Production Method 1

90-05-1

2444-28-2

120-95-6

1620-98-0

1020-31-1

4130-42-1

2934-05-6

59056-76-7

5076-72-2

94-71-3

52417-48-8

876-20-0

33963-27-8

87-97-8

79-74-3

2050-46-6

17540-75-9

2934-07-8

131358-04-8

21112-37-8

2078-54-8

Reaction Conditions

1.1 Catalysts: Tungstic acid (H2WO4) ;  rt → 300 °C; 6 h, 300 °C

Reference

Highly selective conversion of guaiacol to tert-butylphenols in supercritical ethanol over a H2WO4 catalyst

Mai, Fuhang; et al, RSC Advances, 2019, 9(5), 2764-2771

2,6-Bis(1,1-dimethylethyl)-1,4-benzenediol (Technical Grade) Raw materials

• Guaiacol

2,6-Bis(1,1-dimethylethyl)-1,4-benzenediol (Technical Grade) Preparation Products

• 2,4-bis(2-methylbutan-2-yl)phenol (120-95-6)
• 3,5-Di-tert-butyl-4-hydroxybenzaldehyde (1620-98-0)
• 3,5-Di-tert-butylcatechol (1020-31-1)
• 2,6-Di-tert-butyl-4-ethylphenol (4130-42-1)
• 2,4-Diisopropylphenol (2934-05-6)
• Benzene, 4-butyl-1,2-dimethoxy- (59056-76-7)
• Benzene,1-ethoxy-4-methoxy- (5076-72-2)
• 2-Ethoxyphenol (94-71-3)
• 2-(2,5-dimethoxyphenyl)propanal (52417-48-8)
• 2-Phenylethyl-1,1,2,2-d4-amine (876-20-0)
• 4-Ethoxy-3-methoxytoluene (33963-27-8)
• Phenol,2,6-bis(1,1-dimethylethyl)-4-(methoxymethyl)- (87-97-8)
• 2,5-Di-tert-amylhydroquinone (79-74-3)
• 1,2-Diethoxybenzene (2050-46-6)
• 4-Sec-Butyl-2,6-di-tert-butylphenol (17540-75-9)
• Phenol,2,4,6-tris(1-methylethyl)- (2934-07-8)
• 1,2-Diethoxy-4-ethylbenzene (131358-04-8)
• Benzene,2-(1,1-dimethylethyl)-1,4-dimethoxy- (21112-37-8)
• Propofol (2078-54-8)

• 1. A green mesostructured vanadosilicate catalyst and its unprecedented catalytic activity for the selective synthesis of 2,6-disubstituted p-benzoquinones
  M. Selvaraj,S. B. Park,J. M. Kim Dalton Trans. 2014 43 958
• 2. Enantioselective synthesis of (+)(R)- and (?)(S)-nicotine based on Ir-catalysed allylic amination
  Carolin Welter,Rosa M. Moreno,Stephane Streiff,Günter Helmchen Org. Biomol. Chem. 2005 3 3266
• 3. QSAR for the cytotoxicity of 2-alkyl or 2,6-dialkyl, 4-X-phenols: the nature of the radical reaction
  Cynthia D. Selassie,Rajeshwar P. Verma,Sanjay Kapur,Alan J. Shusterman,Corwin Hansch J. Chem. Soc. Perkin Trans. 2 2002 1112
• 4. Highly active and green mesostructured titanosilicate catalysts synthesized for selective synthesis of benzoquinones
  M. Selvaraj Catal. Sci. Technol. 2014 4 2674
• 5. Selective synthesis of benzoquinones over Cu(ii)-containing propylsalicylaldimine functionalized mesoporous solid catalysts
  Manickam Selvaraj,Mohammed A. Assiri Dalton Trans. 2019 48 3291

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylpropanes

Comprehensive Introduction to 2,6-Bis(1,1-dimethylethyl)-1,4-benzenediol (CAS No. 2444-28-2) - Technical Grade Applications and Industry Insights

2,6-Bis(1,1-dimethylethyl)-1,4-benzenediol, commonly referred to by its CAS number 2444-28-2, is a high-performance phenolic antioxidant widely utilized in industrial applications. This technical grade compound plays a critical role in polymer stabilization, particularly in enhancing the durability of synthetic materials under oxidative stress. Its molecular structure, featuring two tertiary butyl groups, provides exceptional radical-scavenging properties, making it a preferred choice for manufacturers seeking to extend product lifespans.

Recent trends in sustainable material science have amplified interest in 2444-28-2, as industries seek eco-friendly stabilizers that comply with REACH regulations. The compound's effectiveness at low concentrations (typically 0.1-0.5% w/w) aligns perfectly with the green chemistry movement's emphasis on minimal additive usage. Research indicates growing applications in biodegradable plastics, where it helps maintain mechanical properties during composting cycles - a hot topic in 2024 circular economy discussions.

The technical grade specification of 2,6-Bis(1,1-dimethylethyl)-1,4-benzenediol indicates purity levels (usually 95-98%) suitable for industrial processes rather than pharmaceutical applications. This grade demonstrates excellent compatibility with polyolefins, elastomers, and adhesives - three material categories experiencing surging demand in electric vehicle components and renewable energy infrastructure. Analytical techniques like HPLC and GC-MS are routinely employed to verify its stability performance in these matrices.

Frequently searched questions about CAS 2444-28-2 include its thermal decomposition profile (stable up to 280°C) and synergistic effects with phosphite co-stabilizers. Industry professionals particularly value its low volatility compared to smaller phenolic antioxidants, a property that reduces fogging issues in automotive interior applications. The compound's molecular weight (220.35 g/mol) and logP value (4.2) make it ideal for systems requiring migration-resistant additives.

Emerging research directions for 2,6-Bis(1,1-dimethylethyl)-1,4-benzenediol technical grade explore its potential in 3D printing filaments and recycled polymer stabilization. With global plastic recycling rates projected to double by 2030, this antioxidant's ability to protect polymers through multiple processing cycles positions it as a key enabler for closed-loop material systems. Its regulatory status (approved for food contact applications in many jurisdictions) further enhances its market attractiveness.

From a supply chain perspective, 2444-28-2 demonstrates excellent storage stability when kept in amber containers below 30°C, addressing common logistical concerns. Manufacturers emphasize its cost-performance ratio compared to newer synthetic antioxidants, particularly in engineering plastics like POM and PA66. The technical grade's characteristic white to light yellow crystalline appearance serves as a quick visual quality indicator for bulk purchasers.

Advanced formulation strategies now combine 2,6-Bis(1,1-dimethylethyl)-1,4-benzenediol with UV absorbers for comprehensive light and heat stabilization - a formulation approach trending in solar panel encapsulation materials. Its hydroxyl group reactivity also enables covalent bonding to polymer backbones in innovative reactive antioxidant systems, a cutting-edge development in polymer chemistry publications.

• 88-60-8(2-tert-butyl-5-methylphenol)
• 79955-60-5(1,3-Benzenediol, 2-(1,1-dimethylethyl)-5-methyl-)
• 66604-75-9(1,4-Benzenediol, 2-(1,1-dimethylethyl)-5-(1-methyl-1-phenylethyl)-)
• 1948-33-0(tert-Butylhydroquinone)
• 88-58-4(2,5-Di-tert-butylhydroquinone)
• 2349-78-2(1,4-Benzenediol,2-(1,1-dimethylethyl)-5-(1-methylethyl)-)
• 5875-45-6(Phenol,2,5-bis(1,1-dimethylethyl)-)
• 5419-54-5(Phenol,2,2'-(1-methylethylidene)bis[5-methyl-)
• 66604-76-0(1,4-Benzenediol, 2-methyl-5-(1-methyl-1-phenylethyl)-)
• 85797-61-1(1,4-Benzenediol, 2-(1-methyl-1-phenylethyl)-)