Cas no 1435-55-8 (Hydroquinidine)
Hydroquinidine Chemical and Physical Properties
Names and Identifiers
-
- Hydroquinidine
- Dihydroquinine
- (8a,9R)-10,11-Dihydro-6'-methoxycinchonan-9-ol
- (5-Ethyl-1-azabicyclo[2.2.2]octan-7-yl)-(6-methoxyquinolin-4-yl)methanol
- hydroquinidine anhydrous
- (+)-Dihydroquinidine
- Dihydroquinidine
- (+)-Hydroquinidine
- (9S)-10,11-Dihydro-6'-methoxycinchonan-9-ol
- Hydroconquinine
- (9S)-10,11-Dihydro-6′-methoxycinchonan-9-ol
- Hydroqninidine
- Hydroconchinine
- Hydroxyquinidine
- 2-Hydroquinidine
- aluminum triacetate
- 10,11-Dihydroquinidine
- 8P68XPY4HG
- Dihydrochinidin
- HYDROQUININE
- (1S)-((2R,4S,5R)-5-Ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methanol
- LCN 834
- AK164414
- Hydroquinidine, 95%
- hydroquinidine hydrochloride
- Hydrochinin; Hydroquinine
- hydroquinidine HCl
- Hydrochinidin; Hydroquinidine
- NSC 757410
- EINECS 215-862-5
- Q5276449
- AKOS025146503
- 1435-55-8
- UNII-8P68XPY4HG
- (8R,9S)-10,11-Dihydro-6'-methoxy-9-cinchonanol
- ACon1_001481
- s4648
- NCGC00180461-02
- NCGC00385753-01
- Cinchonan-9-ol, 10,11-dihydro-6'-methoxy-, (9S)-
- s4658
- NS00004163
- SCHEMBL308961
- CHEMBL531472
- LJOQGZACKSYWCH-LHHVKLHASA-N
- (+)-Dihydroquinidine, analytical standard
- AS-16052
- MEGxp0_001892
- BRD-K98182306-001-01-3
- CCG-267773
- (S)-[(2R,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
- HYDROQUINIDINE [WHO-DD]
- (S)-((2R,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methanol
- MFCD00135599
- HYDROQUINIDINE [MI]
- NCGC00180461-01
- GNF-Pf-2067
- (S)-((1S,2R,4S,5R)-5-Ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methanol
- DTXSID50862110
- CCG-267774
- DB15300
- NS00080711
-
- MDL： MFCD29907227
- Inchi： 1S/C20H26N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h4-6,8,11,13-14,19-20,23H,3,7,9-10,12H2,1-2H3/t13-,14-,19+,20-/m0/s1
- InChI Key： LJOQGZACKSYWCH-LHHVKLHASA-N
- SMILES： O([H])[C@@]([H])(C1C([H])=C([H])N=C2C([H])=C([H])C(=C([H])C=12)OC([H])([H])[H])[C@@]1([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])N1C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[H]
Computed Properties
- Exact Mass: 326.19900
- Monoisotopic Mass: 326.199428076g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 24
- Rotatable Bond Count: 4
- Complexity: 432
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 3
- Undefined Atom Stereocenter Count : 1
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: Not determined
- XLogP3: 3.1
- Topological Polar Surface Area: 45.6
Experimental Properties
- Color/Form: Powder
- Density: 1.1117 (rough estimate)
- Melting Point: 169-170?°C (lit.)
- Boiling Point: 498.4°C at 760 mmHg
- Flash Point: 255.2±24.6 °C
- Refractive Index: 1.6800 (estimate)
- Solubility: chloroform: 0.1?g/mL, clear
- PSA: 45.59000
- LogP: 3.33510
- Merck: 13,4831
- Specific Rotation: 226 o (c=2 in EtOH)
- Optical Activity: [α]/D 232±4°, c =?2 in ethanol
- Solubility: 0.1?g/mL, clear
Hydroquinidine Security Information
-
Symbol:
- Signal Word：Warning
- Hazard Statement： H302,H312,H332
- Warning Statement： P280
- Hazardous Material transportation number：UN 1544
- WGK Germany：3
- Hazard Category Code： 20/21/22
- Safety Instruction： 36/37-36
- RTECS：MX3016000
-
Hazardous Material Identification：
- Safety Term：S36/37
- Risk Phrases：R20/21/22
- HazardClass：6.1(b)
- PackingGroup：III
- Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month
Hydroquinidine Customs Data
- HS CODE：2933990090
- Customs Data：
China Customs Code:
2933990090Overview:
2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Hydroquinidine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SU ZHOU XIN JIA YUAN HUA XUE Technology Co., Ltd. | lj0808-25g |
Hydroquinidine |
1435-55-8 | 98% | 25g |
￥2508.3 | 2024-07-19 | |
| SU ZHOU XIN JIA YUAN HUA XUE Technology Co., Ltd. | lj0808-5g |
Hydroquinidine |
1435-55-8 | 98% | 5g |
￥612.0 | 2024-07-19 | |
| MedChemExpress | HY-B0997-10mM*1mLinDMSO |
Hydroquinidine |
1435-55-8 | 99.54% | 10mM*1mLinDMSO |
￥550 | 2023-07-26 | |
| MedChemExpress | HY-B0997-100mg |
Hydroquinidine |
1435-55-8 | 99.97% | 100mg |
￥500 | 2024-04-20 | |
| S e l l e c k ZHONG GUO | S4658-100mg |
Hydroquinidine |
1435-55-8 | 99.59% | 100mg |
￥795.19 | 2023-09-15 | |
| S e l l e c k ZHONG GUO | S4658-500mg |
Hydroquinidine |
1435-55-8 | 99.59% | 500mg |
￥2432.46 | 2023-09-15 | |
| Chemenu | CM249420-10g |
Hydroquinidine |
1435-55-8 | 96% | 10g |
$149 | 2021-08-04 | |
| Chemenu | CM249420-25g |
Hydroquinidine |
1435-55-8 | 96% | 25g |
$252 | 2021-08-04 | |
| DC Chemicals | DC10227-100 mg |
Hydroquinidine |
1435-55-8 | >98% | 100mg |
$100.0 | 2022-02-28 | |
| DC Chemicals | DC10227-250 mg |
Hydroquinidine |
1435-55-8 | >98% | 250mg |
$200.0 | 2022-02-28 |
Hydroquinidine Suppliers
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Hydroquinidine Related Literature
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Govind Reddy Mol. Syst. Des. Eng., 2021,6, 779-789
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Juan J. Sánchez,Miguel López-Haro,Juan C. Hernández-Garrido,Ginesa Blanco,Miguel A. Cauqui,José M. Rodríguez-Izquierdo,José A. Pérez-Omil,José J. Calvino,María P. Yeste J. Mater. Chem. A, 2019,7, 8993-9003
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Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
-
Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
Additional information on Hydroquinidine
Comprehensive Guide to Hydroquinidine (CAS No. 1435-55-8): Properties, Applications, and Research Insights
Hydroquinidine (CAS No. 1435-55-8), a stereoisomer of quinidine, is a naturally occurring alkaloid derived from the bark of Cinchona trees. This compound has garnered significant attention in pharmaceutical and chemical research due to its unique chiral properties and potential therapeutic applications. With the rise of AI-driven drug discovery and green chemistry trends, researchers are increasingly exploring Hydroquinidine as a versatile building block for asymmetric synthesis and bioactive molecule development.
The molecular structure of Hydroquinidine features a quinoline core with hydroxyl and methoxy functional groups, contributing to its distinct physicochemical properties. Its chiral resolution capabilities make it invaluable in the production of enantiomerically pure compounds, a critical requirement in modern pharmaceutical manufacturing. Recent studies published in journals like the Journal of Medicinal Chemistry highlight its role in developing novel cardiac arrhythmia treatments, aligning with growing public interest in heart health supplements and natural-derived medicines.
In analytical chemistry, Hydroquinidine serves as a reference standard for HPLC method development and chiral separations. Laboratories worldwide utilize its well-characterized properties to validate analytical methods, particularly in quality control for botanical extracts and alkaloid-containing products. The compound's UV absorption characteristics (λmax ~ 250 nm and 330 nm) make it particularly suitable for spectrophotometric analysis techniques that are frequently searched by analytical chemists.
Current research trends show increasing interest in Hydroquinidine derivatives for their potential anti-malarial properties, connecting to global health discussions about tropical disease prevention. Unlike its better-known relative quinine, Hydroquinidine exhibits different pharmacokinetic profiles that may offer advantages in specific therapeutic applications. Patent databases reveal ongoing investigations into its use as a catalyst ligand in organocatalysis, particularly for carbon-carbon bond forming reactions that are fundamental to sustainable chemistry practices.
The safety profile of Hydroquinidine has been extensively documented in REACH compliance studies, showing favorable environmental and handling characteristics compared to synthetic alternatives. This positions the compound favorably within the green chemistry movement that dominates current chemical industry discourse. Material safety data sheets emphasize standard laboratory precautions for alkaloid handling, with no special restrictions beyond typical laboratory safety protocols.
From a commercial perspective, Hydroquinidine availability remains stable with global suppliers offering various purity grades (98%-99.5%) to meet different application needs. The compound's price stability and reliable supply chain make it attractive for pharmaceutical development projects, especially those exploring natural product derivatives. Quality specifications typically include tests for optical rotation and residual solvent content, parameters frequently queried by quality assurance professionals.
Emerging applications in material science have expanded the utility of Hydroquinidine beyond traditional medicinal chemistry. Recent conference presentations describe its incorporation into chiral stationary phases for advanced chromatography systems, addressing the analytical chemistry community's growing need for high-resolution separation technologies. These developments align with search trends showing increased interest in purification techniques for complex natural product mixtures.
Storage and handling recommendations for Hydroquinidine emphasize protection from light and moisture, with optimal stability achieved at 2-8°C under inert atmosphere. These conditions mirror best practices for alkaloid preservation that are commonly searched by laboratory managers and compound archivists. The compound's relatively long shelf life (typically 3+ years when properly stored) contributes to its popularity as a research chemical with reliable performance characteristics.
Future research directions for Hydroquinidine may explore its potential in neurological applications, building on preliminary studies suggesting activity at certain ion channels. This connects to widespread public interest in cognitive health and neuroprotective compounds. Additionally, its role in asymmetric synthesis continues to evolve, particularly in the development of chiral catalysts for environmentally friendly chemical processes—a hot topic in both academic and industrial chemistry circles.
