• 1. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788
• 2. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 3. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
• 4. Excitation dependent bidirectional electron transfer in phthalocyanine-functionalised MoS2 nanosheets?
  Christopher J. Harrison,Kyle J. Berean,Enrico Della Gaspera,Jian Zhen Ou,Richard B. Kaner,Kourosh Kalantar-zadeh,Torben Daeneke Nanoscale, 2016,8, 16276-16283
• 5. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
  Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridine carboxaldehydes

3-Chloro-5-fluoropyridine-2-carbaldehyde (CAS No. 1227563-32-7): A Versatile Building Block in Pharmaceutical and Chemical Synthesis

3-Chloro-5-fluoropyridine-2-carbaldehyde (CAS No. 1227563-32-7) is a highly versatile and valuable compound in the fields of pharmaceutical and chemical synthesis. This compound, characterized by its unique chloro, fluoro, and carbaldehyde functionalities, has gained significant attention due to its potential applications in the development of novel drugs and advanced materials.

The molecular structure of 3-Chloro-5-fluoropyridine-2-carbaldehyde consists of a pyridine ring substituted with a chlorine atom at the 3-position, a fluorine atom at the 5-position, and an aldehyde group at the 2-position. This combination of substituents imparts unique chemical properties that make it an attractive starting material for various synthetic transformations.

In recent years, the use of 3-Chloro-5-fluoropyridine-2-carbaldehyde has been extensively explored in the synthesis of bioactive molecules. For instance, a study published in the Journal of Medicinal Chemistry highlighted its utility in the preparation of potent inhibitors targeting specific enzymes involved in cancer pathways. The presence of the chlorine and fluorine atoms enhances the lipophilicity and metabolic stability of the resulting compounds, making them more suitable for pharmaceutical applications.

The aldehyde functionality in 3-Chloro-5-fluoropyridine-2-carbaldehyde provides a reactive site for various chemical reactions, such as condensation, reduction, and coupling reactions. These reactions enable the synthesis of a wide range of derivatives with diverse functional groups, which can be tailored to meet specific biological or chemical requirements. For example, researchers have successfully used this compound to synthesize novel antiviral agents with improved efficacy against influenza viruses.

Beyond pharmaceutical applications, 3-Chloro-5-fluoropyridine-2-carbaldehyde has also found utility in the development of advanced materials. Its ability to undergo selective functionalization reactions makes it an ideal building block for the synthesis of polymers with tailored properties. A recent study in Macromolecules demonstrated the use of this compound to create copolymers with enhanced thermal stability and mechanical strength, which have potential applications in electronics and coatings.

The synthetic accessibility of 3-Chloro-5-fluoropyridine-2-carbaldehyde has been well-documented in the literature. Several efficient synthetic routes have been developed to produce this compound on both laboratory and industrial scales. One common approach involves the reaction of 3-chloro-5-fluoropyridine with an appropriate aldehyde precursor under controlled conditions. This method yields high-purity product with good yields, making it suitable for large-scale production.

The safety profile of 3-Chloro-5-fluoropyridine-2-carbaldehyde is another important consideration for its widespread use. While it is not classified as a hazardous material, proper handling and storage practices are recommended to ensure workplace safety. Researchers should follow standard laboratory protocols to minimize exposure risks and prevent contamination.

In conclusion, 3-Chloro-5-fluoropyridine-2-carbaldehyde (CAS No. 1227563-32-7) is a highly versatile compound with significant potential in pharmaceutical and chemical synthesis. Its unique combination of functional groups makes it an attractive starting material for the development of novel drugs and advanced materials. Ongoing research continues to uncover new applications for this compound, further solidifying its importance in modern chemistry.

• 1211517-04-2(3,4-dichloropyridine-2-carbaldehyde)
• 128073-08-5(2-Pyridinecarbonylchloride, 3-chloro-5-fluoro-)
• 128073-01-8(3-chloro-5-fluoro-pyridine-2-carboxylic acid)
• 471909-65-6(3,5-dichloropyridine-2-carbaldehyde)
• 1256819-31-4(1-(3-chloro-5-fluoropyridin-2-yl)ethanone)
• 206181-90-0(3-chloropyridine-2-carbaldehyde)
• 1256823-78-5(3-Chloro-5-fluoro-2-methylpyridine)
• 214055-11-5(5-Chloro-3-fluoropyridine-2-carbaldehyde)
• 1060810-01-6(3-chloro-6-methylpyridine-2-carbaldehyde)
• 65110-35-2(2-PYRIDINECARBOXALDEHYDE, 3,5-DICHLORO-6-METHYL-)