Cas no 62400-75-3 (5-(Hydroxymethyl)pyrrolidin-2-one)

5-(Hydroxymethyl)pyrrolidin-2-one is a versatile heterocyclic compound featuring both a hydroxymethyl group and a lactam moiety, making it a valuable intermediate in organic synthesis and pharmaceutical applications. Its structure allows for further functionalization, enabling the production of derivatives with tailored properties. The compound exhibits good solubility in polar solvents, facilitating its use in various reaction conditions. Its stability under standard conditions ensures reliable handling and storage. Potential applications include its role as a building block for bioactive molecules, polymers, and specialty chemicals. The hydroxymethyl group enhances reactivity, offering opportunities for selective modifications in synthetic pathways. This compound is particularly useful in medicinal chemistry for the development of novel pharmacophores.
5-(Hydroxymethyl)pyrrolidin-2-one structure
62400-75-3 structure
Product Name:5-(Hydroxymethyl)pyrrolidin-2-one
CAS No:62400-75-3
MF:C5H9NO2
MW:115.130461454391
MDL:MFCD06661931
CID:501941
PubChem ID:558359
Update Time:2025-06-08

5-(Hydroxymethyl)pyrrolidin-2-one Chemical and Physical Properties

Names and Identifiers

    • 5-(Hydroxymethyl)pyrrolidin-2-one
    • 2-Pyrrolidinone,5-(hydroxymethyl)-
    • 5-hydroxymethyl-pyrrolidine-2-one
    • (+/-)-pyroglutaminol
    • (5S)-5-(hydroxymethyl)tetrahydro-1H-2-pyrrolone
    • 5(S)-hydroxymethyl-2-pyrrolidinone
    • 5-hydroxymethyl-2-pyrrolidone
    • 5-Hydroxymethylpyrrolidin-2-one
    • 5-Hydroxymethyl-pyrrolidin-2-one
    • ACMC-209e6n
    • ACMC-209nw3
    • ACMC-20am31
    • PubChem21689
    • pyroglutaminol
    • 5-(Hydroxymethyl)-2-pyrrolidinone
    • 2-Pyrrolidinone, 5-(hydroxymethyl)-
    • HOBJEFOCIRXQKH-UHFFFAOYSA-N
    • (s)-pyroglutaminol
    • Pyrrolid-2-one-5-methanol
    • 5-hydroxymethyl-2-pyrrolidinone
    • 5-(Hydroxymethyl)-2-pyr
    • SY004164
    • Z235344363
    • 62400-75-3
    • MFCD06661931
    • SCHEMBL210598
    • CS-W001608
    • FT-0605332
    • EN300-34849
    • AB02985
    • F9995-1007
    • 5-(Hydroxymethyl)-2-pyrrolidinone #
    • PB47496
    • FT-0660911
    • AB00988443-01
    • J-516357
    • DTXSID10339752
    • (r)-(-)-5-hydroxymethyl-2-pyrrolidinone
    • FT-0605061
    • 10.14272/HOBJEFOCIRXQKH-UHFFFAOYSA-N
    • doi:10.14272/HOBJEFOCIRXQKH-UHFFFAOYSA-N
    • AKOS016843843
    • AKOS001372449
    • A868480
    • SY004165
    • SY059670
    • DS-6373
    • DB-011645
    • DB-073113
    • MDL： MFCD06661931
    • Inchi： 1S/C5H9NO2/c7-3-4-1-2-5(8)6-4/h4,7H,1-3H2,(H,6,8)
    • InChI Key： HOBJEFOCIRXQKH-UHFFFAOYSA-N
    • SMILES： OCC1CCC(N1)=O

Computed Properties

  • Exact Mass: 115.06337
  • Monoisotopic Mass: 115.063328530g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 8
  • Rotatable Bond Count: 1
  • Complexity: 103
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: -1
  • Topological Polar Surface Area: 49.3

Experimental Properties

  • Density: 1.153
  • Boiling Point: 346.0±15.0℃ at 760 mmHg
  • Flash Point: 163 °C
  • PSA: 49.33

5-(Hydroxymethyl)pyrrolidin-2-one Pricemore >>

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5-(Hydroxymethyl)pyrrolidin-2-one Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Hydrogen ,  Phosphoric acid Catalysts: Rhodium ,  Molybdenum oxide Solvents: Water ;  6 h, pH 1.8, 70 bar, 100 °C
Reference
Rh-Catalyzed Hydrogenation of Amino Acids to Biobased Amino Alcohols: Tackling Challenging Substrates and Application to Protein Hydrolysates
Vandekerkhove, Annelies ; Claes, Laurens ; De Schouwer, Free; Van Goethem, Cedric ; Vankelecom, Ivo F. J.; et al, ACS Sustainable Chemistry & Engineering, 2018, 6(7), 9218-9228

5-(Hydroxymethyl)pyrrolidin-2-one Raw materials

5-(Hydroxymethyl)pyrrolidin-2-one Preparation Products

5-(Hydroxymethyl)pyrrolidin-2-one Suppliers

Amadis Chemical Company Limited
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Audited Supplier Audited Supplier
(CAS:62400-75-3)5-(Hydroxymethyl)pyrrolidin-2-one
Order Number:A868480
Stock Status:in Stock
Quantity:25g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 09:12
Price ($):289.0

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Amadis Chemical Company Limited
(CAS:62400-75-3)5-(Hydroxymethyl)pyrrolidin-2-one
A868480
Purity:99%
Quantity:25g
Price ($):289.0
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