Production Method 1

86108-58-9

81015-49-8

Reaction Conditions

1.1 Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Toluene ;  overnight, reflux
1.2 Reagents: Hydrogen bromide Solvents: Water ;  2 h, reflux

Reference

New potent C2-Symmetric malaria plasmepsin I and II inhibitors

Oscarsson, Karin; et al, Bioorganic & Medicinal Chemistry, 2003, 11(7), 1235-1246

Production Method 2

25984-63-8

7252-83-7

81015-49-8

Reaction Conditions

1.1 Reagents: p-Toluenesulfonic acid Solvents: Ethanol ;  rt; 24 h, 90 °C

Reference

Preparation of nitrogen-containing heterocycles as antifibrotic agents for the treatment of tissue and organ fibrosis

, Argentina, , ,

Production Method 3

874-90-8

81015-49-8

Reaction Conditions

1.1 Reagents: Magnesium chloride ,  Sodium hydrosulfide Solvents: Dimethylformamide ,  Water ;  8 h, rt
2.1 Solvents: Ethanol ;  10 h, reflux
3.1 Reagents: Hydrogen bromide Solvents: Acetic acid ,  Water ;  24 h, reflux

Reference

Design, synthesis, and in vitro antitumor evaluation of novel diaryl urea derivatives

Sun, Min; et al, European Journal of Medicinal Chemistry, 2010, 45(6), 2299-2306

Production Method 4

27088-84-2

81015-49-8

Reaction Conditions

1.1 Reagents: Hydrogen bromide Solvents: Acetic acid ,  Water ;  24 h, reflux

Reference

Design, synthesis, and in vitro antitumor evaluation of novel diaryl urea derivatives

Sun, Min; et al, European Journal of Medicinal Chemistry, 2010, 45(6), 2299-2306

Production Method 5

3034-53-5

81015-49-8

Reaction Conditions

1.1 Reagents: 1,2-Dibromoethane ,  Zinc Solvents: Tetrahydrofuran
1.2 Reagents: Chlorotrimethylsilane Solvents: Tetrahydrofuran
1.3 Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Tetrahydrofuran
1.4 Reagents: Sodium chloride
1.5 Solvents: Dichloromethane

Reference

Preparation of 2- and 5-aryl-substituted thiazoles via palladium-catalyzed Negishi cross-coupling

Jensen, Jacob; et al, Synthesis, 2001, (1), 128-134

Production Method 6

2362-64-3

2032-35-1

81015-49-8

Reaction Conditions

1.1 Solvents: Ethanol ;  10 h, reflux
2.1 Reagents: Hydrogen bromide Solvents: Acetic acid ,  Water ;  24 h, reflux

Reference

Design, synthesis, and in vitro antitumor evaluation of novel diaryl urea derivatives

Sun, Min; et al, European Journal of Medicinal Chemistry, 2010, 45(6), 2299-2306

4-(2-Thiazolyl)phenol Raw materials

• 4-Methoxybenzonitrile
• 4-methoxybenzene-1-carbothioamide
• 2-Bromo-1,1-diethoxyethane
• 4-Hydroxythiobenzamide
• Thiazole, 2-(trimethylstannyl)-
• Bromoacetaldehyde dimethyl acetal
• 2-Bromothiazole
• Thiazole, 2-(4-methoxyphenyl)-

4-(2-Thiazolyl)phenol Preparation Products

• 4-(2-Thiazolyl)phenol (81015-49-8)

• 1. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 2. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 3. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583
• 4. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 5. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755

• 1826-11-5(2-Phenylthiazole)
• 27088-83-1(2-(p-Tolyl)thiazole)
• 42156-17-2(Thiazole,2-(4-ethylphenyl)-)
• 184847-97-0(3-(1,3-thiazol-2-yl)phenylmethanol)
• 454678-91-2((4-Thiazol-2-yl-phenyl)-methanol)
• 42156-13-8(2-(m-Tolyl)thiazole)
• 827-45-2(2-Phenyl-1,3-thiazol-4-ol)
• 198904-53-9(4-Thiazol-2-yl-benzaldehyde)
• 138330-01-5(4-(4-methyl-1,3-thiazol-2-yl)phenol)
• 885465-97-4(3-(1,3-thiazol-2-yl)benzaldehyde)