Production Method 1

65039-03-4

98837-98-0

110-15-6

106-65-0

1121-07-9

123-25-1

2314-78-5

627-73-6

925-93-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Carbon dioxide ,  1-Ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ;  160 bar, rt → 150 °C; 18 h, 150 °C

Reference

Valuable new platform chemicals obtained by valorisation of a model succinic acid and bio-succinic acid with an ionic liquid and high-pressure carbon dioxide

Silva, Daniel; Bogel-Lukasik, Ewa, Green Chemistry, 2017, 19(17), 4048-4060

Dimethyl succinate Raw materials

• 1H-Imidazolium,3-ethyl-1-methyl-
• N-Propyl-Methyl Piperidinium Bis(trifluoroMethylsulfonyl)Imide
• butanedioic acid

Dimethyl succinate Preparation Products

• Dimethyl succinate (106-65-0)
• N-Methylsuccinimide (1121-07-9)
• Diethyl succinate (123-25-1)
• N-Ethylsuccinimide (2314-78-5)
• ethyl methyl butanedioate (627-73-6)
• Ethanol-d (925-93-9)

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• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Fatty Acyls Fatty acid methyl esters
• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Fatty Acyls Fatty acid esters Fatty acid methyl esters
• Natural Products and Extracts Flavors and Fragrances Essential Oils
• Solvents and Organic Chemicals Organic Compounds Acids/Esters
• Natural Products and Extracts Flavors and Fragrances
• Pharmaceutical and Biochemical Products Pharmaceutical Active Ingredients

Dimethyl succinate (CAS No. 106-65-0): A Versatile Intermediate in Modern Chemical Biology and Pharmaceutical Research

Dimethyl succinate, with the chemical formula C?H??O?, is a significant compound identified by the CAS number 106-65-0. This dicarboxylate ester has garnered considerable attention in the realms of chemical biology and pharmaceutical research due to its versatile applications and structural properties. As a derivative of succinic acid, it serves as a crucial intermediate in various synthetic pathways, enabling the development of complex molecules that are pivotal in drug discovery and material science.

The compound's molecular structure, featuring two ester groups linked to a four-carbon backbone, makes it an attractive candidate for further functionalization. This structural flexibility allows Dimethyl succinate to participate in a wide array of chemical reactions, including esterification, hydrolysis, and condensation reactions, which are fundamental to the synthesis of bioactive molecules. Its role as a building block in organic synthesis has been leveraged in the development of polymers, fragrances, and specialty chemicals, underscoring its industrial relevance.

In recent years, Dimethyl succinate has found prominence in the field of drug development. Its derivatives have been explored as potential therapeutic agents due to their ability to modulate biological pathways. For instance, studies have highlighted its utility in the synthesis of succinylated peptides, which exhibit enhanced stability and bioavailability. These modifications are critical for improving the pharmacokinetic profiles of peptide-based drugs, making them more effective in clinical settings.

The compound's significance extends to its application in metabolic engineering and synthetic biology. Researchers have utilized Dimethyl succinate as a precursor in the biosynthesis of valuable chemicals. By integrating this compound into microbial fermentation processes, scientists have been able to produce high-value metabolites that are otherwise challenging to obtain through traditional chemical synthesis. This approach aligns with the growing trend toward sustainable and green chemistry practices.

Moreover, Dimethyl succinate has been investigated for its potential role in energy storage solutions. Its esterase-cleavable nature makes it an ideal candidate for developing biodegradable polymers that can be used in rechargeable batteries. These materials offer a promising alternative to conventional battery components by providing better environmental compatibility and longer lifespans. The integration of such biodegradable materials into energy storage systems represents a significant advancement toward achieving renewable energy goals.

The pharmaceutical industry has also harnessed the capabilities of Dimethyl succinate in the development of novel drug delivery systems. Its ability to form stable complexes with active pharmaceutical ingredients (APIs) enhances drug solubility and bioavailability. This property is particularly beneficial for poorly soluble drugs that require innovative formulations to improve therapeutic efficacy. By leveraging the structural attributes of this compound, researchers have been able to design advanced drug delivery platforms that address critical challenges in medicinal chemistry.

In academic research, Dimethyl succinate continues to be a subject of interest due to its role as an intermediate in organic synthesis. Its participation in various reaction cascades has enabled the discovery of new synthetic methodologies that are more efficient and environmentally friendly. These advancements contribute to the broader goal of reducing the environmental impact of chemical manufacturing processes while maintaining high yields and purity standards.

The compound's versatility is further demonstrated by its application in agrochemical research. Derivatives of Dimethyl succinate have been explored as potential growth regulators and pest control agents. These applications highlight its potential beyond pharmaceuticals and into agricultural science, where sustainable solutions are increasingly sought after to meet global food demands without compromising environmental health.

The future prospects for Dimethyl succinate are promising, with ongoing research uncovering new applications across multiple disciplines. As synthetic methodologies continue to evolve, this compound is expected to play an even more integral role in the development of innovative materials and therapeutics. The collaborative efforts between academia and industry will likely drive further discoveries that harness its unique properties for societal benefit.

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