Production Method 1

72-18-4

78-81-9

Reaction Conditions

1.1 Catalysts: Isophorone Solvents: Isopropanol ;  24 h, 150 °C

Reference

Organocatalytic Decarboxylation of Amino Acids as a Route to Bio-based Amines and Amides

Claes, Laurens ; Janssen, Michiel ; De Vos, Dirk E., ChemCatChem, 2019, 11(17), 4297-4306

Production Method 2

78-81-9

Reaction Conditions

1.1 Catalysts: Palladium alloy, base, Pd 81,Ni 19 (graphene-supported) Solvents: Methanol ,  Water ;  5 min, rt
1.2 Reagents: Ammonia borane ;  5 min, rt

Reference

Tandem Dehydrogenation of Ammonia Borane and Hydrogenation of Nitro/Nitrile Compounds Catalyzed by Graphene-Supported NiPd Alloy Nanoparticles

Goksu, Haydar; Ho, Sally Fae; Metin, Onder; Korkmaz, Katip; Mendoza Garcia, Adriana; et al, ACS Catalysis, 2014, 4(6), 1777-1782

Production Method 3

78-81-9

Reaction Conditions

1.1 Reagents: Hydrogen ,  Ammonia Catalysts: Cobalt Solvents: Tetrahydrofuran ,  Water ;  5 bar, rt; 5 min, rt → 110 °C; 4 h, 110 °C

Reference

High performance of nitrogen-doped carbon-supported cobalt catalyst for the mild and selective synthesis of primary amines

Liu, Xixi; Wang, Yanxin; Jin, Shiwei; Li, Xun; Zhang, Zehui, Arabian Journal of Chemistry, 2020, 13(4), 4916-4925

Production Method 4

115074-49-2

78-81-9

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Methanol ;  20 min, 23 °C

Reference

Structure-Based Design of Novel HIV-1 Protease Inhibitors To Combat Drug Resistance

Ghosh, Arun K.; Sridhar, Perali Ramu; Leshchenko, Sofiya; Hussain, Azhar K.; Li, Jianfeng; et al, Journal of Medicinal Chemistry, 2006, 49(17), 5252-5261

Production Method 5

78-81-9

Reaction Conditions

1.1 Reagents: Sodium borohydride Catalysts: Iron oxide (Fe3O4) ,  Carbon (acidified, carboxylated) ,  (SP-4-3)-Dichloro(1,7-phenanthroline-κN7)[1,1′-(sulfinyl-κS)bis[methane]]platinu… Solvents: Water ;  30 min, 95 °C

Reference

Chemoselective Reduction of Nitro and Nitrile Compounds with Magnetic Carbon Nanotubes-Supported Pt(II) Catalyst under Mild Conditions

Tabatabaei Rezaei, Seyed Jamal ; Khorramabadi, Hossein; Hesami, Ali; Ramazani, Ali ; Amani, Vahid; et al, Industrial & Engineering Chemistry Research, 2017, 56(43), 12256-12266

Production Method 6

926-62-5

78-81-9

Reaction Conditions

1.1 Solvents: Diethyl ether

Reference

Electrophilic amination of carbanions, enolates, and their surrogates

Ciganek, Engelbert, Organic Reactions (Hoboken, 2008, 72, 1-366

Production Method 7

78-81-9

Reaction Conditions

1.1 Reagents: Sodium borohydride Catalysts: Nickel dichloride Solvents: Water ;  1 h, 95 °C

Reference

Chemo-selective reduction of nitro and nitrile compounds using Ni nanoparticles immobilized on hyperbranched polymer-functionalized magnetic nanoparticles

Tabatabaei Rezaei, Seyed Jamal ; Mashhadi Malekzadeh, Asemeh; Poulaei, Sima; Ramazani, Ali ; Khorramabadi, Hossein, Applied Organometallic Chemistry, 2018, 32(1),

Production Method 8

78-81-9

Reaction Conditions

1.1 Reagents: Ammonia Catalysts: Nickel Solvents: 2-Methyl-2-butanol ;  18 h, 7 bar, 170 °C

Reference

Primary amines from lignocellulose by direct amination of alcohol intermediates, catalyzed by RANEY Ni

Wu, Xianyuan; De Bruyn, Mario; Barta, Katalin, Catalysis Science & Technology, 2022, 12(19), 5908-5916

Production Method 9

78-81-9

Reaction Conditions

1.1 Reagents: Sodium triethylborohydride Catalysts: (T-4)-[2-[Bis(1-methylethyl)phosphino-κP]-N-[[3-[bis(1-methylethyl)phosphino]phe… Solvents: Toluene ;  rt; 20 min, rt
1.2 Reagents: Hydrogen ,  Potassium bis(trimethylsilyl)amide Solvents: Toluene ;  48 h, 60 bar, 140 °C

Reference

Selective hydrogenation of nitriles to primary amines catalyzed by a novel iron complex

Chakraborty, Subrata; Leitus, Gregory; Milstein, David, Chemical Communications (Cambridge, 2016, 52(9), 1812-1815

Production Method 10

78-81-9

Reaction Conditions

Reference

A new synthesis of N-alkylated 3,3-dialkylpiperidines

Feichtinger, Hans; Payer, Wolfgang; Cornils, Boy, Chemische Berichte, 1978, 111(5), 1721-32

Production Method 11

110-96-3

78-81-9

Reaction Conditions

1.1 Reagents: Ammonia Catalysts: Tetracarbonyl-μ-hydro[(1,2,3,4,5-η)-1-hydroxylato-2,3,4,5-tetraphenyl-2,4-cyclop… Solvents: 2-Methyl-2-butanol ,  tert-Butyl methyl ether ,  Water ;  16 h, 170 °C; cooled

Reference

Synthesis of primary amines from secondary and tertiary amines: ruthenium-catalyzed amination using ammonia

Baehn, Sebastian; Imm, Sebastian; Neubert, Lorenz; Zhang, Min; Neumann, Helfried; et al, Chemistry - A European Journal, 2011, 17(17), 4705-4708

Production Method 12

78-81-9

Reaction Conditions

1.1 Solvents: Methanol ,  Water ;  72 h, rt

Reference

Hydrolysis and Hydrogenolysis of Formamidines: N,N-Dimethyl and N,N-Dibenzyl Formamidines as Protective Groups for Primary Amines

Vincent, Stephane; Mioskowski, Charles; Lebeau, Luc, Journal of Organic Chemistry, 1999, 64(3), 991-997

Production Method 13

1522-06-1

78-81-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Nickel

Reference

Catalytic hydrogenation and hydrogenating distillation of azines on Raney nickel

Beregi, Ladislas, Compt. rend., 1947, 224, 1508-9

Production Method 14

78-81-9

Reaction Conditions

1.1 Reagents: Sodium Solvents: Ethanol ,  Toluene

Reference

Reduction of cyanides

Walter, L. A.; McElvain, S. M., Journal of the American Chemical Society, 1934, 56, 1614-16

2-methylpropan-1-amine Raw materials

• L-Valine
• Isobutylmagnesium Bromide
• Diisobutylamine
• Propanal, 2-methyl-, (2E)-2-[(2-methylpropylidene)]hydrazone, (1E)- (9CI)
• 2-Cyclopenten-1-ol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, acetate,(1R,4S)-

2-methylpropan-1-amine Preparation Products

• 2-methylpropan-1-amine (78-81-9)

• 1. Distinct roles of SNARE-mimicking lipopeptides during initial steps of membrane fusion?
  Alena Koukalová,?árka Pokorná,Aimee L. Boyle,Nestor Lopez Mora,Alexander Kros,Martin Hof,Radek ?achl Nanoscale, 2018,10, 19064-19073
• 2. Fe3O4 nanosphere@microporous organic networks: enhanced anode performances in lithium ion batteries through carbonization?
  Byungho Lim,Jaewon Jin,Jin Yoo,Seung Yong Han,Kyeongyeol Kim,Sungah Kang,Nojin Park,Sang Moon Lee,Hae Jin Kim,Seung Uk Son Chem. Commun., 2014,50, 7723-7726
• 3. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 4. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
• 5. Fe3O4/Au/Fe3O4 nanoflowers exhibiting tunable saturation magnetization and enhanced bioconjugation
  Feng Shi,Kunping Yan,Mingli Peng,Xiao Cheng,Yanling Luo,Xuemei Chen,V. A. L. Roy,Zuankai Wang Nanoscale, 2012,4, 747-751

• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Primary amines
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

• 923560-91-2(1-Propanamine, 2-methyl-, magnesium salt (2:1))
• 1219799-03-7(2-METHYLPROPYL-D9-AMINE HCL)
• 7328-91-8(2,2-Dimethylpropanediamine)
• 2400-78-4(2-Methylpropane-1,3-diamine)
• 90387-44-3(Formaldehyde, reaction products with 2-methyl-1-propanamine)
• 5813-64-9(2,2-Dimethylpropan-1-amine)
• 5041-09-8(2-Methylpropan-1-amine Hydrochloride)
• 15995-42-3(2-(aminomethyl)-2-methylpropane-1,3-diamine)
• 1146967-64-7(2-Methylpropyl-d9-amine)
• 15925-18-5(2,2-Dimethyl-1-propanamine hydrochloride)