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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzenesulfonamides

Professional Introduction to 3-(aminomethyl)benzene-1-sulfonamide hydrochloride (CAS No. 670280-13-4)

3-(aminomethyl)benzene-1-sulfonamide hydrochloride, identified by the Chemical Abstracts Service Number (CAS No.) 670280-13-4, is a significant compound in the field of pharmaceutical chemistry and medicinal research. This compound belongs to the class of sulfonamides, which are well-known for their broad spectrum of biological activities and have been extensively studied for their potential therapeutic applications. The structural features of 3-(aminomethyl)benzene-1-sulfonamide hydrochloride, particularly the presence of both an aminomethyl group and a sulfonamide moiety, contribute to its unique chemical properties and make it a valuable scaffold for drug discovery and development.

The sulfonamide functional group is characterized by a sulfur atom double-bonded to an oxygen atom and single-bonded to two other oxygen atoms, which are further connected to a nitrogen atom. This arrangement creates a highly polar and reactive site that can interact with various biological targets, including enzymes and receptors. In the case of 3-(aminomethyl)benzene-1-sulfonamide hydrochloride, the additional presence of an aminomethyl group enhances its versatility, allowing for further derivatization and functionalization to tailor its pharmacological properties.

Recent advancements in medicinal chemistry have highlighted the importance of sulfonamides in the development of novel therapeutic agents. The aminomethyl substituent in 3-(aminomethyl)benzene-1-sulfonamide hydrochloride provides a site for hydrogen bonding interactions, which can be crucial for binding affinity and selectivity when designing small-molecule drugs. This feature has been leveraged in the development of compounds targeting various diseases, including infectious diseases, cancer, and inflammatory disorders.

One of the most compelling aspects of 3-(aminomethyl)benzene-1-sulfonamide hydrochloride is its potential as a lead compound for further optimization. Researchers have utilized computational methods, such as molecular docking and virtual screening, to identify derivatives with enhanced potency and reduced toxicity. These studies have demonstrated that modifications to the aromatic ring or the sulfonamide moiety can significantly alter the biological activity of the compound. For instance, studies have shown that introducing additional polar or charged groups can improve solubility and cell membrane permeability, making it more suitable for oral administration.

The pharmaceutical industry has shown particular interest in sulfonamides due to their historical success in treating bacterial infections. While modern antibiotics have largely replaced sulfonamides for this purpose, they remain valuable in other therapeutic areas. For example, sulfonamides have been explored as inhibitors of carbonic anhydrase, an enzyme involved in various physiological processes, including acid-base balance and tumor growth. The structural motif of 3-(aminomethyl)benzene-1-sulfonamide hydrochloride aligns well with this target class, making it a promising candidate for further investigation.

In addition to its potential as an anti-inflammatory agent or carbonic anhydrase inhibitor, 3-(aminomethyl)benzene-1-sulfonamide hydrochloride has also been investigated for its role in modulating immune responses. Sulfonamides can interact with various immune cells and signaling pathways, making them useful in developing immunomodulatory therapies. Recent research has focused on leveraging these interactions to treat autoimmune diseases or enhance vaccine efficacy. The hydrochloride salt form of this compound improves its stability and bioavailability, which are critical factors for clinical translation.

The synthesis of 3-(aminomethyl)benzene-1-sulfonamide hydrochloride involves multi-step organic reactions that require careful optimization to ensure high yield and purity. Common synthetic routes include nucleophilic substitution reactions on benzene derivatives followed by functional group transformations to introduce the sulfonamide moiety. Advances in synthetic methodologies have enabled more efficient and scalable production processes, which are essential for industrial applications.

From a regulatory perspective, compounds like 3-(aminomethyl)benzene-1-sulfonamide hydrochloride must undergo rigorous testing to demonstrate safety and efficacy before they can be approved for clinical use. This includes preclinical studies using cell culture models and animal models to assess toxicity, pharmacokinetics, and pharmacodynamics. Regulatory agencies such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) provide guidelines that ensure these compounds meet stringent quality standards.

The future prospects for 3-(aminomethyl)benzene-1-sulfonamide hydrochloride are promising, with ongoing research exploring new therapeutic applications and improving existing ones. Innovations in drug delivery systems, such as nanoparticles or prodrugs, could enhance the therapeutic index of this compound by improving bioavailability or targeting specificity. Additionally, collaborations between academia and industry are fostering interdisciplinary approaches that could accelerate the discovery and development of novel sulfonamide-based drugs.

In conclusion,3-(aminomethyl)benzene-1-sulfonamide hydrochloride (CAS No. 670280-13-4) is a versatile compound with significant potential in pharmaceutical research. Its unique structural features make it a valuable scaffold for drug discovery, with applications ranging from infectious diseases to cancer therapy. As research continues to uncover new biological targets and synthetic strategies,3-(aminomethyl)benzene-1-sulfonamide hydrochloride is poised to play an important role in shaping the future of medicinal chemistry.

• 65625-49-2(3,5-dimethylbenzene-1-sulfonamide)
• 60758-21-6(Benzenesulfonamide,4-(aminomethyl)-, sodium salt (1:1))
• 138-37-4(4-(Aminomethyl)benzenesulfonamide hydrochloride)
• 918810-53-4(1,3-Benzenedisulfonamide, 5-(aminomethyl)-)
• 138-39-6(4-Aminomethylbenzenesulfonamide)
• 1899-94-1(3-Methylbenzenesulfonamide)
• 21481-58-3(Benzenemethanaminium,4-(aminosulfonyl)-N,N,N-trimethyl-)
• 65195-43-9(Benzenesulfonamide,4-(aminomethyl)-, hydrochloride, hydrate (3:3:2))
• 628298-58-8(3-Sulfamoylbenzylamine)
• 736913-57-8(3-(1-aminoethyl)benzene-1-sulfonamide)