Production Method 1

79265-30-8

81449-93-6

83553-48-4

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Diethyl ether ,  Hexane ;  30 min, -78 °C
1.2 30 min, -78 °C; 30 min, rt; rt → -78 °C
1.3 Reagents: Iodine Solvents: Tetrahydrofuran ;  -78 °C → rt; 15 h, rt; rt → -78 °C
1.4 Reagents: Sodium thiosulfate Solvents: Water

Reference

Tandem photoarylation-photoisomerization of halothiazoles: synthesis, photophysical and singlet oxygen activation properties of ethyl 2-arylthiazole-5-carboxylates

Amati, Mario; et al, European Journal of Organic Chemistry, 2010, (18), 3416-3427

Ethyl 2-chlorothiazole-5-carboxylate Raw materials

• 2-(trimethylsilyl)-1,3-thiazole

Ethyl 2-chlorothiazole-5-carboxylate Preparation Products

• 5-Thiazolecarboxylic acid, 2-iodo-, ethyl ester (83553-48-4)
• Ethyl 2-chlorothiazole-5-carboxylate (81449-93-6)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Thiazolecarboxylic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Thiazoles Thiazolecarboxylic acids and derivatives

• 32955-22-9(ethyl 1,3-thiazole-5-carboxylate)
• 1209494-04-1(2-CHLORO-5-ETHOXYMETHYL-THIAZOLE)
• 339018-65-4((2-CHLORO-1,3-THIAZOL-5-YL)METHYLACETATE)
• 125759-82-2(5-Thiazolecarboxylicacid, 2,4-dichloro-, ethyl ester)
• 101012-12-8(2-Chloro-1,3-thiazole-5-carboxylic Acid)
• 7238-62-2(Ethyl 2-Chloro-4-methylthiazole-5-carboxylate)
• 14527-44-7(Methyl thiazole-5-carboxylate)
• 72605-86-8(methyl 2-chloro-1,3-thiazole-5-carboxylate)
• 340294-07-7(2-chloro-5-(methoxymethyl)-1,3-thiazole)
• 934570-60-2(tert-butyl 2-chloro-1,3-thiazole-5-carboxylate)