Enantioselective synthesis of (+)(R)- and (?)(S)-nicotine based on Ir-catalysed allylic amination?

Organic & Biomolecular Chemistry Pub Date: 2005-08-11 DOI: 10.1039/B508634E

Abstract

The synthesis of nicotine with enantiomeric excess of >99% ee was accomplished by asymmetric Ir-catalysed allylic amination followed by ring closing metathesis and racemisation-free double bond reduction.

Graphical abstract: Enantioselective synthesis of (+)(R)- and (?)(S)-nicotine based on Ir-catalysed allylic amination
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