Production Method 1

79265-30-8

83553-48-4

81449-93-6

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Diethyl ether ,  Hexane ;  30 min, -78 °C
1.2 30 min, -78 °C; 30 min, rt; rt → -78 °C
1.3 Reagents: Iodine Solvents: Tetrahydrofuran ;  -78 °C → rt; 15 h, rt; rt → -78 °C
1.4 Reagents: Sodium thiosulfate Solvents: Water

Reference

Tandem photoarylation-photoisomerization of halothiazoles: synthesis, photophysical and singlet oxygen activation properties of ethyl 2-arylthiazole-5-carboxylates

Amati, Mario; et al, European Journal of Organic Chemistry, 2010, (18), 3416-3427

5-Thiazolecarboxylic acid, 2-iodo-, ethyl ester Raw materials

• 2-(trimethylsilyl)-1,3-thiazole

5-Thiazolecarboxylic acid, 2-iodo-, ethyl ester Preparation Products

• 5-Thiazolecarboxylic acid, 2-iodo-, ethyl ester (83553-48-4)
• Ethyl 2-chlorothiazole-5-carboxylate (81449-93-6)

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