• 1. A chiral bicyclo[2.2.2]octa-2,5-diene ligand substituted with the ferrocenyl group and its use for rhodium-catalyzed asymmetric 1,4-addition reactions
  Bo Zhou,Chau Ming So,Yixin Lu,Tamio Hayashi Org. Chem. Front. 2015 2 127
• 2. Tunable coordination of a tropos phosphite for fine-tuning of the Rh catalyzed asymmetric addition of phenylboronic acid to cyclohexenone
  Anna Iuliano,Sarah Facchetti,Tiziana Funaioli phosphite for fine-tuning of the Rh catalyzed asymmetric addition of phenylboronic acid to cyclohexenone. Anna Iuliano Sarah Facchetti Tiziana Funaioli Chem. Commun. 2009 457
• 3. Enantioselective conjugate addition of phenylboronic acid to enones catalysed by a chiral tropos/atropos rhodium complex at the coalescence temperature
  Chiara Monti,Cesare Gennari,Umberto Piarulli Chem. Commun. 2005 5281
• 4. Asymmetric 1,4-addition of triarylbismuths to enones catalyzed by dicationic palladium(ii) complexes
  Takashi Nishikata,Yasunori Yamamoto,Norio Miyaura Chem. Commun. 2004 1822
• 5. A new chiral di-N-heterocyclic carbene (NHC) cyclophane ligand and its application in palladium enantioselective catalysis
  Matthew S. Jeletic,Ion Ghiviriga,Khalil A. Abboud,Adam S. Veige Dalton Trans. 2010 39 6392

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzene and substituted derivatives
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives
• Solvents and Organic Chemicals Organic Compounds Aldehyde/Ketone

Comprehensive Guide to (R)-3-Phenyl-cyclohexanone (CAS No. 34993-51-6): Properties, Applications, and Industry Insights

(R)-3-Phenyl-cyclohexanone (CAS No. 34993-51-6) is a chiral organic compound widely recognized for its versatile applications in pharmaceuticals, agrochemicals, and specialty chemicals. As a key intermediate in asymmetric synthesis, this compound has garnered significant attention due to its stereoselective properties and potential in drug development. Researchers and manufacturers frequently search for terms like "(R)-3-Phenyl-cyclohexanone synthesis", "CAS 34993-51-6 uses", and "chiral cyclohexanone derivatives", reflecting its growing relevance in modern chemistry.

The compound's molecular structure features a phenyl group attached to the cyclohexanone ring at the 3-position, with the (R)-enantiomer exhibiting distinct reactivity patterns. Recent studies highlight its role in producing optically active pharmaceuticals, such as antidepressants and antiviral agents, aligning with the industry's shift toward enantiomerically pure drugs. Searches for "green synthesis of (R)-3-Phenyl-cyclohexanone" and "biocatalytic routes for chiral ketones" underscore the demand for sustainable production methods.

From a technical perspective, 34993-51-6 demonstrates notable stability under standard conditions, with a melting range of 45–48°C and a molecular weight of 174.24 g/mol. Its lipophilic character makes it suitable for formulations requiring controlled release, a topic frequently explored in forums discussing "drug delivery enhancers" and "pharmacokinetic modifiers". Analytical techniques like HPLC and chiral GC are commonly employed to verify its enantiomeric purity, addressing quality concerns raised in queries such as "how to test (R)-3-Phenyl-cyclohexanone purity".

Innovative applications of (R)-3-Phenyl-cyclohexanone extend to fragrance synthesis, where its ketone functionality serves as a precursor for musk-like compounds. This aligns with trending searches for "sustainable aroma chemicals" and "non-animal-derived fragrance ingredients". Furthermore, its use in liquid crystal formulations for electronics has sparked interest in keywords like "advanced material intermediates" and "high-performance organic compounds".

Regulatory compliance remains a critical consideration for users of CAS No. 34993-51-6. While not classified as hazardous under major chemical inventories, proper handling guidelines are often sought using terms like "(R)-3-Phenyl-cyclohexanone safety data" and "storage conditions for chiral ketones". The compound's biodegradability profile and low ecotoxicity make it preferable for environmentally conscious applications, resonating with searches for "green chemistry building blocks".

Market analyses reveal increasing demand for enantiomerically pure (R)-3-Phenyl-cyclohexanone, particularly in Asia-Pacific pharmaceutical hubs. This trend correlates with search volume spikes for "CAS 34993-51-6 suppliers" and "bulk chiral compound manufacturers". Recent patent filings involving derivatives of this compound further validate its commercial potential, addressing niche queries like "novel uses of 3-phenylcyclohexanone" and "recent patents on chiral intermediates".

For researchers exploring structure-activity relationships, the conformational flexibility of (R)-3-Phenyl-cyclohexanone offers intriguing possibilities. Computational chemistry studies frequently reference this compound when investigating "molecular docking simulations" and "chiral recognition mechanisms"—topics generating substantial academic interest. The compound's hydrogenation potential also features prominently in discussions about "asymmetric reduction catalysts" and "stereocontrolled synthesis".

Quality control protocols for 34993-51-6 typically emphasize chiral HPLC analysis and spectroscopic verification, addressing common purchaser concerns reflected in searches for "analytical methods for chiral purity". The compound's shelf life and stability data—often queried as "(R)-3-Phenyl-cyclohexanone degradation factors"—are crucial for industrial users requiring long-term storage solutions.

Emerging research directions include the compound's potential in metal-organic frameworks (MOFs) and as a template for molecularly imprinted polymers. These cutting-edge applications respond to growing searches for "functional material precursors" and "smart polymer substrates", positioning (R)-3-Phenyl-cyclohexanone as a compound with untapped potential across multiple scientific disciplines.

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• 762243-26-5(5-(3-Methylphenyl)cyclohexane-1,3-dione)
• 61888-37-7(5-(4-Methylphenyl)cyclohexane-1,3-dione)