Production Method 1

88-60-8

Reaction Conditions

1.1 Catalysts: Aluminum ;  30 min, rt → 130 °C
1.2 3 h, 130 °C

Reference

Synthesis of 3-methyl-6-tert-butyl phenol

Wang, Guangxing; Wang, Shoukai; Jiao, Bin; Wang, Lili, Guangdong Huagong, 2014, 41(5), 43-44

Production Method 2

1118-12-3

88-60-8

Reaction Conditions

1.1 Reagents: Sulfuric acid

Reference

Use of urea and its N-substituted tert-butyl derivatives in tert-butylation of aromatic compounds

Nevrekar, Nitin B.; Sawardekar, Sagar R.; Pandit, Tushar S.; Kudav, Narayan A., Chemistry & Industry (London, 1983, (5), 206-7

Production Method 3

88-60-8

Reaction Conditions

1.1 Reagents: Urea ,  Sulfuric acid Solvents: Water ;  2 h, 10 - 25 °C
1.2 0 - 5 °C; 3 h, rt

Reference

Synthesis and insecticidal activities and SAR studies of novel benzoheterocyclic diacylhydrazine derivatives

Huang, Zhiqiang; Cui, Quanmin; Xiong, Lixia; Wang, Ziwen; Wang, Kaiyun; et al, Journal of Agricultural and Food Chemistry, 2009, 57(6), 2447-2456

Production Method 4

88-60-8

Reaction Conditions

1.1 Catalysts: 12-Tungstophosphoric acid ;  6 h, 80 °C

Reference

Supported 12-tungstophosphoric acid: An efficient and selective solid acid catalyst for tert-butylation of phenol and cresols

Bhatt, Nikunj; Sharma, Pankaj; Patel, Anjali; Selvam, Parasuraman, Catalysis Communications, 2008, 9(7), 1545-1550

Production Method 5

88-60-8

Reaction Conditions

Reference

Selective process for preparing 2,4- or 3,6-disubstituted phenol compounds

, European Patent Organization, , ,

Production Method 6

88-60-8

Reaction Conditions

Reference

Preparation of 2,4-dichloro-3-methylphenol as an herbicide intermediate

, Federal Republic of Germany, , ,

Production Method 7

9005-53-2

88-60-8

87-85-4

2219-78-5

1758-88-9

13037-79-1

15181-13-2

13632-94-5

876-20-0

622-96-8

1687-64-5

527-84-4

700-12-9

3698-49-5

92617-73-7

89-83-8

35946-91-9

3238-38-8

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium ,  Chromium chloride (CrCl3) Solvents: Methanol ;  4 h, 2 MPa, 280 °C

Reference

Insight into the solvent, temperature and time effects on the hydrogenolysis of hydrolyzed lignin

Shu, Riyang; Zhang, Qi; Ma, Longlong; Xu, Ying; Chen, Pengru; et al, Bioresource Technology, 2016, 221, 568-575

Production Method 8

88-60-8

Reaction Conditions

1.1 Reagents: Sulfuric acid ;  rt → 75 °C; 3 h, 80 °C
1.2 Reagents: Sodium hydroxide Solvents: Water
1.3 Reagents: Sulfuric acid Solvents: Water

Reference

Synthesis of 3-methyl-6-tert-butylphenol

Lu, Jiu-zhou; Feng, Lei; Xu, Ya-xian; Chai, Jin-rong; Shen, Jing, Jingxi Huagong, 2003, 20(11), 685-688

Production Method 9

88-60-8

Reaction Conditions

1.1 383 K

Reference

Synthesis of 2-tert-butyl-5-methylphenol catalyzed by HY zeolite

Yang, Jianguo; Cheng, Zhilin; Xue, Qingsong; Yu, Xinyu; He, Mingyuan, Shiyou Huagong, 2004, 33(10), 916-919

Production Method 10

88-40-4

88-60-8

Reaction Conditions

Reference

Cleavage of ethers and geminal diacetates using the boron triiodide-N,N-diethylaniline complex

Narayana, Chatla; Padmanabhan, Seetharamaiyer; Kabalka, George W., Tetrahedron Letters, 1990, 31(48), 6977-8

Production Method 11

88-60-8

Reaction Conditions

1.1 Reagents: Urea ,  Sulfuric acid Solvents: Water ;  2 h, rt
1.2 rt

Reference

Preparation of N-(2,3-dihydro-2,4-dimethylbenzofuran-5-acyl)-N'-tert-butyl-N'-(substituted benzoyl)-hydrazines as insecticides

, China, , ,

Production Method 12

88-60-8

Reaction Conditions

1.1 Catalysts: 12-Tungstophosphoric acid ;  6 h, 80 °C

Reference

12-tungstophosphoric and 12-tungstosilicic acid supported onto hydrous zirconia for liquid phase tert-butylation of m-cresol

Bhatt, Nikunj; Shah, Charul; Patel, Anjali, Catalysis Letters, 2007, 117(3-4), 146-152

2-tert-butyl-5-methylphenol Raw materials

• Lignin
• N-tert-Butylurea
• Benzene,1-(1,1-dimethylethyl)-2-methoxy-4-methyl-

2-tert-butyl-5-methylphenol Preparation Products

• 2-tert-butyl-5-methylphenol (88-60-8)
• Hexamethylbenzene (87-85-4)
• Phenol,2-ethyl-4,5-dimethyl- (2219-78-5)
• 2-Ethyl-1,4-dimethylbenzene (1758-88-9)
• Phenol,2-(1,1-dimethylethyl)-3-methyl- (13037-79-1)
• Benzene,1-ethyl-3,5-bis(1-methylethyl)- (15181-13-2)
• Benzene,1,4-diethyl-2-methyl- (13632-94-5)
• 2-Phenylethyl-1,1,2,2-d4-amine (876-20-0)
• 4-Ethyltoluene (622-96-8)
• 2-Ethyl-6-methylphenol (1687-64-5)
• o-Cymene (527-84-4)
• 1,2,3,4,5-pentamethylbenzene (700-12-9)
• 2,3-Dihydro-2,2,4,6-tetramethylbenzofuran (3698-49-5)
• Phenol, 2-(1,1-dimethyl-2-propen-1-yl)-3,6-dimethyl- (92617-73-7)
• Thymol (89-83-8)
• 2,5-Diisopropylphenol (35946-91-9)
• Phenol,2,3,4,6-tetramethyl- (3238-38-8)

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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylpropanes
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

• 79955-60-5(1,3-Benzenediol, 2-(1,1-dimethylethyl)-5-methyl-)
• 66604-75-9(1,4-Benzenediol, 2-(1,1-dimethylethyl)-5-(1-methyl-1-phenylethyl)-)
• 1948-33-0(tert-Butylhydroquinone)
• 88-58-4(2,5-Di-tert-butylhydroquinone)
• 2349-78-2(1,4-Benzenediol,2-(1,1-dimethylethyl)-5-(1-methylethyl)-)
• 2444-28-2(2,6-Bis(1,1-dimethylethyl)-1,4-benzenediol (Technical Grade))
• 5875-45-6(Phenol,2,5-bis(1,1-dimethylethyl)-)
• 5419-54-5(Phenol,2,2'-(1-methylethylidene)bis[5-methyl-)
• 66604-76-0(1,4-Benzenediol, 2-methyl-5-(1-methyl-1-phenylethyl)-)
• 85797-61-1(1,4-Benzenediol, 2-(1-methyl-1-phenylethyl)-)