluorenylmethoxycarbonyl)glutamic acid α-tert-butyl ester Chemical and Physical Properties

Names and Identifiers

    • Fmoc-L-Glutamic acid 1-tert-butyl ester
    • N-(9-Fluorenylmethoxycarbonyl)glutamic acid α-tert-butyl ester
    • (4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid
    • FMOC-GLU-OBUT
    • Fmoc-Glu-OtBu
    • Fmoc-L-Glu-OtBu
    • Fmoc-L-glutamic acid α-tert.butyl ester
    • N-Fmoc-L-glutamic acid 1-tert-butyl ester
    • Fmoc-L-Glu-O-t-Bu
    • Fmoc-Glu-O-t-Bu
    • Fmoc-Glu(OBut)-OH
    • (S)-4-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-tert-butoxy-5-oxopentanoic acid
    • Fmoc-Glu-Ot-Bu
    • PubChem10014
    • KSC448A0B
    • GOPWHXPXSPIIQZ-FQEVSTJZSA-N
    • BCP26020
    • C
    • (4S)-5-(tert-Butoxy)-4-([[(9H-fluoren-9-yl)methoxy]carbonyl]amino)-5-oxopentanoic acid
    • 10: PN: CN1962691 PAGE: 3 claimed protein
    • MDL： MFCD00065648
    • Inchi： 1S/C24H27NO6/c1-24(2,3)31-22(28)20(12-13-21(26)27)25-23(29)30-14-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,19-20H,12-14H2,1-3H3,(H,25,29)(H,26,27)/t20-/m0/s1
    • InChI Key： GOPWHXPXSPIIQZ-FQEVSTJZSA-N
    • SMILES： C(C1C2C=CC=CC=2C2C=CC=CC1=2)OC(=O)N[C@@H](CCC(=O)O)C(=O)OC(C)(C)C

Computed Properties

  • Exact Mass: 425.18400
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 6
  • Heavy Atom Count: 31
  • Rotatable Bond Count: 10
  • Complexity: 635
  • Topological Polar Surface Area: 102

Experimental Properties

  • Melting Point: 105-113°C
  • Boiling Point: 638.1℃ at 760 mmHg
  • Refractive Index: 1.57
  • PSA: 101.93000
  • LogP: 4.49110
  • Specific Rotation: -8.0° - -12.0° (c=1, CH3COOH)

N-(9-Fluorenylmethoxycarbonyl)glutamic acid α-tert-butyl ester Security Information

N-(9-Fluorenylmethoxycarbonyl)glutamic acid α-tert-butyl ester Customs Data

  • HS CODE：29224290

N-(9-Fluorenylmethoxycarbonyl)glutamic acid α-tert-butyl ester Pricemore >>

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TRC
F620165-100mg
Fmoc-Glu-OtBu
 84793-07-7
100mg
 $64.00 2023-05-18
TRC
F620165-250mg
Fmoc-Glu-OtBu
 84793-07-7
250mg
 $75.00 2023-05-18
TRC
F620165-500mg
Fmoc-Glu-OtBu
 84793-07-7
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 $87.00 2023-05-18
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Fmoc-Glu-OtBu
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N-(9-Fluorenylmethoxycarbonyl)glutamic acid α-tert-butyl ester Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Sodium carbonate Solvents: 1,4-Dioxane ,  Water
Reference
Folate analogs. 33. Synthesis of folate and antifolate poly-γ-glutamates by [(9-fluorenylmethoxy)oxy]carbonyl chemistry and biological evaluation of certain methotrexate polyglutamate polylysine conjugates as inhibitors of the growth of H35 hepatoma cells
Abraham, Ann; Nair, M. G.; Kisliuk, R. L.; Galivan, J.; Gaumont, Y., Journal of Medicinal Chemistry, 1990, 33(2), 711-17

Production Method 2

Reaction Conditions
Reference
A simple and convenient synthesis of ω-tert-butyl esters of Fmoc-aspartic and Fmoc-glutamic acids
Lajoie, Gilles; Crivici, Anna; Adamson, J. Gordon, Synthesis, 1990, (7), 571-2

Production Method 3

Reaction Conditions
1.1 Reagents: Diisopropylethylamine ,  2-Chlorotrityl chloride resin Solvents: Dichloromethane ;  60 min, rt
1.2 Reagents: Diisopropylethylamine Solvents: Methanol ;  15 min, rt
Reference
Improved folate extraction and tracing deconjugation efficiency by dual label isotope dilution assays in foods
Moench, Sabine; Rychlik, Michael, Journal of Agricultural and Food Chemistry, 2012, 60(6), 1363-1372

N-(9-Fluorenylmethoxycarbonyl)glutamic acid α-tert-butyl ester Raw materials

N-(9-Fluorenylmethoxycarbonyl)glutamic acid α-tert-butyl ester Preparation Products

N-(9-Fluorenylmethoxycarbonyl)glutamic acid α-tert-butyl ester Suppliers

Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:84793-07-7)Fmoc-L-Glutamic acid 1-tert-butyl ester
Order Number:sfd1307
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:32
Price ($):discuss personally

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Suzhou Senfeida Chemical Co., Ltd
(CAS:84793-07-7)Fmoc-L-Glutamic acid 1-tert-butyl ester
sfd1307
Purity:99.9%
Quantity:200kg
Price ($):Inquiry
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