A new chiral di-N-heterocyclic carbene (NHC) cyclophane ligand and its application in palladium enantioselective catalysis?

Dalton Transactions Pub Date: 2010-06-21 DOI: 10.1039/C0DT00268B

Abstract

This report details the synthesis and characterization of the first chiral diNHC cyclophane ligand and its palladium allyl complex. The complex was tested for 1,4-conjugate addition of phenylboronic acid to 2-cyclohexen-1-one and provides R-3-phenylcyclohexanone in 50% enantiomeric excess.

Graphical abstract: A new chiral di-N-heterocyclic carbene (NHC) cyclophane ligand and its application in palladium enantioselective catalysis
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