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Comprehensive Overview of 3-Sulfamoylbenzylamine (CAS No. 628298-58-8): Properties, Applications, and Industry Insights

3-Sulfamoylbenzylamine (CAS No. 628298-58-8) is a specialized organic compound gaining attention in pharmaceutical and chemical research due to its unique sulfonamide-functionalized structure. As a derivative of benzylamine, this compound features a sulfamoyl group at the meta position, which enhances its reactivity and potential applications in drug discovery and material science. Researchers and industry professionals are increasingly exploring its role as a building block for bioactive molecules, particularly in the development of enzyme inhibitors and receptor modulators.

The growing interest in sulfonamide-containing compounds like 3-Sulfamoylbenzylamine aligns with current trends in targeted drug design and small-molecule therapeutics. Recent PubMed and Google Scholar data reveal rising searches for "sulfamoyl group applications" and "benzylamine derivatives in medicine," reflecting its relevance in modern research. The compound's molecular structure (C₇H₁₀N₂O₂S) allows for diverse chemical modifications, making it valuable for creating libraries of pharmacologically active compounds.

From a synthetic chemistry perspective, 3-Sulfamoylbenzylamine demonstrates excellent solubility in polar solvents like DMSO and methanol, a property critical for high-throughput screening applications. Analytical studies using HPLC and NMR spectroscopy confirm its high purity (>98%) in commercial samples, meeting the stringent requirements of medicinal chemistry projects. The compound's stability under physiological pH conditions further enhances its utility in biological assays and drug metabolism studies.

Industry reports highlight the expanding market for sulfonamide intermediates, with 3-Sulfamoylbenzylamine positioned as a key material for antibacterial agents and carbonic anhydrase inhibitors. Its structural similarity to approved drugs like acetazolamide has spurred investigations into repurposing strategies – a hot topic in computational chemistry circles. Patent databases show increasing filings incorporating this scaffold for neurological disorders and metabolic disease targets.

Environmental and safety profiles of 3-Sulfamoylbenzylamine comply with REACH regulations, with biodegradation studies indicating moderate environmental persistence. Proper handling requires standard laboratory precautions, including PPE and ventilation, as recommended in SDS documentation. The compound's low ecotoxicity compared to halogenated analogs contributes to its preference in green chemistry initiatives.

Emerging applications in material science utilize 3-Sulfamoylbenzylamine as a precursor for functionalized polymers with enhanced thermal stability. Recent ACS publications describe its incorporation into ion-exchange membranes for fuel cells – addressing the global demand for clean energy technologies. This multidisciplinary utility positions the compound at the intersection of pharmaceutical innovation and advanced materials development.

Quality control protocols for 3-Sulfamoylbenzylamine emphasize chromatographic purity assessments and residual solvent monitoring, particularly for GMP-grade material. Analytical method development for this compound frequently appears in QC/QA forums, reflecting industry needs for standardized characterization techniques. Storage recommendations typically suggest 2-8°C under inert atmosphere to maintain long-term stability.

The global supply chain for 3-Sulfamoylbenzylamine shows increasing regional diversification, with manufacturers adopting continuous flow chemistry to improve yield and reduce waste. Market intelligence suggests growing demand from contract research organizations and academic institutions engaged in fragment-based drug discovery. Pricing trends indicate moderate stability, with bulk procurement offering cost advantages for large-scale structure-activity relationship studies.

Future research directions for 3-Sulfamoylbenzylamine derivatives may explore their potential in PROTAC technology and covalent inhibitors, two rapidly advancing areas in drug development. The compound's balanced lipophilicity (LogP ~0.8) and hydrogen bonding capacity make it particularly suitable for these applications. Collaborative studies between computational chemists and synthetic biologists may unlock novel applications in precision medicine platforms.

• 196107-64-9(3-propylbenzene-1-sulfonamide)
• 60758-21-6(Benzenesulfonamide,4-(aminomethyl)-, sodium salt (1:1))
• 70-55-3(4-methylbenzene-1-sulfonamide)
• 138-37-4(4-(Aminomethyl)benzenesulfonamide hydrochloride)
• 138-39-6(4-Aminomethylbenzenesulfonamide)
• 287476-18-0(Benzenesulfonamide-15N,4-methyl-)
• 1899-94-1(3-Methylbenzenesulfonamide)
• 21481-58-3(Benzenemethanaminium,4-(aminosulfonyl)-N,N,N-trimethyl-)
• 65195-43-9(Benzenesulfonamide,4-(aminomethyl)-, hydrochloride, hydrate (3:3:2))
• 736913-57-8(3-(1-aminoethyl)benzene-1-sulfonamide)