• 1. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312
• 2. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
• 3. An alumina stabilized graphene oxide wrapped SnO2 hollow sphere LIB anode with improved lithium storage?
  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridine carboxaldehydes

Introduction to 5-Chloro-6-Methylpyridine-2-Carbaldehyde (CAS No. 137778-17-7)

5-Chloro-6-methylpyridine-2-carbaldehyde (CAS No. 137778-17-7) is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound, characterized by its unique chemical structure, exhibits a range of biological activities that make it a valuable candidate for various applications, including drug discovery and development.

The molecular formula of 5-chloro-6-methylpyridine-2-carbaldehyde is C₈H₇ClNO, and its molecular weight is approximately 160.60 g/mol. The compound features a pyridine ring with a chloro substituent at the 5-position and a methyl group at the 6-position, along with an aldehyde functional group at the 2-position. This specific arrangement of functional groups imparts unique chemical and physical properties to the molecule, making it an interesting subject for both academic and industrial research.

In recent years, the study of 5-chloro-6-methylpyridine-2-carbaldehyde has been driven by its potential as a lead compound in the development of novel therapeutic agents. Research has shown that this compound possesses significant biological activities, including anti-inflammatory, antimicrobial, and anticancer properties. For instance, a study published in the Journal of Medicinal Chemistry in 2021 demonstrated that derivatives of 5-chloro-6-methylpyridine-2-carbaldehyde exhibit potent anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines such as TNF-α and IL-6.

Beyond its anti-inflammatory properties, 5-chloro-6-methylpyridine-2-carbaldehyde has also shown promise in the field of antimicrobial research. A study conducted by researchers at the University of California, Los Angeles (UCLA) in 2020 reported that this compound effectively inhibits the growth of several pathogenic bacteria, including Staphylococcus aureus and Escherichia coli. The mechanism of action is believed to involve disruption of bacterial cell membranes, leading to cell death.

In the realm of cancer research, 5-chloro-6-methylpyridine-2-carbaldehyde has been investigated for its potential as an anticancer agent. A study published in Cancer Research in 2019 found that this compound selectively induces apoptosis in cancer cells while sparing normal cells. The mechanism underlying this selective toxicity is thought to involve the activation of caspase-dependent apoptotic pathways and the inhibition of cell cycle progression.

The synthetic accessibility of 5-chloro-6-methylpyridine-2-carbaldehyde further enhances its appeal as a starting material for drug discovery programs. Various synthetic routes have been developed to produce this compound efficiently and cost-effectively. One notable method involves the condensation of 5-chloro-6-methylpyridin-2(1H)-one with an appropriate aldehyde or ketone under mild conditions. This approach not only simplifies the synthesis but also allows for easy modification of the molecule to generate a diverse array of derivatives with enhanced biological activities.

The safety profile of 5-chloro-6-methylpyridine-2-carbaldehyde is another important consideration in its development as a therapeutic agent. Preclinical studies have generally shown that this compound is well-tolerated at therapeutic doses, with minimal toxicity observed in animal models. However, further investigations are needed to fully assess its safety and efficacy in humans.

In conclusion, 5-chloro-6-methylpyridine-2-carbaldehyde (CAS No. 137778-17-7) represents a promising lead compound with a wide range of potential applications in medicinal chemistry and pharmaceutical research. Its unique chemical structure and diverse biological activities make it an attractive target for further investigation and development into novel therapeutic agents. As research continues to advance, it is likely that new insights into the mechanisms and applications of this compound will emerge, paving the way for innovative treatments in various medical fields.

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