Production Method 1

82911-69-1

2788-84-3

82911-78-2

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: 1,4-Dioxane ,  Water ;  30 min, 0 °C; overnight, 0 °C

Reference

C-Glycosyl Amino Acids through Hydroboration-Cross-Coupling of exo-Glycals and Their Application in Automated Solid-Phase Synthesis

Koch, Stefan; et al, Chemistry - A European Journal, 2013, 19(22), 7020-7041

Production Method 2

82911-69-1

5680-80-8

82911-78-2

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: 1,4-Dioxane ,  Water ;  5 h, 25 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  25 °C

Reference

Solution-phase automated synthesis of an α-amino aldehyde as a versatile intermediate

Masui, Hisashi; et al, Beilstein Journal of Organic Chemistry, 2017, 13, 106-110

Production Method 3

171820-89-6

82911-78-2

Reaction Conditions

1.1 Catalysts: 2,4,6-Triphenylpyrylium tetrafluoroborate Solvents: Dichloromethane ;  5 min, rt; 2 h, rt

Reference

Photocatalytic Cleavage of Trityl Protected Thiols and Alcohols

Murakami, Sho; et al, Synthesis, 2023, 55(9), 1367-1374

Production Method 4

73724-45-5

82911-78-2

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  30 min, rt; rt → 0 °C
1.2 0 °C

Reference

Synthesis and Applications of a Light-Fluorous Glycosyl Donor

Zhang, Fa; et al, Journal of Organic Chemistry, 2009, 74(6), 2594-2597

Production Method 5

73724-45-5

82911-78-2

Reaction Conditions

1.1 Solvents: Diethyl ether ;  30 min, rt
1.2 Solvents: Water ;  rt

Reference

Synthesis of chlorophyll-amino acid conjugates as models for modification of proteins with chromo/fluorophores

Tamiaki, Hitoshi; et al, Bioorganic & Medicinal Chemistry, 2014, 22(4), 1421-1428

Production Method 6

82911-71-5

2788-84-3

82911-78-2

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: Acetone

Reference

9-Fluorenylmethyl 1-benzotriazolyl carbonate(3-oxy-benzotriazolinium-1-carboxylic acid 9H-fluoren-9-ylmethyl ester)

Wardrop, Duncan J.; et al, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2003, 1, 1-2

Production Method 7

24184-43-8

28920-43-6

82911-78-2

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: Ethyl acetate ,  Water ;  45 min, 0 °C

Reference

A modified fluoro-Pummerer reaction with DAST and NIS for synthesis of β-amino-α-fluoro-sulfides from corresponding β-amino-sulfides

Chen, Hongju; et al, Tetrahedron, 2015, 71(14), 2089-2094

Production Method 8

2454471-89-5

82911-78-2

Reaction Conditions

1.1 Reagents: Borate(1-), trifluoro(4-methylphenyl)-, potassium (1:1), (T-4)- Solvents: Dimethyl sulfoxide ;  24 h, 37 °C

Reference

Exploration of the Fluoride Reactivity of Aryltrifluoroborate on Selective Cleavage of Diphenylmethylsilyl Groups

Fujiki, Katsumasa; et al, European Journal of Organic Chemistry, 2020, 2020(29), 4616-4620

Production Method 9

82911-78-2

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Methanol ,  Ethyl acetate ;  5 min, 50 °C; cooled
1.2 Reagents: Sodium bicarbonate ;  neutralized

Reference

A Rapid and Mild Sulfation Strategy Reveals Conformational Preferences in Therapeutically Relevant Sulfated Xylooligosaccharides

Vo, Yen; et al, Chemistry - A European Journal, 2021, 27(38), 9830-9838

Production Method 10

82911-69-1

2788-84-3

82911-78-2

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: Tetrahydrofuran ,  Water ;  1 h, 0 °C; 0 °C → 18 °C; 18 h, 18 °C

Reference

A Rapid and Mild Sulfation Strategy Reveals Conformational Preferences in Therapeutically Relevant Sulfated Xylooligosaccharides

Vo, Yen; et al, Chemistry - A European Journal, 2021, 27(38), 9830-9838

Production Method 11

82911-78-2

Reaction Conditions

1.1 Catalysts: Zincate(1-), μ4-oxohexakis[μ-(2,2,2-trifluoroacetato-κO:κO′)](2,2,2-trifluoroace… Solvents: Methanol ;  12 h, 70 °C

Reference

Tetranuclear zinc cluster: a dual purpose catalyst for per-O-acetylation and de-O-acetylation of carbohydrates

Lin, Ting-Wei; et al, RSC Advances, 2016, 6(63), 58749-58754

Production Method 12

82911-78-2

Reaction Conditions

1.1 Catalysts: Zincate(1-), μ4-oxohexakis[μ-(2,2,2-trifluoroacetato-κO:κO′)](2,2,2-trifluoroace… Solvents: Methanol ;  12 h, 70 °C

Reference

Tetranuclear zinc cluster: a dual purpose catalyst for per-O-acetylation and de-O-acetylation of carbohydrates

Lin, Ting-Wei; et al, RSC Advances, 2016, 6(63), 58749-58754

Production Method 13

73724-45-5

82911-78-2

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  > 1 min, 0 °C
1.2 0 °C; 4 h, 0 °C

Reference

Sterically Hindered 2,4,6-Tri-tert-butylpyridinium Salts as Single Hydrogen Bond Donors for Highly Stereoselective Glycosylation Reactions of Glycals

Ghosh, Titli; et al, Organic Letters, 2019, 21(10), 3490-3495

Production Method 14

73724-45-5

82911-78-2

Reaction Conditions

1.1 Reagents: Thionyl chloride Solvents: Methanol

Reference

Design, Syntheses, and Bioactivities of Conformationally Locked Pin1 Ground State Inhibitors

Wang, Xiaodong J., 2005, , ,

Production Method 15

73724-45-5

82911-78-2

Reaction Conditions

1.1 Reagents: Dowex 50WX2 ;  overnight, reflux

Reference

L-serine-functionalized montmorillonite decorated with Au nanoparticles: A new highly efficient catalyst for the reduction of 4-nitrophenol

Rocha, Mariana; et al, Journal of Catalysis, 2018, 361, 143-155

Production Method 16

82911-69-1

5680-80-8

82911-78-2

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: 1,4-Dioxane ,  Water ;  30 min, rt
1.2 rt; 24 h, rt

Reference

Coupled Conformational Equilibria in β-Sheet Peptide-Dendron Conjugates

Shao, Hui; et al, Journal of the American Chemical Society, 2007, 129(7), 1884-1885

Production Method 17

82911-69-1

5680-80-8

82911-78-2

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: Tetrahydrofuran ,  Water ;  rt

Reference

Total synthesis and structure revision of boholamide A

Han, Fangzhi; et al, Organic Letters, 2021, 23(13), 4976-4980

Production Method 18

171820-89-6

82911-78-2

Reaction Conditions

1.1 Catalysts: Indium triflate ;  15 min, rt

Reference

In(III) triflate-catalyzed detritylation and glycosylation by solvent-free ball milling

Kumar, Vajinder; et al, Carbohydrate Research, 2014, 397, 18-26

Production Method 19

82911-78-2

Reaction Conditions

1.1 Reagents: Sodium azide Solvents: Methanol

Reference

Mild and selective sodium azide mediated cleavage of p-nitrobenzoic esters

Gomez-Vidal, Jose A.; et al, Organic Letters, 2001, 3(16), 2477-2479

Production Method 20

82911-78-2

Reaction Conditions

1.1 Reagents: Benzenemethanaminium, N,N,N-triethyl-, (T-4)-tetrathioxomolybdate(2-) (2:1) Solvents: Acetonitrile ;  1 h, 28 °C

Reference

Propargyloxycarbonyl as a protecting group for the side chains of serine, threonine and tyrosine

Ramesh, Ramapanicker; et al, Journal of Chemical Sciences (Bangalore, 2008, 120(1), 163-173

Production Method 21

82911-71-5

2788-84-3

82911-78-2

Reaction Conditions

1.1 Catalysts: Sodium bicarbonate Solvents: Acetone

Reference

9-Fluorenylmethyl 1-benzotriazolyl carbonate

Wardrop, Duncan J.; et al, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001, ,

Production Method 22

28920-43-6

5680-80-8

82911-78-2

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: Methanol ,  Water ;  rt → 0 °C
1.2 0 °C → rt; overnight, 70 °C; 70 °C → rt
1.3 Reagents: Sodium bicarbonate Solvents: Water ;  rt

Reference

Synthesis of 2-Oxazolines by in Situ Desilylation and Cyclodehydration of β-Hydroxyamides

Brandstatter, Marco; et al, Journal of Organic Chemistry, 2015, 80(1), 40-51

Production Method 23

73724-45-5

18107-18-1

82911-78-2

Reaction Conditions

1.1 Solvents: Methanol ,  Hexane ;  rt
1.2 Reagents: Acetic acid ;  rt

Reference

Exploration of the Fluoride Reactivity of Aryltrifluoroborate on Selective Cleavage of Diphenylmethylsilyl Groups

Fujiki, Katsumasa; et al, European Journal of Organic Chemistry, 2020, 2020(29), 4616-4620

Fmoc-Ser-OMe Raw materials

• Methyl D-serinate
• L-Serine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(methyldiphenylsilyl)-, methyl ester
• (9H-Fluoren-9-yl)methyl 1H-Benzod1,2,3triazol-1-yl Carbonate
• (9H-fluoren-9-yl)methyl chloroformate
• Fmoc-Ser-OH
• Fmoc-OSu
• (diazomethyl)trimethylsilane
• L-Serine methyl ester hydrochloride
• L-Serine, methyl ester
• L-Serine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(triphenylmethyl)-, methyl ester

Fmoc-Ser-OMe Preparation Products

• Fmoc-Ser-OMe (82911-78-2)

• 1. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 2. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849
• 3. Distinct correlation between (CN2)x units and pores: a low-cost method for predesigned wide range control of micropore size of porous carbon?
  Xiaotong Feng,Lei Bian,Jie Ma,Lei Zhou,Xiayan Wang,Guangsheng Guo,Qiaosheng Pu Chem. Commun., 2019,55, 3963-3966
• 4. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
• 5. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739

• Solvents and Organic Chemicals Organic Compounds Acids/Esters

• 117398-49-9(Fmoc-Ala-OH (15N))
• 84000-07-7(Fmoc-N-Me-Ala-OH)
• 79990-15-1(Fmoc-D-Ala-OH)
• 296261-32-0(2-((((9H-Fluoren-9-yl)methoxy)-carbonyl)amino)malonic acid)
• 73724-45-5(Fmoc-Ser-OH)
• 83792-48-7(N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(phenylmethyl)-L-serine)
• 116861-26-8((((9H-Fluoren-9-yl)methoxy)carbonyl)-D-serine)
• 35661-38-2(Fmoc-DL-Ala-OH)
• 35661-39-3(Fmoc-Ala-OH)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)