Production Method 1

1117-97-1

98-89-5

80783-98-8

Reaction Conditions

1.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Dichloromethane ;  rt; 1 h, rt
1.2 16 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Water

Reference

Enolizable β-Fluoroenones: Synthesis and Asymmetric 1,2-Reduction

Zygalski, Lukas; et al, Organic Letters, 2018, 20(16), 5071-5074

Production Method 2

1117-97-1

98-89-5

80783-98-8

Reaction Conditions

1.1 Solvents: Toluene ;  10 min, 0 °C
1.2 Reagents: Phosphorus trichloride Solvents: Toluene ;  0 °C; 0 °C → rt; 0.5 h, 60 °C; 60 °C → rt
1.3 Reagents: Sodium bicarbonate Solvents: Water ;  rt

Reference

One-pot transition-metal-free synthesis of Weinreb amides directly from carboxylic acids

Niu, Teng; et al, Synthesis, 2014, 46(3), 320-330

Production Method 3

2719-27-9

6638-79-5

80783-98-8

Reaction Conditions

1.1 Solvents: Dichloromethane ;  rt → 0 °C
1.2 Reagents: Triethylamine ;  0 °C → 10 °C; 10 °C → 0 °C
1.3 < 7 °C; 65 h, rt
1.4 Solvents: Water ;  rt

Reference

Reactions between Weinreb Amides and 2-Magnesiated Oxazoles: A Simple and Efficient Preparation of 2-Acyl Oxazoles

Pippel, Daniel J.; et al, Journal of Organic Chemistry, 2007, 72(15), 5828-5831

Production Method 4

2719-27-9

6638-79-5

80783-98-8

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  cooled; 17 h, rt

Reference

Catalytic enantioselective construction of β-quaternary carbons via a conjugate addition of cyanide to β,β-disubstituted α,β-unsaturated carbonyl compounds

Tanaka, Yuta; et al, Journal of the American Chemical Society, 2010, 132(26), 8862-8863

Production Method 5

30289-28-2

98-89-5

80783-98-8

Reaction Conditions

1.1 Reagents: Triethylamine Catalysts: 4-(Dimethylamino)pyridine Solvents: Acetonitrile

Reference

An efficient synthesis of N-methoxy-N-methylamides from carboxylic acids using N-methoxy-N-methylcarbamoyl chloride

Lee, Jae In; et al, Bulletin of the Korean Chemical Society, 2002, 23(3), 521-524

Production Method 6

1117-97-1

2719-27-9

80783-98-8

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  rt → 0 °C; 0 °C
1.2 1 h, 0 °C

Reference

A new synthesis of cyclohexyl-3-fluorobenzylone

Zhou, Xiao-ping; et al, Fenzi Kexue Xuebao, 2005, 21(2), 60-62

Production Method 7

1117-97-1

2719-27-9

80783-98-8

Reaction Conditions

Reference

N-Methoxy-N-methylamides as effective acylating agents

Nahm, Steven; et al, Tetrahedron Letters, 1981, 22(39), 3815-18

Production Method 8

931-51-1

80783-98-8

Reaction Conditions

1.1 Solvents: Tetrahydrofuran ;  rt; 15 min, -15 °C; 5 min, -15 °C
1.2 Reagents: Ammonium chloride Solvents: Water

Reference

A novel synthesis of N-methoxy-N-methylamides from 4,6-pyrimidyl urethane and Grignard reagents

Lee, Jae In, Bulletin of the Korean Chemical Society, 2007, 28(4), 695-697

Production Method 9

2043-61-0

6638-79-5

80783-98-8

Reaction Conditions

1.1 Reagents: Pivalic acid ,  Pyridine ,  tert-Butyl hypochlorite Catalysts: Tempo Solvents: Acetonitrile ;  20 min, 0 °C; 1 h
1.2 25 °C

Reference

Organocatalytic oxidation of aldehydes to mixed anhydrides

Toledo, Hila; et al, Chemical Communications (Cambridge, 2013, 49(39), 4367-4369

Production Method 10

30289-28-2

1193-24-4

80783-98-8

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  48 h, rt
2.1 Solvents: Tetrahydrofuran ;  rt; 15 min, -15 °C; 5 min, -15 °C
2.2 Reagents: Ammonium chloride Solvents: Water

Reference

A novel synthesis of N-methoxy-N-methylamides from 4,6-pyrimidyl urethane and Grignard reagents

Lee, Jae In, Bulletin of the Korean Chemical Society, 2007, 28(4), 695-697

Production Method 11

6638-79-5

55277-90-2

80783-98-8

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  1 h, 0 °C
2.1 Solvents: Tetrahydrofuran ;  rt → 0 °C; 10 min, 0 °C; 0.5 h, 0 °C
2.2 Reagents: Ammonium chloride Solvents: Water

Reference

A new synthesis of N-methoxy-N-methylamides from S-2-pyridyl thiocarbamate and Grignard reagents

Lee, Jae In; et al, Journal of the Korean Chemical Society, 2005, 49(6), 609-612

Production Method 12

1117-97-1

98-89-5

80783-98-8

Reaction Conditions

1.1 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ;  rt; 1 h, rt
1.2 16 h, rt

Reference

Asymmetric alkene-alkene reductive cross-coupling reaction via visible-light photoredox/cobalt dual catalysis

Maiti, Mamata; et al, Chemical Communications (Cambridge, 2023, 59(64), 9718-9721

Production Method 13

4630-82-4

1117-97-1

80783-98-8

Reaction Conditions

1.1 Solvents: Tetrahydrofuran ;  rt; rt → -20 °C
1.2 Reagents: Chloro(1-methylethyl)magnesium ;  15 min, -20 °C; 10 h, -20 °C
1.3 Reagents: Ammonium chloride Solvents: Diethyl ether ,  Water

Reference

Copper(I)-Catalyzed Enantioselective Nucleophilic Borylation of Aliphatic Ketones: Synthesis of Enantioenriched Chiral Tertiary α-Hydroxyboronates

Kubota, Koji ; et al, Angewandte Chemie, 2017, 56(23), 6646-6650

Production Method 14

2719-27-9

6638-79-5

80783-98-8

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Diethyl ether ,  Water ;  2 min, 0 °C; 1 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water

Reference

Three-Step Synthetic Pathway toward Fully Decorated [1,2,3]Triazolo[4,5-d]pyrimidine (8-Azapurine) Derivatives

Reniers, Felien ; et al, Organic Letters, 2023, 25(16), 2820-2824

Production Method 15

98-89-5

6638-79-5

80783-98-8

Reaction Conditions

1.1 Reagents: Triethylamine ,  Diphosgene Solvents: Dichloromethane ;  0 °C
1.2 0 °C → rt

Reference

An efficient one-pot synthesis of N-methoxy-N-methylamides from carboxylic acids

Kim, Misoo; et al, Synthetic Communications, 2003, 33(23), 4013-4018

Production Method 16

98-89-5

6638-79-5

80783-98-8

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane
1.2 Reagents: Tributylphosphine ,  Dipyrithione

Reference

A mild, one-pot method for the conversion of carboxylic acids into the corresponding Weinreb amides

Banwell, Martin; et al, Synthetic Communications, 2001, 31(13), 2011-2019

Production Method 17

98-89-5

6638-79-5

80783-98-8

Reaction Conditions

1.1 Reagents: 4-(Dimethylamino)pyridine ,  S,S-Di-2-pyridinyl carbonodithioate Solvents: Acetonitrile
1.2 Reagents: Triethylamine
1.3 Solvents: Tetrahydrofuran
1.4 Solvents: Hexane ,  Ethyl acetate

Reference

A convenient synthesis of N-methoxy-N-methylamides from carboxylic acids using S,S-di-2-pyridyl dithiocarbonate

Lee, Jae In; et al, Bulletin of the Korean Chemical Society, 2001, 22(4), 421-423

Production Method 18

1062512-43-9

98-89-5

80783-98-8

Reaction Conditions

1.1 Solvents: Toluene ;  0.5 - 1 h, 60 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  rt

Reference

A powerful reagent for synthesis of Weinreb amides directly from carboxylic acids

Niu, Teng; et al, Organic Letters, 2009, 11(19), 4474-4477

Production Method 19

4630-82-4

6638-79-5

80783-98-8

Reaction Conditions

1.1 Reagents: Chloro(1-methylethyl)magnesium Solvents: Tetrahydrofuran

Reference

A new general method for preparation of N-methoxy-N-methylamides. Application in direct conversion of an ester to a ketone

Williams, J. Michael; et al, Tetrahedron Letters, 1995, 36(31), 5461-4

Production Method 20

4630-82-4

6638-79-5

80783-98-8

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ;  25 min, 22 °C
1.2 Reagents: [μ-(1,4-Diazabicyclo[2.2.2]octane-κN1:κN4)]hexamethyldialuminum Solvents: Tetrahydrofuran ;  16 min, 130 °C
1.3 Reagents: Hydrochloric acid Solvents: Water

Reference

Microwave acceleration in DABAL-Me3-mediated amide formation

Glynn, Daniel; et al, Tetrahedron Letters, 2008, 49(39), 5687-5688

Production Method 21

931-51-1

912457-54-6

80783-98-8

Reaction Conditions

1.1 Solvents: Tetrahydrofuran ;  rt → 0 °C; 10 min, 0 °C; 0.5 h, 0 °C
1.2 Reagents: Ammonium chloride Solvents: Water

Reference

A new synthesis of N-methoxy-N-methylamides from S-2-pyridyl thiocarbamate and Grignard reagents

Lee, Jae In; et al, Journal of the Korean Chemical Society, 2005, 49(6), 609-612

Production Method 22

1117-97-1

80783-98-8

Reaction Conditions

1.1 Reagents: N,O-Dimethylhydroxylamine hydrochloride ,  Phosphorus trichloride Solvents: Diethyl ether ;  0 °C; 0 °C → rt; overnight, rt; 4 h, reflux
2.1 Solvents: Toluene ;  0.5 - 1 h, 60 °C
2.2 Reagents: Sodium bicarbonate Solvents: Water ;  rt

Reference

A powerful reagent for synthesis of Weinreb amides directly from carboxylic acids

Niu, Teng; et al, Organic Letters, 2009, 11(19), 4474-4477

N-methoxy-N-methylcyclohexanecarboxamide Raw materials

• Methyl cyclohexanecarboxylate
• N,O-Dimethylhydroxylamine
• N-Methoxy-N-methylcarbamoyl Chloride
• Cyclohexylmagnesium chloride
• N,N',N''-phosphinetriyltris(N,O-dimethylhydroxylamine)
• Cyclohexanecarboxylic acid
• Carbamothioic acid, methoxymethyl-, S-2-pyridinyl ester
• cyclohexanecarbaldehyde
• 6-hydroxy-3,4-dihydropyrimidin-4-one
• cyclohexanecarbonyl chloride
• N,O-Dimethylhydroxylamine hydrochloride
• CARBONODITHIOIC ACID, S,S-DI-2-PYRIDINYL ESTER

N-methoxy-N-methylcyclohexanecarboxamide Preparation Products

• N-methoxy-N-methylcyclohexanecarboxamide (80783-98-8)

• 1. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 2. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 3. Fc microparticles can modulate the physical extent and magnitude of complement activity?
  David White,Sean R. Stowell Biomater. Sci., 2017,5, 463-474
• 4. Enabling non-flammable Li-metal batteries via electrolyte functionalization and interface engineering?
  Jing Yu,Yu-Qi Lyu,Jiapeng Liu,Mohammed B. Effat,Junxiong Wu J. Mater. Chem. A, 2019,7, 17995-18002
• 5. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives

• 158243-50-6(Cyclohexanecarboxamide, 4-(1,1-dimethylethyl)-N-methoxy-N-methyl-,trans-)
• 158243-51-7(Cyclohexanecarboxamide, 4-(1,1-dimethylethyl)-N-methoxy-N-methyl-,cis-)
• 167303-65-3(N-methoxy-N-methylcyclopentanecarboxamide)
• 134560-43-3(Cyclohexaneacetamide, N-methoxy-N-methyl-)
• 640768-72-5(N-methoxy-N-methylcyclobutanecarboxamide)
• 192644-20-5(Cyclopropanecarboxamide,N-methoxy-N,2-dimethyl-)
• 1330165-35-9((2S)-N-Methoxy-N,2-dimethylhexanamide-d3)
• 915280-91-0(Cyclopropanecarboxamide, 2-formyl-N-methoxy-N-methyl-)
• 158243-61-9(Butanamide, N-methoxy-N,2-dimethyl-)
• 253429-08-2(N-methoxy-N-methylcycloheptanecarboxamide)