Production Method 1

98-98-6

824-40-8

Reaction Conditions

1.1 Reagents: m-Chloroperbenzoic acid Solvents: Dichloromethane ;  20 min, 0 °C; 50 min, 0 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  0 °C → rt

Reference

Ligands for Copper-Catalyzed C-N Bond Forming Reactions with 1 Mol% CuBr as Catalyst

Yang, Kai; et al, Journal of Organic Chemistry, 2011, 76(9), 3151-3159

Production Method 2

98-98-6

824-40-8

Reaction Conditions

1.1 Reagents: Hydrogen peroxide Catalysts: Tungstate(7-), nonadeca-μ-oxoundecaoxo(μ-oxotetraoxodimolybdate)[μ11-[phosphato(… Solvents: Carbon tetrachloride ,  Water ;  6 h, reflux

Reference

Catalytic N-oxidation of picolinic acid in the presence of heteropoly acids containing molybdenum and tungsten

Bamoharram, Fatemeh F.; et al, Journal of Molecular Catalysis A: Chemical, 2007, 267(1-2), 241-244

Production Method 3

1008-89-5

824-40-8

Reaction Conditions

1.1 Reagents: Potassium peroxymonosulfate sulfate (2KHSO5.KHSO4.K2SO4) Catalysts: Ruthenium trichloride Solvents: Water-d2 ;  20 h, 50 °C

Reference

Co(II), a catalyst for selective conversion of phenyl rings to carboxylic acid groups

Sinha, Shashi Bhushan; et al, RSC Advances, 2014, 4(90), 49395-49399

Production Method 4

109-06-8

824-40-8

Reaction Conditions

1.1 Reagents: Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Water ;  rt → 70 °C; 70 °C; 30 min, 75 - 85 °C
2.1 Reagents: Hydrogen ion
2.2 Reagents: Hydrogen peroxide Solvents: Acetic acid ,  Water ;  cooled; 24 h, 70 - 75 °C

Reference

Synthesis of 4-nitro-2-pyridinecarboxylic acid hydrazide 1-oxide

Shi, Li-xin, Shangqiu Shifan Xueyuan Xuebao, 2007, 23(6), 70-72

Production Method 5

1452-63-7

824-40-8

Reaction Conditions

1.1 -
2.1 Reagents: Hydrogen peroxide

Reference

Stable diacylhydrazines

Talik, Tadeusz; et al, Prace Naukowe Akademii Ekonomicznej imienia Oskara Langego we Wroclawiu, 1984, 255, 131-6

Production Method 6

4467-06-5

824-40-8

Reaction Conditions

1.1 Reagents: Potassium peroxymonosulfate sulfate (2KHSO5.KHSO4.K2SO4) Catalysts: Borate(1-), tetrafluoro-, cobalt(2+) (2:1) Solvents: Water-d2 ;  3 h, 50 °C
2.1 Reagents: Potassium peroxymonosulfate sulfate (2KHSO5.KHSO4.K2SO4) Catalysts: Borate(1-), tetrafluoro-, cobalt(2+) (2:1) Solvents: Water-d2 ;  4 h, 40 °C

Reference

Co(II), a catalyst for selective conversion of phenyl rings to carboxylic acid groups

Sinha, Shashi Bhushan; et al, RSC Advances, 2014, 4(90), 49395-49399

Production Method 7

5957-90-4

824-40-8

Reaction Conditions

1.1 Reagents: Potassium peroxymonosulfate sulfate (2KHSO5.KHSO4.K2SO4) Catalysts: Borate(1-), tetrafluoro-, cobalt(2+) (2:1) Solvents: Water-d2 ;  3 h, 50 °C
2.1 Reagents: Potassium peroxymonosulfate sulfate (2KHSO5.KHSO4.K2SO4) Catalysts: Borate(1-), tetrafluoro-, cobalt(2+) (2:1) Solvents: Water-d2 ;  4 h, 40 °C

Reference

Co(II), a catalyst for selective conversion of phenyl rings to carboxylic acid groups

Sinha, Shashi Bhushan; et al, RSC Advances, 2014, 4(90), 49395-49399

Production Method 8

98-98-6

824-40-8

Reaction Conditions

1.1 Reagents: Peracetic acid ,  Hydrogen peroxide Solvents: Acetic acid ,  Methanol

Reference

N-Oxide substituted picolinic acids

Profft, E.; et al, Journal fuer Praktische Chemie (Leipzig), 1961, 13, 58-75

Production Method 9

2524-52-9

824-40-8

Reaction Conditions

1.1 Reagents: Peracetic acid ,  Hydrogen peroxide Solvents: Acetic acid

Reference

Derivatives of picolinic acid N-oxide

Krause, Hans Walter; et al, Chemische Berichte, 1959, 92, 155-60

Production Method 10

840-79-9

824-40-8

Reaction Conditions

1.1 Reagents: Hydrogen peroxide

Reference

Stable diacylhydrazines

Talik, Tadeusz; et al, Prace Naukowe Akademii Ekonomicznej imienia Oskara Langego we Wroclawiu, 1984, 255, 131-6

Production Method 11

1452-77-3

824-40-8

Reaction Conditions

1.1 Reagents: Hydrogen peroxide Solvents: Acetic acid

Reference

Synthesis of compounds for chemotherapy of tuberculosis. VII. Pyridine N-oxides with sulfur-containing groups

Gardner, T. S.; et al, Journal of Organic Chemistry, 1957, 22, 984-6

Production Method 12

25108-36-5

824-40-8

Reaction Conditions

1.1 Reagents: Hydrogen ion
1.2 Reagents: Hydrogen peroxide Solvents: Acetic acid ,  Water ;  cooled; 24 h, 70 - 75 °C

Reference

Synthesis of 4-nitro-2-pyridinecarboxylic acid hydrazide 1-oxide

Shi, Li-xin, Shangqiu Shifan Xueyuan Xuebao, 2007, 23(6), 70-72

Production Method 13

75003-55-3

824-40-8

Reaction Conditions

1.1 Reagents: Hydrogen peroxide Catalysts: Acetic acid

Reference

Studies on tertiary amine oxides. LXVII. Reactions of aromatic N-oxides with 3-arylrhodanines in the presence of acetic anhydride

Yousif, Mohammed M.; et al, Journal of Heterocyclic Chemistry, 1980, 17(2), 305-9

Production Method 14

109-06-8

824-40-8

Reaction Conditions

1.1 Reagents: Potassium peroxymonosulfate sulfate (2KHSO5.KHSO4.K2SO4) Catalysts: Borate(1-), tetrafluoro-, cobalt(2+) (2:1) Solvents: Water-d2 ;  4 h, 70 °C
2.1 Reagents: Potassium peroxymonosulfate sulfate (2KHSO5.KHSO4.K2SO4) Catalysts: Borate(1-), tetrafluoro-, cobalt(2+) (2:1) Solvents: Water-d2 ;  4 h, 40 °C

Reference

Co(II), a catalyst for selective conversion of phenyl rings to carboxylic acid groups

Sinha, Shashi Bhushan; et al, RSC Advances, 2014, 4(90), 49395-49399

Production Method 15

127406-56-8

824-40-8

Reaction Conditions

1.1 Reagents: Potassium peroxymonosulfate sulfate (2KHSO5.KHSO4.K2SO4) Catalysts: Borate(1-), tetrafluoro-, cobalt(2+) (2:1) Solvents: Water-d2 ;  4 h, 50 °C
2.1 Reagents: Potassium peroxymonosulfate sulfate (2KHSO5.KHSO4.K2SO4) Catalysts: Borate(1-), tetrafluoro-, cobalt(2+) (2:1) Solvents: Water-d2 ;  4 h, 40 °C

Reference

Co(II), a catalyst for selective conversion of phenyl rings to carboxylic acid groups

Sinha, Shashi Bhushan; et al, RSC Advances, 2014, 4(90), 49395-49399

Production Method 16

1121-60-4

824-40-8

98-98-6

Reaction Conditions

1.1 Reagents: Sodium acetate ,  Hydrogen peroxide Catalysts: Acetone ,  Manganese perchlorate hexahydrate Solvents: Acetone ;  cooled; 16 h, rt

Reference

Manganese catalyzed cis-dihydroxylation of electron deficient alkenes with H2O2

Saisaha, Pattama; et al, Organic & Biomolecular Chemistry, 2010, 8(19), 4444-4450

Production Method 17

100-70-9

824-40-8

2402-98-4

Reaction Conditions

1.1 Reagents: Hydrogen peroxide Catalysts: Tungstate(8-), (aquadizincate)tetracosa-μ-oxotetra-μ4-oxoundecaoxoundeca-, ammon… Solvents: Water ;  4 h, 353 K

Reference

A water soluble heteropolyoxotungstate as a selective, efficient and environment friendly oxidation catalyst

Maity, Prasenjit; et al, Journal of Chemical Sciences (Bangalore, 2009, 121(4), 377-385

Production Method 18

1121-60-4

824-40-8

76037-09-7

7216-40-2

Reaction Conditions

1.1 Reagents: Dimethyldioxirane Solvents: Acetone

Reference

Dioxirane epoxidation of alkenes

Adam, Waldemar; et al, Organic Reactions (Hoboken, 2002, 61,

Production Method 19

1121-60-4

824-40-8

98-98-6

76037-09-7

7216-40-2

Reaction Conditions

1.1 Reagents: Dimethyldioxirane Solvents: Acetone

Reference

Dioxirane epoxidation of alkenes

Adam, Waldemar; et al, Organic Reactions (Hoboken, 2002, 61,

Picolinic Acid N-Oxide Raw materials

• Picolinic acid
• 2-Phenylpyridine
• pyridine-2-carbaldehyde
• 2-Pyridinecarbohydrazide
• N,N'-Dipyridoylhydrazine
• Picolinamide
• pyridine-2-carbonitrile
• 4-(pyridin-2-yl)benzaldehyde
• Ethyl picolinate
• 2-(p-Tolyl)pyridine
• 2-Methylpyridine
• 2-Pyridinecarboxylicacid, potassium salt (1:1)
• 2-(4-Methoxyphenyl)pyridine
• 4-Thiazolidinone, 3-phenyl-5-(2-pyridinyl)-2-thioxo-

Picolinic Acid N-Oxide Preparation Products

• Picolinic acid (98-98-6)
• 2-Pyridinecarbonitrile,1-oxide (2402-98-4)
• METHANEDIOL, (1-OXIDO-2-PYRIDINYL)- (76037-09-7)
• 2-Pyridinecarboxaldehyde, 1-oxide (7216-40-2)
• Picolinic Acid N-Oxide (824-40-8)

• 1. Alternative donor substrates for inverting and retaining glycosyltransferases?
  Luke L. Lairson,Warren W. Wakarchuk Chem. Commun., 2007, 365-367
• 2. Alternative synthesis of the anti-baldness compound RU58841?
  RSC Adv., 2014,4, 14143-14148
• 3. Aluminium complexes with thio-phosphorus ligands: syntheses and characterisations of [Al2(CyPS3)2(CyPHS2)2] and [Al(S2PPh2)3]?
  Robert P. Davies,Maria A. Giménez,Laura Patel,Andrew J. P. White Dalton Trans., 2008, 5705-5707
• 4. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 5. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids
• Other Chemical Reagents

• 13509-63-2(2-Pyridinecarboxylic acid, 5-ethyl-, 1-oxide)
• 16830-32-3(dipyrNO)
• 83199-81-9(3-Methyl-pyridine-3-carboxylic acid N-oxide)
• 38195-81-2(2-Pyridinecarboxylicacid, methyl ester, 1-oxide)
• 16264-71-4(1H-Indole-2-carboxylicacid, 1-hydroxy-)
• 15905-16-5(1-oxidopyridin-1-ium-2,6-dicarboxylic acid)
• 1125-34-4(2-Pyridinecarboxylicacid, 6-methyl-, 1-oxide)
• 30062-31-8(2-Pyridinecarboxylic acid, ethyl ester, 1-oxide)
• 401792-77-6(5-Methyl-1-oxy-pyridine-2-carboxylic acid methyl ester)
• 1128-18-3(2-Pyridinecarboxylic acid, 4-bromo-6-methyl-, 1-oxide)