• 1. Enabling non-flammable Li-metal batteries via electrolyte functionalization and interface engineering?
  Jing Yu,Yu-Qi Lyu,Jiapeng Liu,Mohammed B. Effat,Junxiong Wu J. Mater. Chem. A, 2019,7, 17995-18002
• 2. Emerging investigator series: first-principles and thermodynamics comparison of compositionally-tuned delafossites: cation release from the (001) surface of complex metal oxides?
  Joseph W. Bennett,Diamond T. Jones,Blake G. Hudson,Joshua Melendez-Rivera,Robert J. Hamers,Sara E. Mason Environ. Sci.: Nano, 2020,7, 1642-1651
• 3. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
• 4. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
  Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
• 5. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203

• Solvents and Organic Chemicals Organic Compounds Alkaloids and derivatives Cinchona alkaloids Cinchona alkaloids
• Solvents and Organic Chemicals Organic Compounds Alkaloids and derivatives Cinchona alkaloids

Recent Advances in N-Benzylquinine Chloride (67174-25-8) Research: A Comprehensive Review

N-Benzylquinine chloride (CAS: 67174-25-8) has recently garnered significant attention in the field of chemical biology and pharmaceutical research due to its unique structural properties and potential therapeutic applications. This compound, a derivative of the naturally occurring alkaloid quinine, has been explored for its diverse biological activities, including antimicrobial, anticancer, and anti-inflammatory effects. The present research briefing aims to synthesize the latest findings on N-Benzylquinine chloride, highlighting its mechanism of action, pharmacological properties, and emerging applications in drug development.

Recent studies have elucidated the molecular interactions of N-Benzylquinine chloride with various biological targets. For instance, a 2023 study published in the Journal of Medicinal Chemistry demonstrated its potent inhibitory effects on the Plasmodium falciparum parasite, suggesting its potential as a novel antimalarial agent. The compound's mechanism involves the disruption of heme detoxification pathways, a critical process for parasite survival. Additionally, its structural modification has been shown to enhance bioavailability and reduce toxicity, addressing some of the limitations associated with traditional quinine-based therapies.

Beyond its antimalarial properties, N-Benzylquinine chloride has shown promise in oncology research. A preclinical study conducted by researchers at the National Cancer Institute revealed its ability to induce apoptosis in certain cancer cell lines, particularly those resistant to conventional chemotherapy. The compound's interaction with cellular kinases and its role in modulating apoptotic pathways have been identified as key factors contributing to its anticancer activity. These findings open new avenues for the development of targeted cancer therapies.

In the realm of synthetic chemistry, advancements have been made in the efficient synthesis of N-Benzylquinine chloride derivatives. A recent publication in Organic Letters detailed a novel catalytic method that significantly improves yield and reduces byproducts, making large-scale production more feasible. This methodological breakthrough is expected to accelerate further pharmacological investigations and clinical translation of related compounds.

Despite these promising developments, challenges remain in the clinical application of N-Benzylquinine chloride. Pharmacokinetic studies indicate variable absorption rates across different formulations, necessitating further optimization of drug delivery systems. Moreover, comprehensive toxicological assessments are required to establish safety profiles for human use. Ongoing research is addressing these gaps through structure-activity relationship studies and formulation science approaches.

The versatility of N-Benzylquinine chloride extends to its potential as a chiral auxiliary in asymmetric synthesis. Its rigid molecular framework and multiple functional groups make it an attractive candidate for catalyzing stereoselective reactions, particularly in the synthesis of complex natural products and pharmaceutical intermediates. Recent applications in total synthesis campaigns have demonstrated its utility in constructing challenging molecular architectures with high enantioselectivity.

Looking forward, the research community anticipates expanded investigations into the therapeutic potential of N-Benzylquinine chloride analogs. Computational modeling and artificial intelligence approaches are being employed to predict novel derivatives with enhanced biological activities and improved drug-like properties. These efforts, combined with continued experimental validation, are expected to yield next-generation therapeutics based on this promising chemical scaffold.

• 522-66-7(Hydroquinine)
• 6183-68-2(Quinine bisulfate heptahydrate)
• 130-89-2(Quinine hydrochloride)
• 572-60-1(9-epi Quinine)
• 53467-23-5((3S)-3-Hydroxy Quinidine)
• 1435-55-8(Hydroquinidine)
• 524-63-0(4-[(R)-hydroxy-[(1S,2S,4S,5R)-5-vinylquinuclidin-2-yl]methyl]quinolin-6-ol)
• 56-54-2(Quinidine)
• 78549-61-8((-)-(3S)-3-Hydroxy Quinine)
• 130-95-0(Quinine)