Synthesis of squaraine dyes under mild conditions: applications for labelling and sensing of biomolecules?

Chemical Communications Pub Date: 2013-12-18 DOI: 10.1039/C3CC47894G

Abstract

We report the synthesis of squaraine dyes under mild conditions by carbodiimide activation of squaric acid or semi-squaraine dyes. Despite low yields when the reaction was carried out in solution, these conditions were successfully applied to efficient peptide labelling on resin and nucleic acid sensing in solution.

Graphical abstract: Synthesis of squaraine dyes under mild conditions: applications for labelling and sensing of biomolecules
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