Production Method 1

56-86-0

533-88-0

498-63-5

63493-28-7

62400-75-3

98-79-3

40217-11-6

927-55-9

16369-14-5

21926-01-2

Reaction Conditions

1.1 Reagents: Hydrogen ,  Phosphoric acid Catalysts: Rhodium ,  Molybdenum oxide Solvents: Water ;  6 h, pH 1.8, 70 bar, 100 °C

Reference

Rh-Catalyzed Hydrogenation of Amino Acids to Biobased Amino Alcohols: Tackling Challenging Substrates and Application to Protein Hydrolysates

Vandekerkhove, Annelies ; Claes, Laurens ; De Schouwer, Free; Van Goethem, Cedric ; Vankelecom, Ivo F. J.; et al, ACS Sustainable Chemistry & Engineering, 2018, 6(7), 9218-9228

2-Amino-5-hydroxypentanoic acid Raw materials

• L-Glutamic acid

2-Amino-5-hydroxypentanoic acid Preparation Products

• (pyrrolidin-2-yl)methanol (498-63-5)
• pentan-2-amine (63493-28-7)
• 5-(Hydroxymethyl)pyrrolidin-2-one (62400-75-3)
• L-Pyroglutamic acid (98-79-3)
• 4-amino-5-hydroxypentanoic acid (40217-11-6)
• 4-Amino-1-pentanol (927-55-9)
• DL-2-Amino-1-pentanol (16369-14-5)
• 2-aminopentane-1,5-diol (21926-01-2)
• 2-Amino-5-hydroxypentanoic acid (533-88-0)

• 1. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 2. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210
• 3. An approach to C–N activation: coupling of arenesulfonyl hydrazides and arenesulfonyl chlorides with tert-amines via a metal-, oxidant- and halogen-free anodic oxidation??
  M. Sheykhan,S. Khani,S. Shaabanzadeh,M. Joafshan Green Chem., 2017,19, 5940-5948
• 4. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
• 5. An alkynylboronatecycloaddition strategy to functionalised benzyne derivatives?
  James D. Kirkham,Patrick M. Delaney,George J. Ellames,Eleanor C. Row,Joseph P. A. Harrity Chem. Commun., 2010,46, 5154-5156

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Alpha amino acids

Introduction to 2-Amino-5-hydroxypentanoic acid (CAS No. 533-88-0)

2-Amino-5-hydroxypentanoic acid, identified by the Chemical Abstracts Service Number (CAS No.) 533-88-0, is a significant compound in the field of biochemistry and pharmaceutical research. This amino acid derivative has garnered attention due to its unique structural properties and potential applications in drug development, enzyme inhibition, and metabolic studies. The compound features both an amino group and a hydroxyl group on a five-carbon chain, making it a versatile building block for synthesizing more complex molecules.

The molecular structure of 2-Amino-5-hydroxypentanoic acid contributes to its reactivity and functionality. The presence of both functional groups allows it to participate in various chemical reactions, including peptide bond formation, chelation, and redox processes. These characteristics make it a valuable intermediate in organic synthesis and a candidate for developing novel therapeutic agents.

In recent years, research on 2-Amino-5-hydroxypentanoic acid has been expanding, particularly in the context of its role in biological systems. Studies have explored its potential as a precursor for neurotransmitter analogs and as a component in enzyme inhibitors. For instance, modifications of this compound have been investigated for their ability to modulate the activity of certain enzymes involved in metabolic pathways. This has opened up new avenues for treating metabolic disorders and inflammatory conditions.

One of the most intriguing aspects of 2-Amino-5-hydroxypentanoic acid is its potential application in peptide mimetics. Peptide mimetics are designed to mimic the biological activity of natural peptides but with improved stability and pharmacokinetic properties. The structural features of 2-Amino-5-hydroxypentanoic acid make it an ideal candidate for such applications, as it can be incorporated into peptide chains to enhance their binding affinity and specificity. This has implications for the development of targeted therapies in oncology and immunology.

The pharmaceutical industry has also shown interest in 2-Amino-5-hydroxypentanoic acid due to its potential as a scaffold for drug discovery. By modifying its structure, researchers can generate libraries of compounds with varying biological activities. High-throughput screening techniques combined with computational modeling have accelerated the process of identifying lead compounds for further development. This approach has led to several promising candidates that are currently undergoing preclinical studies.

Another area where 2-Amino-5-hydroxypentanoic acid has found utility is in the field of materials science. Its ability to form stable complexes with metal ions makes it useful in developing metal-organic frameworks (MOFs) and coordination polymers. These materials have applications in catalysis, gas storage, and separation technologies. The versatility of 2-Amino-5-hydroxypentanoic acid as a ligand has opened up new possibilities for designing functional materials with tailored properties.

The synthesis of 2-Amino-5-hydroxypentanoic acid has also been optimized to meet the demands of industrial-scale production. Various synthetic routes have been developed, including enzymatic synthesis and solid-phase peptide synthesis (SPPS). These methods ensure high yield and purity, which are critical for pharmaceutical applications. Advances in synthetic chemistry have made it possible to produce large quantities of this compound efficiently.

In conclusion, 2-Amino-5-hydroxypentanoic acid (CAS No. 533-88-0) is a multifaceted compound with significant potential in biochemistry, pharmaceuticals, and materials science. Its unique structural features and reactivity make it a valuable tool for researchers working on drug development, enzyme inhibition, and metabolic studies. As research continues to uncover new applications for this compound, its importance is likely to grow further.

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