Production Method 1

65039-03-4

98837-98-0

110-15-6

2314-78-5

106-65-0

1121-07-9

123-25-1

627-73-6

925-93-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Carbon dioxide ,  1-Ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ;  160 bar, rt → 150 °C; 18 h, 150 °C

Reference

Valuable new platform chemicals obtained by valorisation of a model succinic acid and bio-succinic acid with an ionic liquid and high-pressure carbon dioxide

Silva, Daniel; Bogel-Lukasik, Ewa, Green Chemistry, 2017, 19(17), 4048-4060

N-Ethylsuccinimide Raw materials

• 1H-Imidazolium,3-ethyl-1-methyl-
• N-Propyl-Methyl Piperidinium Bis(trifluoroMethylsulfonyl)Imide
• butanedioic acid

N-Ethylsuccinimide Preparation Products

• Dimethyl succinate (106-65-0)
• N-Methylsuccinimide (1121-07-9)
• Diethyl succinate (123-25-1)
• N-Ethylsuccinimide (2314-78-5)
• ethyl methyl butanedioate (627-73-6)
• Ethanol-d (925-93-9)

• 1. Switchable regioselective hydroalkylation of 2-arylindoles with maleimides
  Dhananjay S. Nipate,Vikki N. Shinde,Krishnan Rangan,Anil Kumar Org. Biomol. Chem. 2021 19 4910
• 2. Valuable new platform chemicals obtained by valorisation of a model succinic acid and bio-succinic acid with an ionic liquid and high-pressure carbon dioxide
  Daniel Silva,Ewa Bogel-?ukasik Green Chem. 2017 19 4048
• 3. An odorless thia-Michael addition using Bunte salts as thiol surrogates
  Ya-mei Lin,Guo-ping Lu,Chun Cai,Wen-bin Yi RSC Adv. 2015 5 27107
• 4. A hydrogen-driven biocatalytic approach to recycling synthetic analogues of NAD(P)H
  Holly A. Reeve,Jake Nicholson,Farieha Altaf,Thomas H. Lonsdale,Janina Preissler,Lars Lauterbach,Oliver Lenz,Silke Leimkühler,Frank Hollmann,Caroline E. Paul,Kylie A. Vincent Chem. Commun. 2022 58 10540
• 5. Application of gas chromatography-mass spectrometry and chemometrics methods for assessing volatile profiles of Pu-erh tea with different processing methods and ageing years
  Shidong Lv,Yuanshuang Wu,Jifu Wei,Ming Lian,Chen Wang,Xuemei Gao,Qingxiong Meng RSC Adv. 2015 5 87806

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Carboxylic acid derivatives Carboxylic acid imides

N-Ethylsuccinimide (CAS No: 2314-78-5) in Modern Chemical and Pharmaceutical Research

N-Ethylsuccinimide (CAS No: 2314-78-5) is a significant compound in the field of organic chemistry and pharmaceutical research, renowned for its versatile applications in drug synthesis and biochemical studies. This heterocyclic compound, characterized by its succinimide core structure, has garnered considerable attention due to its role as an intermediate in the development of various therapeutic agents. Its unique chemical properties make it a valuable building block for medicinal chemists, enabling the creation of complex molecules with potential pharmacological activity.

The structural framework of N-Ethylsuccinimide consists of a five-membered ring containing two nitrogen atoms, with an ethyl group attached to one of the nitrogen atoms. This configuration imparts distinct reactivity and stability, making it suitable for a wide range of chemical transformations. In pharmaceutical applications, it serves as a precursor in the synthesis of anticonvulsant drugs, particularly those used to treat epilepsy. The compound's ability to undergo nucleophilic substitution reactions allows for further functionalization, enabling the development of derivatives with enhanced therapeutic profiles.

Recent advancements in the field have highlighted the importance of N-Ethylsuccinimide in the development of novel bioactive molecules. For instance, researchers have explored its utility in designing inhibitors targeting specific enzymatic pathways involved in neurological disorders. The compound's scaffold has been modified to create molecules that exhibit potent activity against voltage-gated sodium channels, which are critical in regulating neuronal excitability. These findings underscore the compound's significance as a pharmacophore in drug discovery efforts.

Moreover, N-Ethylsuccinimide has found applications beyond traditional pharmaceuticals. In synthetic organic chemistry, it is employed as a protecting group for carboxylic acids and as a ligand in transition metal-catalyzed reactions. Its role in facilitating cross-coupling reactions has been particularly noteworthy, enabling the construction of complex organic frameworks with precision. These synthetic applications demonstrate the compound's broad utility and its contribution to advancing chemical methodologies.

The industrial production of N-Ethylsuccinimide is typically achieved through catalytic hydrogenation or oxidation processes starting from succinic acid derivatives. These methods ensure high yield and purity, making the compound readily available for research and commercial purposes. The scalability of its synthesis underscores its practicality in large-scale pharmaceutical manufacturing, where consistent quality and supply are paramount.

In academic research, N-Ethylsuccinimide continues to be a subject of investigation due to its unique chemical properties and potential therapeutic applications. Studies have examined its interactions with biological targets, providing insights into its mechanism of action and potential side effects. These investigations are crucial for developing safer and more effective drugs based on this scaffold. Additionally, computational modeling techniques have been employed to predict the behavior of N-Ethylsuccinimide derivatives, further accelerating drug discovery processes.

The compound's stability under various conditions has also been a focus of research. Investigations into its thermal and photochemical properties have revealed that it can be modified under controlled conditions without significant degradation. This stability is essential for ensuring the efficacy of drugs derived from this compound throughout their shelf life. Furthermore, studies on its solubility profile have led to innovative formulations that enhance bioavailability and therapeutic delivery.

Looking ahead, the future prospects for N-Ethylsuccinimide appear promising as new research avenues continue to emerge. The integration of machine learning and artificial intelligence into drug discovery has opened up possibilities for identifying novel derivatives with enhanced properties. By leveraging these technologies, researchers can explore vast chemical spaces efficiently, potentially uncovering new therapeutic agents based on the N-Ethylsuccinimide scaffold.

The versatility of N-Ethylsuccinimide extends beyond pharmaceuticals into materials science and agrochemicals. Its derivatives have been investigated for their potential use in polymer synthesis and as intermediates in crop protection agents. These applications highlight the compound's broad utility across multiple scientific disciplines.

In conclusion, N-Ethylsuccinimide (CAS No: 2314-78-5) remains a cornerstone in chemical and pharmaceutical research due to its diverse applications and structural versatility. Its role as an intermediate in drug synthesis, coupled with its unique chemical properties, continues to drive innovation in medicinal chemistry. As research progresses, new applications and derivatives are likely to emerge, further solidifying its importance in scientific endeavors.

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