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• Solvents and Organic Chemicals Organic Compounds Benzenoids Fluorenes Fluorenes
• Solvents and Organic Chemicals Organic Compounds Benzenoids Fluorenes

Introduction to Fmoc-DL-Ala-OH (CAS No. 35661-38-2)

Fmoc-DL-Ala-OH (CAS No. 35661-38-2) is a versatile amino acid derivative widely used in the field of peptide synthesis and medicinal chemistry. This compound, formally known as 9-Fluorenylmethoxycarbonyl-DL-alanine, is a key reagent in the solid-phase synthesis of peptides and proteins. Its unique properties make it an essential tool for researchers and scientists working in various areas of chemical and biological research.

The structure of Fmoc-DL-Ala-OH consists of a fluorenylmethoxycarbonyl (Fmoc) protecting group attached to the amino group of DL-alanine. The Fmoc group is particularly useful in peptide synthesis because it can be selectively removed under mild conditions, allowing for the sequential addition of amino acids without interfering with other functional groups in the growing peptide chain. This characteristic has made Fmoc-DL-Ala-OH a preferred choice in both academic and industrial settings.

Recent advancements in the field of peptide chemistry have further highlighted the importance of Fmoc-DL-Ala-OH. For instance, a study published in the Journal of Peptide Science demonstrated the use of Fmoc-protected amino acids, including Fmoc-DL-Ala-OH, in the development of novel therapeutic peptides. These peptides showed improved stability and bioavailability, making them promising candidates for treating various diseases such as cancer, diabetes, and neurodegenerative disorders.

In addition to its applications in therapeutic peptide synthesis, Fmoc-DL-Ala-OH has also found use in the development of diagnostic tools. Researchers at the University of California, San Francisco, utilized Fmoc-protected amino acids to create highly specific and sensitive biosensors for detecting biomarkers associated with early-stage diseases. The ability to precisely control the structure and reactivity of peptides using compounds like Fmoc-DL-Ala-OH has opened new avenues for early diagnosis and personalized medicine.

The synthesis of Fmoc-DL-Ala-OH involves several well-established chemical reactions. The first step typically involves the protection of DL-alanine with the Fmoc group using a coupling agent such as diisopropylcarbodiimide (DIC) or N,N'-dicyclohexylcarbodiimide (DCC). This reaction is followed by purification steps to ensure high purity and yield. The resulting product is a white crystalline solid that is highly stable under standard laboratory conditions.

In terms of safety and handling, Fmoc-DL-Ala-OH should be stored in a cool, dry place away from direct sunlight and sources of heat. It is important to handle this compound with care, using appropriate personal protective equipment (PPE) such as gloves and safety goggles. While not classified as a hazardous material, proper storage and handling practices are essential to maintain its integrity and ensure safe laboratory operations.

The market demand for Fmoc-DL-Ala-OH continues to grow due to its wide-ranging applications in research and development. Major suppliers such as Sigma-Aldrich, Thermo Fisher Scientific, and Alfa Aesar offer high-purity grades of this compound to meet the needs of both academic researchers and industrial scientists. The availability of high-quality reagents like Fmoc-DL-Ala-OH has significantly contributed to advancements in peptide chemistry and related fields.

In conclusion, Fmoc-DL-Ala-OH (CAS No. 35661-38-2) is a crucial reagent in modern peptide synthesis and medicinal chemistry. Its unique properties, coupled with recent advancements in research, make it an indispensable tool for scientists working on developing new therapeutic agents and diagnostic tools. As the field continues to evolve, the importance of compounds like Fmoc-DL-Ala-OH will only continue to grow.

• 111524-95-9((R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-phenylacetic acid)
• 84000-07-7(Fmoc-N-Me-Ala-OH)
• 29022-11-5(Fmoc-Gly-OH)
• 73724-45-5(Fmoc-Ser-OH)
• 83792-48-7(N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(phenylmethyl)-L-serine)
• 116861-26-8((((9H-Fluoren-9-yl)methoxy)carbonyl)-D-serine)
• 82911-78-2(Fmoc-Ser-OMe)
• 170642-27-0(Fmoc-D-Abu-OH)
• 146803-41-0(Fmoc-ala-aldehyde)
• 35661-39-3(Fmoc-Ala-OH)