• 1. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 2. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
• 3. Evolution and characterization of a benzylguanine-binding RNA aptamer?
  J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552
• 4. Distinct roles of SNARE-mimicking lipopeptides during initial steps of membrane fusion?
  Alena Koukalová,?árka Pokorná,Aimee L. Boyle,Nestor Lopez Mora,Alexander Kros,Martin Hof,Radek ?achl Nanoscale, 2018,10, 19064-19073
• 5. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608

• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Primary amines
• Material Chemicals Electrical Materials Biosensor Materials
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides
• Material Chemicals Electrical Materials

2-Methylpropan-1-amine Hydrochloride (CAS No. 5041-09-8): A Comprehensive Overview

2-Methylpropan-1-amine Hydrochloride, commonly referenced by its CAS No. 5041-09-8, is a versatile organic compound classified as a tertiary amine salt with significant applications in pharmaceutical, biochemical, and industrial contexts. This compound, chemically represented as C₄H₁₁N·HCl, exhibits unique physicochemical properties that make it indispensable in modern chemical synthesis and drug development pipelines.

The molecular structure of 2-Methylpropan-1-ammonium chloride features a central nitrogen atom bonded to three alkyl groups: two methyl groups and one isopropyl group, forming a tertiary amine core neutralized by hydrochloric acid. This configuration confers exceptional stability and reactivity under controlled conditions, enabling its use as both a synthetic intermediate and a functional moiety in advanced materials research. Recent studies published in Journal of Medicinal Chemistry highlight its role in stabilizing peptide-drug conjugates through electrostatic interactions, demonstrating its utility in targeted drug delivery systems.

In pharmaceutical applications, this compound serves as a critical building block for synthesizing bioactive molecules such as anticancer agents and neuroprotective compounds. A groundbreaking 2023 study from the University of Basel revealed that analogs incorporating this amine framework exhibit selective inhibition of histone deacetylase (HDAC) enzymes, offering new avenues for epigenetic therapy development. Its ability to form stable amides under mild conditions makes it particularly valuable for solid-phase peptide synthesis protocols.

Biochemical researchers increasingly utilize CAS 5041-09-8 compounds as buffering agents in cell culture media due to their pH-stabilizing properties within physiological ranges (pKa ~9). This application was validated in high-throughput screening platforms at the NIH, where consistent cell viability rates were maintained across multiple experimental cycles involving metabolomics profiling experiments.

The industrial sector leverages this compound's unique solubility profile—dissolving readily in polar solvents like ethanol and water—to produce specialty polymers with tailored amphiphilic characteristics. Innovations reported at the 2023 ACS National Meeting demonstrated its use as a co-monomer in creating stimuli-responsive hydrogels capable of reversible swelling under pH changes, promising applications in smart drug release systems.

Pioneering work by the MIT Chemical Engineering Lab has identified this compound's potential in asymmetric catalysis processes through chiral ligand design strategies published in Nature Catalysis. By incorporating this amine into transition metal complexes, researchers achieved enantioselectivities exceeding 95% during asymmetric hydrogenation reactions—a breakthrough for producing optically pure APIs required by regulatory guidelines.

Safety considerations emphasize proper storage practices given its hygroscopic nature and compatibility with oxidizing agents at elevated temperatures above 65°C. Current Good Manufacturing Practices (cGMP) guidelines recommend nitrogen-purged containers stored below 30°C to maintain purity levels critical for preclinical trials adhering to ICH Q7 standards.

Ongoing investigations into its role within CRISPR-based gene editing systems show promise for enhancing transfection efficiency when used as a co-delivery vector with lipid nanoparticles—a discovery recently highlighted at the European Society of Gene & Cell Therapy conference that could revolutionize gene therapy manufacturing protocols.

In material science applications, this compound's interaction with graphene oxide layers has enabled creation of conductive nanocomposites exhibiting tunable electrical properties reported in Acs Nano. These composites are now being evaluated for next-generation flexible electronics requiring stable performance across varying environmental conditions.

Epidemiological studies tracking occupational exposure data from chemical manufacturing facilities indicate negligible health risks when handled according to OSHA-recommended PPE protocols (Nitrile gloves + NIOSH-approved respirators). These findings align with toxicological assessments showing LD₅₀ values exceeding 3 g/kg in rodent models under OECD TG 423 testing frameworks.

Sustainable chemistry advancements have optimized its production via enzymatic catalysis pathways using lipase variants sourced from thermophilic bacteria—a method achieving >98% yield while reducing energy consumption by 40% compared to traditional alkylating processes documented in Greener Journal of Chemistry.

In diagnostic chemistry, conjugates formed between this amine and fluorescent dyes have enabled development of real-time PCR probes with sub-picomolar detection limits for SARS-CoV variants—a innovation recognized by the World Health Organization's Diagnostics Technical Advisory Group as critical for pandemic preparedness efforts.

Synergistic effects observed when combined with polyethylene glycol derivatives have led to novel surfactant formulations used in enhanced oil recovery operations meeting EPA environmental compliance standards while improving extraction efficiencies by up to 35% under reservoir simulation conditions reported at SPE Annual Technical Conference & Exhibition proceedings.

• 78-81-9(2-methylpropan-1-amine)
• 31044-82-3(2-(Aminomethyl)-2-methyl-1,3-propanediamine trihydrochloride)
• 556-53-6(1-Aminopropane Hydrochloride)
• 923560-91-2(1-Propanamine, 2-methyl-, magnesium salt (2:1))
• 2400-78-4(2-Methylpropane-1,3-diamine)
• 104810-31-3(n-propylamine-1-14c hydrochloride)
• 5813-64-9(2,2-Dimethylpropan-1-amine)
• 344298-88-0(n-Propyl-d7-amine HCl)
• 29082-53-9(1,3-Propanediamine,2,2-dimethyl-, hydrochloride (1:2))
• 15925-18-5(2,2-Dimethyl-1-propanamine hydrochloride)