Production Method 1

463-52-5

609-15-4

83942-10-3

Reaction Conditions

1.1 Reagents: Sodium methoxide Solvents: Methanol ;  -5 °C; 1 h, -5 °C; -5 °C → rt; 24 h, rt; 0.5 h, reflux; reflux → rt
1.2 Reagents: Acetic acid ;  rt
2.1 Reagents: Phosphorus oxychloride ;  3 h, rt → reflux

Reference

Synthesis and bioactivity of diflumetorim

Yang, Fan; et al, Nongyao, 2013, 52(12), 868-870

Production Method 2

3524-87-6

83942-10-3

Reaction Conditions

1.1 Reagents: Hydrochloric acid ,  Hydrogen peroxide
1.2 Reagents: Phosphorus oxychloride

Reference

Studies on pyrimidine derivatives. XXXIX. Site-selectivity in the reaction of 5-substituted and 4,5-disubstituted pyrimidine N-oxides with trimethylsilyl cyanide

Yamanaka, Hiroshi; et al, Chemical & Pharmaceutical Bulletin, 1987, 35(8), 3119-26

Production Method 3

141-97-9

83942-10-3

Reaction Conditions

1.1 Reagents: Sulfuryl chloride Solvents: Dichloromethane ;  -5 - 0 °C; 10 h, -5 - 0 °C
2.1 Reagents: Sodium methoxide Solvents: Methanol ;  30 min, rt
2.2 -5 - 0 °C; 3 h, 0 °C → reflux
3.1 Reagents: Triethylamine ,  Phosphorus oxychloride Solvents: Toluene ;  12 h, -5 - 0 °C
3.2 Solvents: Water ;  0 °C
3.3 Reagents: Potassium carbonate ;  basified

Reference

Design, synthesis, insecticidal, and acaricidal activities of novel pyrimidinamine derivatives containing a biphenyl ether

Li, Lizhong ; et al, Journal of Heterocyclic Chemistry, 2019, 56(12), 3206-3214

Production Method 4

141-97-9

83942-10-3

Reaction Conditions

1.1 Reagents: Thionyl chloride Solvents: Carbon tetrachloride ;  0 °C; overnight, rt
2.1 Reagents: Sodium methoxide Solvents: Methanol ;  -5 °C; 1 h, -5 °C; -5 °C → rt; 24 h, rt; 0.5 h, reflux; reflux → rt
2.2 Reagents: Acetic acid ;  rt
3.1 Reagents: Phosphorus oxychloride ;  3 h, rt → reflux

Reference

Synthesis and bioactivity of diflumetorim

Yang, Fan; et al, Nongyao, 2013, 52(12), 868-870

4,5-Dichloro-6-methylpyrimidine Raw materials

• Ethyl acetoacetate
• 6-methyl-1,4-dihydropyrimidin-4-one
• methanimidamide
• Ethyl 2-chloroacetoacetate

4,5-Dichloro-6-methylpyrimidine Preparation Products

• 4,5-Dichloro-6-methylpyrimidine (83942-10-3)

• 1. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 2. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
• 3. Estimates of hydride ion stability in condensed systems: energy of formation and solvation in aqueous and polar-organic solvents
  Craig A. Kelly,David R. Rosseinsky Phys. Chem. Chem. Phys., 2001,3, 2086-2090
• 4. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110
• 5. Exclusive self-aligned β-phase PVDF films with abnormal piezoelectric coefficient prepared via phase inversion?
  N. Soin,D. Boyer,K. Prashanthi,S. Sharma,A. A. Narasimulu,J. Luo,T. H. Shah,E. Siores,T. Thundat Chem. Commun., 2015,51, 8257-8260

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Halopyrimidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Halopyrimidines

• 141602-30-4(4,5-Dichloro-6-isopropylpyrimidine)
• 7749-60-2(4,5-Dichloro-6-methylpyrimidin-2-amine)
• 115617-41-9(4,5-Dichloro-6-ethylpyrimidine)
• 105742-66-3(4,5-Dichloro-2,6-dimethylpyrimidine)
• 141602-36-0(4,5-Dichloro-6-(trifluoromethyl)pyrimidine)
• 425394-19-0(4,5-dichloro-6-(difluoromethyl)pyrimidine)
• 3435-25-4(4-Chloro-6-methylpyrimidine)
• 105708-06-3(Pyrimidine, 4,5-dichloro-6-(chloromethyl)-)
• 6585-48-4(2,4,5-trichloro-6-ethylpyrimidine)
• 6554-69-4(2,4,5-Trichloro-6-methylpyrimidine)