A hydrogen-driven biocatalytic approach to recycling synthetic analogues of NAD(P)H?
Chemical Communications Pub Date: 2022-08-18 DOI: 10.1039/D2CC02411J
Abstract
We demonstrate a recycling system for synthetic nicotinamide cofactor analogues using a soluble hydrogenase with turnover number of >1000 for reduction of the cofactor analogues by H2. Coupling this system to an ene reductase, we show quantitative conversion of N-ethylmaleimide to N-ethylsuccinimide. The biocatalyst system retained >50% activity after 7 h.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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