• 1. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
  Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
• 2. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 3. Excitation dependent bidirectional electron transfer in phthalocyanine-functionalised MoS2 nanosheets?
  Christopher J. Harrison,Kyle J. Berean,Enrico Della Gaspera,Jian Zhen Ou,Richard B. Kaner,Kourosh Kalantar-zadeh,Torben Daeneke Nanoscale, 2016,8, 16276-16283
• 4. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
• 5. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847

Comprehensive Analysis of 3-Chloropyridine-2-carbaldehyde (CAS No. 206181-90-0): Properties, Applications, and Industry Trends

3-Chloropyridine-2-carbaldehyde (CAS No. 206181-90-0) is a versatile organic compound widely utilized in pharmaceutical synthesis, agrochemical production, and specialty chemical research. This halogenated pyridine derivative features a reactive aldehyde group at the 2-position and a chlorine substituent at the 3-position, making it a valuable building block for heterocyclic chemistry. Recent studies highlight its role in developing biologically active molecules, particularly in kinase inhibitor design and antimicrobial agents, aligning with growing interest in targeted drug discovery.

The compound's molecular structure (C₆H₄ClNO) exhibits unique electronic properties due to the electron-withdrawing effects of both the chloro and formyl groups. Analytical characterization typically shows: melting point 58-62°C, boiling point 245-248°C, and solubility in common organic solvents like ethanol and dichloromethane. Advanced purification methods such as column chromatography or recrystallization achieve >98% purity for research applications, addressing the pharmaceutical industry's demand for high-purity intermediates.

In synthetic applications, 3-Chloropyridine-2-carbaldehyde serves as a precursor for Schiff base ligands in coordination chemistry and multicomponent reactions for nitrogen-containing heterocycles. A 2023 study demonstrated its efficacy in constructing imidazo[1,2-a]pyridine scaffolds through catalyst-free cyclization, reflecting the industry's shift toward green chemistry protocols. These findings respond to frequent search queries about eco-friendly synthetic methods and atom-efficient reactions.

Market analysis reveals increasing demand for this compound in Asia-Pacific regions, driven by expansion in contract research organizations (CROs) and generic drug manufacturing. Regulatory compliance with REACH and GMP standards ensures its safe handling in industrial settings. Storage recommendations include amber glass containers under inert atmosphere to prevent oxidative degradation, a common concern among laboratory users searching for compound stability solutions.

Emerging applications include its use in photocatalysis and electrochemical sensors, particularly for detecting heavy metal ions. Researchers are investigating its structure-activity relationships in medicinal chemistry projects, with computational studies predicting favorable ADMET properties for derived compounds. These developments address trending search terms like AI-assisted drug design and computational chemistry tools in pharmaceutical R&D.

Quality control protocols for CAS 206181-90-0 emphasize HPLC-UV analysis (typically ≥99% purity) and rigorous residual solvent testing. Suppliers increasingly provide certificates of analysis with detailed spectroscopic data (IR, NMR, MS), responding to buyer requirements for analytical documentation. The compound's shelf life extends beyond 24 months when stored at -20°C, a critical parameter for inventory management in research facilities.

Recent patent literature (2022-2024) describes novel applications in crop protection formulations and material science, particularly as a monomer for conductive polymers. These innovations correlate with search trends for sustainable agriculture solutions and organic electronics. The global market for pyridine derivatives is projected to grow at 6.2% CAGR through 2030, with 3-Chloropyridine-2-carbaldehyde maintaining significance in fine chemical supply chains.

Environmental considerations include biodegradability studies showing moderate persistence in aquatic systems, prompting development of green synthesis routes. Life cycle assessment (LCA) approaches are being applied to optimize production processes, aligning with ESG (Environmental, Social, and Governance) criteria increasingly searched by responsible sourcing professionals. Transportation regulations classify it as non-hazardous for limited quantities, facilitating global logistics.

Technical challenges in scaling up 3-Chloropyridine-2-carbaldehyde synthesis involve controlling regioisomer formation during chlorination steps. Process chemistry innovations include continuous flow reactors that improve yield (reported up to 87%) and reduce byproduct generation. These advancements answer frequent queries about process intensification and manufacturing optimization in specialty chemical production.

Academic and industrial researchers consistently rank this compound as valuable for constructing privileged structures in medicinal chemistry. Its balanced lipophilicity (calculated logP ~1.2) and molecular weight (141.55 g/mol) make it particularly useful in fragment-based drug discovery, a hot topic in pharmaceutical searches. Collaborative studies between academia and industry are exploring its potential in neglected disease research, particularly for tropical infections.

• 471909-65-6(3,5-dichloropyridine-2-carbaldehyde)
• 137778-17-7(5-chloro-6-methylpyridine-2-carbaldehyde)
• 31181-89-2(5-chloropyridine-2-carbaldehyde)
• 72093-03-9(3-Chloro-2-methylpyridine)
• 343781-53-3(3,6-Dichloropicolinaldehyde)
• 128073-02-9( )
• 56164-42-2(3-chloro-1H-pyrrole-2-carbaldehyde)
• 884495-43-6(2-Pyridinecarboxaldehyde,3-chloro-4-methyl-)
• 1227563-32-7(3-Chloro-5-fluoropyridine-2-carbaldehyde)
• 110912-15-7(3-Chloro-1H-indole-2-carbaldehyde)