• 1. An astrophysically-relevant mechanism for amino acid enantiomer enrichment
  Stephen P. Fletcher,Richard B. C. Jagt,Ben L. Feringa Chem. Commun., 2007, 2578-2580
• 2. An atomic scale study of defects in Co2FeAl
  Ravi Kumar Yadav,R. Govindaraj Phys. Chem. Chem. Phys., 2020,22, 26876-26886
• 3. An artificial photosynthetic system for photoaccumulation of two electrons on a fused dipyridophenazine (dppz)–pyridoquinolinone ligand?
  Philipp Traber,Stephan Kupfer,Stefanie Gr?fe,Isabelle Baussanne,Martine Demeunynck,Jean-Marie Mouesca,Serge Gambarelli,Vincent Artero,Murielle Chavarot-Kerlidou Chem. Sci., 2018,9, 4152-4159
• 4. An alternative biorefinery approach to address microalgal seasonality: blending with spent coffee grounds
  Andre Prates Pereira,Tao Dong,Eric P. Knoshaug,Nick Nagle,Ryan Spiller,Bonnie Panczak,Christopher J. Chuck,Philip T. Pienkos Sustainable Energy Fuels, 2020,4, 3400-3408
• 5. An integrated chip for immunofluorescence and its application to analyze lysosomal storage disorders
  Jie Shen,Ying Zhou,Tu Lu,Junya Peng,Zhixiang Lin,Yuhong Pang,Li Yu Lab Chip, 2012,12, 317-324

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylacetamides

Professional Introduction to 2-(4-Methylphenyl)acetohydrazide (CAS No. 57676-54-7)

2-(4-Methylphenyl)acetohydrazide, chemically designated as 2-(p-tolyl)acetohydrazide, is a significant compound in the field of pharmaceutical chemistry and biochemical research. With a CAS number of 57676-54-7, this molecule has garnered attention due to its versatile applications in synthetic chemistry and potential therapeutic uses. This introduction aims to provide a comprehensive overview of the compound, its properties, and its relevance in contemporary research.

The molecular structure of 2-(4-Methylphenyl)acetohydrazide consists of a phenyl ring substituted with a methyl group at the para position and an acetohydrazide functional group attached to the other side. This structural arrangement imparts unique chemical reactivity, making it a valuable intermediate in organic synthesis. The presence of the acetohydrazide moiety allows for further functionalization, enabling the development of more complex molecules.

In recent years, 2-(4-Methylphenyl)acetohydrazide has been explored for its potential in drug discovery and development. Its ability to act as a precursor in the synthesis of heterocyclic compounds has made it particularly interesting for medicinal chemists. Researchers have leveraged its reactivity to create novel scaffolds that exhibit various biological activities. For instance, derivatives of this compound have shown promise in inhibiting specific enzymatic pathways associated with inflammatory diseases and cancer.

One of the most compelling aspects of 2-(4-Methylphenyl)acetohydrazide is its role in the synthesis of biologically active molecules. The phenyl ring and the acetohydrazide group provide multiple sites for chemical modification, allowing for the creation of libraries of compounds with tailored properties. This flexibility has been exploited in high-throughput screening campaigns to identify lead compounds for further optimization.

Recent studies have highlighted the compound's utility in developing small-molecule inhibitors targeting protein-protein interactions. These interactions are often critical in cellular signaling pathways and are implicated in numerous diseases. By designing molecules that disrupt these interactions, researchers aim to develop treatments that modulate disease processes at a molecular level. The structural features of 2-(4-Methylphenyl)acetohydrazide make it an ideal candidate for such applications.

The synthesis of 2-(4-Methylphenyl)acetohydrazide typically involves multi-step organic reactions, starting from readily available precursors such as p-tolualdehyde and hydrazine hydrate. The reaction sequence often includes condensation steps followed by purification to obtain high yields of the desired product. Advances in synthetic methodologies have improved the efficiency and scalability of these processes, making it more feasible to produce larger quantities for research and industrial purposes.

In addition to its pharmaceutical applications, 2-(4-Methylphenyl)acetohydrazide has found utility in materials science and chemical biology. Its ability to form coordination complexes with metal ions has been explored for developing catalysts and sensors. These complexes exhibit unique electronic properties that can be harnessed for various technological applications.

The compound's stability under different conditions is another area of interest. Studies have investigated its behavior under thermal and photochemical stress, providing insights into its potential degradation pathways. Understanding these properties is crucial for optimizing storage conditions and ensuring consistency in experimental results.

Ethical considerations are also important when working with compounds like 2-(4-Methylphenyl)acetohydrazide. While it does not fall under categories of hazardous or controlled substances, proper handling procedures must be followed to ensure safety in laboratory settings. This includes using appropriate personal protective equipment and working in well-ventilated areas.

The future prospects for 2-(4-Methylphenyl)acetohydrazide are promising, with ongoing research exploring new synthetic routes and applications. Collaborative efforts between academia and industry are likely to drive innovation, leading to novel therapeutic agents and advanced materials based on this versatile compound.

• 793-25-9(1,2-diacetyl-1,2-diphenylhydrazine)
• 82122-73-4(Benzeneacetic acid, 2-acetylhydrazide)
• 57676-53-6(m-Tolyl-acetic Acid Hydrazide)
• 937-39-3(2-Phenylacetohydrazide)
• 34800-90-3(1-Naphthaleneacethydrazide)
• 139277-58-0(2-(Biphenyl-4-yl)acetohydrazide)
• 25095-39-0(1-Naphthaleneaceticacid, 7-methyl-, hydrazide)
• 20277-02-5(2-(4-Hydroxyphenyl)acetohydrazide)
• 1199-86-6(Benzeneacetic acid,2-methylhydrazide)
• 6636-02-8(2,2-Diphenylacetohydrazide)