Cas no 5585-33-1 (2-(morpholin-4-yl)aniline)

2-(Morpholin-4-yl)aniline is a versatile aromatic amine derivative featuring a morpholine substituent at the 2-position of the aniline ring. This compound is valued for its dual functionality, combining the reactivity of an aniline group with the structural influence of the morpholine moiety. It serves as a key intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and specialty chemicals. The morpholine ring enhances solubility and stability, while the aniline group enables further functionalization through reactions such as diazotization, acylation, or coupling. Its well-defined structure and consistent purity make it a reliable building block for researchers and industrial applications requiring precise molecular modifications.
2-(morpholin-4-yl)aniline structure
2-(morpholin-4-yl)aniline structure
Product Name:2-(morpholin-4-yl)aniline
CAS No:5585-33-1
MF:C10H14N2O
MW:178.230962276459
MDL:MFCD00047408
CID:85402
PubChem ID:253662590
Update Time:2025-10-23

2-(morpholin-4-yl)aniline Chemical and Physical Properties

Names and Identifiers

    • 2-(4-Morpholino)aniline
    • 4-(2-Aminophenyl)morpholine
    • 2-Morpholinoaniline
    • 2-morpholin-4-ylaniline
    • 2-Morpholin-4-yl-phenylamine
    • 2-(Morpholin-4-yl)aniline
    • 2-(4-Morpholinyl)Aniline
    • 2-morpholin-4-ylphenylamine
    • Enamine_000782
    • n-(2-aminophenyl)morpholine
    • Oprea1_607645
    • Oprea1_339853
    • MLS000556407
    • (2-morpholin-4-ylphenyl)amine
    • N-(2-amino-phenyl) morpholine
    • QKWLVAYDAHQML
    • 1-[(2,4,6-trimethylphenyl)methyl]-1,4-diazepane;2-Morpholinoaniline
    • Z56785490
    • AC7767
    • SDCCGMLS-0065842.P001
    • FT-0608680
    • SCHEMBL127620
    • BB 0245672
    • MFCD00047408
    • PB36FZG3HN
    • Morpholine, 4-(o-aminophenyl)-
    • CHEMBL1333997
    • SY013914
    • 2-Morpholinoaniline, 97%
    • AKOS000103049
    • CS-0127962
    • M2671
    • HMS2384G11
    • J-510127
    • (2-Morpholinophenyl)amine
    • 11G-330S
    • QKWLVAYDAHQMLG-UHFFFAOYSA-N
    • A830840
    • HMS1396D12
    • DTXSID30352822
    • SMR000147724
    • STR01982
    • 2-(4-Morpholinyl)benzenamine
    • LWV
    • 5585-33-1
    • EN300-30032
    • Benzenamine, 2-(4-morpholinyl)-
    • 2-morpholinobenzenamine
    • STK088113
    • 2-(morpholin-4-yl)aniline
    • MDL： MFCD00047408
    • Inchi： 1S/C10H14N2O/c11-9-3-1-2-4-10(9)12-5-7-13-8-6-12/h1-4H,5-8,11H2
    • InChI Key： QKWLVAYDAHQMLG-UHFFFAOYSA-N
    • SMILES： O1CCN(C2C=CC=CC=2N)CC1
    • BRN： 163926

Computed Properties

  • Exact Mass: 178.11100
  • Monoisotopic Mass: 178.111
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 13
  • Rotatable Bond Count: 1
  • Complexity: 157
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: 1
  • Topological Polar Surface Area: 38.5

Experimental Properties

  • Color/Form: Not determined
  • Density: 1.149
  • Melting Point: 94.0 to 98.0 deg-C
  • Boiling Point: 120°C/0.6mmHg(lit.)
  • Flash Point: 154.9℃
  • Refractive Index: 1.589
  • PSA: 38.49000
  • LogP: 1.75160
  • Solubility: Not determined

2-(morpholin-4-yl)aniline Security Information

2-(morpholin-4-yl)aniline Customs Data

  • HS CODE：2934999090
  • Customs Data：

    China Customs Code:

    2934999090

    Overview:

    2934999090. Other heterocyclic compounds. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-(morpholin-4-yl)aniline Pricemore >>

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2-(morpholin-4-yl)aniline Related Literature

Related Categories

Additional information on 2-(morpholin-4-yl)aniline

Comprehensive Overview of 2-(morpholin-4-yl)aniline (CAS No. 5585-33-1): Properties, Applications, and Industry Insights

2-(morpholin-4-yl)aniline (CAS No. 5585-33-1), also known as N-(2-aminophenyl)morpholine, is a versatile organic compound with significant relevance in pharmaceutical and chemical research. This aromatic amine derivative features a morpholine ring attached to an aniline backbone, making it a valuable intermediate in synthetic chemistry. Its molecular formula is C10H14N2O, and it exhibits unique physicochemical properties that cater to diverse industrial applications.

In recent years, the demand for 2-(morpholin-4-yl)aniline has surged due to its role in developing drug candidates and agrochemicals. Researchers frequently search for "synthesis methods for 5585-33-1" or "2-(morpholin-4-yl)aniline suppliers," reflecting its commercial and academic importance. The compound’s electron-rich nitrogen atoms enable participation in cross-coupling reactions, a hot topic in green chemistry and catalysis.

From a structural perspective, the morpholine moiety enhances solubility and bioavailability, a critical factor in medicinal chemistry. This aligns with trending queries like "how to improve drug solubility using heterocycles." The compound’s melting point (typically 80–85°C) and stability under ambient conditions make it suitable for scalable processes, addressing industry concerns about cost-effective synthesis.

Beyond pharmaceuticals, 2-(morpholin-4-yl)aniline is explored in material science, particularly in designing organic semiconductors and photocatalysts. Searches for "aniline derivatives in OLEDs" highlight this niche application. Its fluorescence properties also attract attention in bioimaging studies, resonating with the growing interest in theranostic agents.

Regulatory compliance is another focal point. While 5585-33-1 is not classified as hazardous, proper storage conditions (e.g., inert atmosphere, moisture-free) are often queried to ensure longevity. Analytical techniques like HPLC and NMR are essential for purity verification, a recurring theme in "quality control for specialty chemicals" discussions.

In conclusion, 2-(morpholin-4-yl)aniline exemplifies the intersection of innovation and practical utility. Its adaptability to sustainable synthesis protocols and alignment with cutting-edge research ensure its continued prominence in scientific literature and industrial workflows.

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