Production Method 1

75-77-4

3034-53-5

79265-30-8

Reaction Conditions

1.1 Reagents: Butyllithium ;  -78 °C
1.2 Solvents: Diethyl ether

Reference

n-Type Organic Field-Effect Transistors with High Electron Mobilities Based on Thiazole-Thiazolothiazole Conjugated Molecules

Mamada, Masashi; Nishida, Jun-Ichi; Kumaki, Daisuke; Tokito, Shizuo; Yamashita, Yoshiro, Chemistry of Materials, 2007, 19(22), 5404-5409

Production Method 2

75-77-4

3034-53-5

79265-30-8

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Diethyl ether ,  Hexane ;  -78 °C; 15 min, -78 °C; 1 h, -78 °C
1.2 1 h, -78 °C; 1 h, -78 °C
1.3 Reagents: Potassium carbonate Solvents: Water ;  0 °C

Reference

Discovery of the Orally Effective Thyrotropin-Releasing Hormone Mimetic: 1-{N-[(4S,5S)-(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-3-(thiazol-4-yl)-L-alanyl}-(2R)-2-methylpyrrolidine Trihydrate (Rovatirelin Hydrate)

Kobayashi, Naotake ; Sato, Norihito; Fujimura, Yuko; Kihara, Tsuyoshi; Sugita, Katsuji; et al, ACS Omega, 2018, 3(10), 13647-13666

Production Method 3

75-77-4

3034-53-5

79265-30-8

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Diethyl ether
1.2 -

Reference

Diastereoselective homologation of D-(R)-glyceraldehyde acetonide using 2-(trimethylsilyl)thiazole: 2-O-benzyl-3,4-isopropylidene-D-erythrose (1,3-dioxolane-4-acetaldehyde, 2,2-dimethyl-α-(phenylmethoxy)-, [R-(R*,R*)]-)

Dondoni, Alessandro; Merino, Pedro, Organic Syntheses, 1995, 72, 21-31

Production Method 4

75-77-4

288-47-1

79265-30-8

Reaction Conditions

Reference

Product class 17: thiazoles

Kikelj, D.; Urleb, U., Science of Synthesis, 2002, 11, 627-833

Production Method 5

75-77-4

3034-53-5

79265-30-8

Reaction Conditions

1.1 Catalysts: Butyllithium

Reference

Reactions of trimethylsilylthiazoles with ketens: a new route to regioselective functionalization of the thiazole ring

Medici, Alessandro; Pedrini, Paola; Dondoni, Alessandro, Journal of the Chemical Society, 1981, (13), 655-6

Production Method 6

75-77-4

3034-53-5

79265-30-8

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Diethyl ether ;  -78 °C

Reference

Synthesis of 5-arylthiazoles. Comparative study between Suzuki cross-coupling reaction and direct arylation

Primas, Nicolas; Bouillon, Alexandre; Lancelot, Jean-Charles; El-Kashef, Hussein; Rault, Sylvain, Tetrahedron, 2009, 65(29-30), 5739-5746

Production Method 7

75-77-4

3034-53-5

79265-30-8

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Diethyl ether
1.2 -

Reference

Synthesis of (trimethylsilyl)thiazoles and reactions with carbonyl compounds. Selectivity aspects and synthetic utility

Dondoni, Alessandro; Fantin, Giancarlo; Fogagnolo, Marco; Medici, Alessandro; Pedrini, Paola, Journal of Organic Chemistry, 1988, 53(8), 1748-61

Production Method 8

75-77-4

288-47-1

79265-30-8

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ;  10 min, -78 °C; 1 h, -78 °C
1.2 Solvents: Tetrahydrofuran ;  -78 °C; 1 h, -78 °C
1.3 Reagents: Sodium bicarbonate Solvents: Water ;  -78 °C

Reference

Efficient access to 5-substituted thiazoles by a novel metallotropic rearrangement

Zambon, Alfonso; Borsato, Giuseppe; Brussolo, Stefania; Frascella, Pietrogiulio; Lucchini, Vittorio, Tetrahedron Letters, 2008, 49(1), 66-69

Production Method 9

75-77-4

3034-53-5

79265-30-8

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Diethyl ether ;  30 min, -78 °C; 30 min, -78 °C
1.2 Solvents: Diethyl ether ;  -78 °C; 1 h, -78 °C; -78 °C → rt
1.3 Reagents: Sodium bicarbonate Solvents: Water ;  rt

Reference

Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitors

Schmitt, Christian; Kail, Dagmar; Mariano, Marica; Empting, Martin; Weber, Nadja; et al, PLoS One, 2014, 9(3),

Production Method 10

75-77-4

3034-53-5

79265-30-8

Reaction Conditions

1.1 Catalysts: Butyllithium

Reference

2-(Trimethylsilyl)thiazole

Dondoni, Alessandro; Merino, Pedro, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001, ,

2-(trimethylsilyl)-1,3-thiazole Raw materials

• Chlorotrimethylsilane
• Thiazole
• 2-Bromothiazole

2-(trimethylsilyl)-1,3-thiazole Preparation Products

• 2-(trimethylsilyl)-1,3-thiazole (79265-30-8)

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• Solvents and Organic Chemicals Organic Compounds Organometallic compounds Organometalloid compounds Organosilicon compounds Alkylarylsilanes

• 533887-53-5(5-Bromo-2-(trimethylsilyl)thiazole)
• 167405-22-3(Thiazole, 4-methyl-2-(trimethylsilyl)-)
• 108306-53-2((4-bromothiazol-2-yl)-trimethyl-silane)
• 137382-38-8(2-(tert-Butyldimethylsilyl)thiazole)
• 681218-90-6(3,6,7-Benzofurantriol triacetate)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)