Production Method 1

380883-31-8

588-43-2

871-22-7

Reaction Conditions

1.1 Reagents: Benzoyl peroxide Solvents: Cyclohexane

Reference

Preparation of 1-phenylcyclohexa-2,5-diene-1-carboxylates and their use in free-radical mediated syntheses

Baguley, Paul A.; et al, Journal of the Chemical Society, 2002, (3), 304-309

Production Method 2

4794-05-2

588-43-2

871-22-7

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran
1.2 -
1.3 Reagents: Hydrochloric acid Solvents: Water
2.1 Reagents: Benzoyl peroxide Solvents: Cyclohexane

Reference

Preparation of 1-phenylcyclohexa-2,5-diene-1-carboxylates and their use in free-radical mediated syntheses

Baguley, Paul A.; et al, Journal of the Chemical Society, 2002, (3), 304-309

tributyl orthoformate Raw materials

• Cyclohexa-2,5-dien-1-ylbenzene
• 2,5-Cyclohexadiene-1-carboxylic acid, 1-phenyl-

tributyl orthoformate Preparation Products

• tributyl orthoformate (588-43-2)
• 1,1'-Ethylidenebis(oxy)bisbutane (871-22-7)

• 1. Synthesis of squaraine dyes under mild conditions: applications for labelling and sensing of biomolecules
  Mazen Haj Sleiman,Sylvain Ladame Chem. Commun. 2014 50 5288
• 2. Advances in synthesis and application of near-infrared absorbing squaraine dyes
  Lei Hu,Zhengquan Yan,Hongyao Xu RSC Adv. 2013 3 7667
• 3. A new approach to symmetrical and unsymmetrical photoconductive squaraines
  Kock-Yee Law,F. Court Bailey J. Chem. Soc. Chem. Commun. 1991 1156
• 4. Influence of aprotic solvents on the O–D stretching band of methan[2H]ol
  Alan G. Burden,Geoffrey Collier,John Shorter J. Chem. Soc. Perkin Trans. 2 1976 1627
• 5. Near IR sensitive unsymmetrical squaraines
  Kock-Yee Law,F. Court Bailey J. Chem. Soc. Chem. Commun. 1990 863

Recent Advances in the Application of Tributyl Orthoformate (588-43-2) in Chemical and Pharmaceutical Research

In recent years, tributyl orthoformate (CAS: 588-43-2) has emerged as a versatile reagent in chemical synthesis and pharmaceutical research. This compound, known for its role as a protecting group and formylation agent, has been increasingly utilized in the development of novel drug candidates and bioactive molecules. The latest studies highlight its significance in facilitating complex organic transformations, particularly in the synthesis of heterocyclic compounds and peptide derivatives.

A recent study published in the Journal of Medicinal Chemistry demonstrated the efficacy of tributyl orthoformate in the synthesis of antiviral agents. Researchers employed this reagent as a key intermediate in the preparation of nucleoside analogs, which showed promising activity against RNA viruses. The study underscored the reagent's ability to enhance yield and purity in multi-step synthetic pathways, making it a valuable tool for pharmaceutical development.

Another significant application of tributyl orthoformate was reported in the field of peptide chemistry. A 2023 paper in Organic Letters detailed its use in the formylation of N-terminal amino acids, a critical step in the synthesis of peptide-based therapeutics. The researchers noted that tributyl orthoformate offered superior selectivity and milder reaction conditions compared to traditional formylation reagents, reducing side reactions and improving overall efficiency.

Beyond its synthetic applications, tributyl orthoformate has also been investigated for its potential in drug delivery systems. A recent patent application described its incorporation into lipid nanoparticles for the targeted delivery of small-molecule drugs. The unique chemical properties of tributyl orthoformate were found to enhance the stability and bioavailability of the encapsulated compounds, opening new avenues for formulation development.

In conclusion, the growing body of research on tributyl orthoformate (588-43-2) underscores its importance in modern chemical and pharmaceutical research. Its versatility as a reagent, coupled with its favorable physicochemical properties, makes it an indispensable tool for scientists working on drug discovery and development. Future studies are expected to further explore its applications in emerging areas such as bioconjugation and prodrug design.

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