- Microbial Transformation of 20(S)-Protopanaxatriol-Type Saponins by Absidia coeruleaChen, Guangtong; Yang, Min; Lu, Zhiqiang; Zhang, Jinqiang; Huang, Huilian; et al, Journal of Natural Products, 2007, 70(7), 1203-1206
Cas no 174721-08-5 (Ginsenoside Rh4)
Ginsenoside Rh4 is a rare protopanaxadiol-type saponin primarily isolated from Panax ginseng and related species. It exhibits notable pharmacological properties, including anti-inflammatory, antioxidant, and anticancer activities. Structurally characterized by a dammarane-type triterpenoid skeleton with sugar moieties, Rh4 demonstrates enhanced bioavailability compared to higher-molecular-weight ginsenosides due to its smaller glycosylation pattern. Research highlights its ability to modulate cellular signaling pathways such as NF-κB and MAPK, contributing to its chemopreventive potential. Additionally, Ginsenoside Rh4 shows neuroprotective effects by attenuating oxidative stress and mitochondrial dysfunction. Its low cytotoxicity and targeted action on tumor cells make it a promising candidate for adjuvant therapy in oncology and age-related diseases.
Ginsenoside Rh4 structure
Product Name:Ginsenoside Rh4
CAS No:174721-08-5
MF:C36H60O8
MW:620.856812477112
CID:823221
PubChem ID:21599928
Update Time:2025-07-02
Ginsenoside Rh4 Chemical and Physical Properties
Names and Identifiers
-
- Ginsenoside RH4
- Ginsenoside Rh(4)
- beta-D-glucopyranoside, (3beta,6alpha,12beta,20E)-3,12-dihydroxydammara-20(22),24-dien-6-yl
- (3beta,6alpha,12beta,20E)-3,12-Dihydroxydammara-20(22),24-dien-6-yl-beta-D-glucopyranoside
- (2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-Dihydroxy-4,4,8,10,14-pentamethyl-17-
- CHEBI:176255
- (2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-[(2E)-6-methylhepta-2,5-dien-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
- DTXSID001317113
- CHEMBL504029
- AKOS030526659
- AC-34672
- 174721-08-5
- FS-7833
- HY-N0905
- NCGC00485965-01
- MFCD22125012
- CS-3843
- (+)-Ginsenoside Rh4
- (2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-((2E)-6-methylhepta-2,5-dien-2-yl)-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-6-yl)oxy)-6-(hydroxymethyl)oxane-3,4,5-triol
- DA-63767
- (3beta,6alpha,12beta,20E)-3,12-Dihydroxydammara-20(22),24-dien-6-yl beta-D-glucopyranoside;
- 6-O-glucopyranosyldammar-20(22),24-diene-3,6,12-triol
- Ginsenoside Rh4
-
- MDL： MFCD22125012
- Inchi： 1S/C36H60O8/c1-19(2)10-9-11-20(3)21-12-15-35(7)27(21)22(38)16-25-34(6)14-13-26(39)33(4,5)31(34)23(17-36(25,35)8)43-32-30(42)29(41)28(40)24(18-37)44-32/h10-11,21-32,37-42H,9,12-18H2,1-8H3/b20-11+/t21-,22-,23+,24-,25-,26+,27+,28-,29+,30-,31+,32-,34-,35-,36-/m1/s1
- InChI Key： OZTXYFOXQFKYRP-TXRYYSRHSA-N
- SMILES： O([C@H]1[C@@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)O)[C@H]1C[C@@]2(C)[C@]3(C)CC[C@H](/C(=C/C/C=C(\C)/C)/C)[C@H]3[C@@H](C[C@@H]2[C@@]2(C)CC[C@@H](C(C)(C)[C@@H]21)O)O
Computed Properties
- Exact Mass: 620.42900
- Monoisotopic Mass: 620.42881887 g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 6
- Hydrogen Bond Acceptor Count: 8
- Heavy Atom Count: 44
- Rotatable Bond Count: 6
- Complexity: 1120
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 15
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 1
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 140
- Molecular Weight: 620.9
- XLogP3: 5.6
Experimental Properties
- Color/Form: Powder
- Density: 1.21
- Melting Point: No data available
- Boiling Point: 723.4±60.0 °C at 760 mmHg
- Flash Point: 391.3±32.9 °C
- Refractive Index: 1.579
- PSA: 139.84000
- LogP: 4.10080
Ginsenoside Rh4 Security Information
- Signal Word：warning
- Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
-
Warning Statement：
P264Thoroughly clean after treatment
P280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective mask
P305If it enters the eyes
P351Rinse carefully with water for a few minutes
P338Remove the contact lens(If any)And easy to operate,Continue flushing
P337If eye irritation persists
P313Obtain medical advice/care - Safety Instruction： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month
Ginsenoside Rh4 Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| DC Chemicals | DCR-035-20 mg |
Ginsenoside Rh(4) |
174721-08-5 | >98%, Standard References Grade | 20mg |
$280.0 | 2022-02-28 | |
| TRC | G410240-1mg |
Ginsenoside Rh4 |
174721-08-5 | 1mg |
$ 173.00 | 2023-09-07 | ||
| TRC | G410240-5mg |
Ginsenoside Rh4 |
174721-08-5 | 5mg |
$ 788.00 | 2023-09-07 | ||
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | G860635-5mg |
Ginsenoside Rh4 |
174721-08-5 | BR | 5mg |
￥5,744.70 | 2022-01-13 | |
| Chengdu Biopurify Phytochemicals Ltd | BP0670-10mg |
Ginsenoside Rh4 |
174721-08-5 | 98% | 10mg |
$260 | 2023-09-20 | |
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | G47350-20mg |
Ginsenoside Rh4 |
174721-08-5 | ,HPLC≥98% | 20mg |
￥2278.0 | 2023-09-07 | |
| WU HAN AN JIE KAI Biomedical Technology Co., Ltd. | ajce50238-5mg |
Ginsenoside Rh4 |
174721-08-5 | 98% | 5mg |
￥3476.00 | 2023-09-07 | |
| WU HAN AN JIE KAI Biomedical Technology Co., Ltd. | ajce50238-10mg |
Ginsenoside Rh4 |
174721-08-5 | 98% | 10mg |
￥4815.00 | 2023-09-07 | |
| SHANG HAI TAO SHU Biotechnology Co., Ltd. | T6S1485-5 mg |
Ginsenoside Rh4 |
174721-08-5 | 98.67% | 5mg |
￥3580.00 | 2022-04-26 | |
| ChemFaces | CFN92594-10mg |
Ginsenoside Rh4 |
174721-08-5 | >=98% | 10mg |
$368 | 2023-09-19 |
Ginsenoside Rh4 Production Method
Production Method 1
Reaction Conditions
1.1 Solvents: Ethanol , Water ; 4 d, 26 °C
Reference
Production Method 2
Reaction Conditions
1.1 Solvents: Ethanol , Water ; 4 d, 26 °C
Reference
Microbial Transformation of 20(S)-Protopanaxatriol-Type Saponins by Absidia coerulea
Chen, Guangtong; et al,
Journal of Natural Products,
2007,
70(7),
1203-1206
Production Method 3
Reaction Conditions
1.1 Solvents: Ethanol , Water ; 4 d, 26 °C
Reference
Microbial Transformation of 20(S)-Protopanaxatriol-Type Saponins by Absidia coerulea
Chen, Guangtong; et al,
Journal of Natural Products,
2007,
70(7),
1203-1206
Ginsenoside Rh4 Raw materials
Ginsenoside Rh4 Preparation Products
- Ginsenoside Rh1 (63223-86-9)
- (3β,6α,12β)-3,12,20,25-Tetrahydroxydammaran-6-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside (80928-46-7)
- sanchinoside-B1 (97744-96-2)
- (3β,6α,12β,20E)-3,12,25-Trihydroxydammar-20(22)-en-6-yl 2-O-β-D-xylopyranosyl-β-D-glucopyranoside (948046-16-0)
- 20(R)-Notoginsenoside R2 (948046-15-9)
- Ginsenoside Rh4 (174721-08-5)
- Notoginsenoside R2 (80418-25-3)
- Ginsenoside Rg2 (52286-74-5)
- (3beta,6alpha,12beta,20E)-3,12,25-Trihydroxydammar-20(22)-en-6-yl 2-O-6-deoxy-alpha-L-mannopyranosyl-beta-D-glucopyranoside (948046-19-3)
- (3β,6α,12β,20ξ)-3,12,20,25-Tetrahydroxydammaran-6-yl 2-O-β-D-xylopyranosyl-β-D-glucopyranoside (948046-18-2)
- (20R)-Ginsenoside Rh1 (80952-71-2)
- 20(R)-Ginsenoside Rg2 (80952-72-3)
- Ginsenoside F4 (181225-33-2)
Ginsenoside Rh4 Related Literature
-
Qiao Song,Angela Bamesberger,Lingyun Yang,Haley Houtwed,Haishi Cao Analyst, 2014,139, 3588-3592
-
Chung-Sung Yang,Mong-Shian Shih,Fang-Yi Chang New J. Chem., 2006,30, 729-735
-
Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
174721-08-5 (Ginsenoside Rh4) Related Products
- 142735-55-5(b-D-Galactopyranoside, (1b,3b,16b,22S)-1-(b-D-glucopyranosyloxy)-3,22-dihydroxycholest-5-en-16-yl(9CI))
- 147419-93-0(Ginsenoside Rg6)
- 100187-68-6(b-D-Glucopyranoside, (3b,6b)-5,6,16-trihydroxygrayanotox-9-en-3-yl (9CI))
- 142735-53-3(b-D-Galactopyranoside, (1b,3b,16b,22S)-1,3,22-trihydroxycholest-5-en-16-yl (9CI))
- 105558-26-7(Ginsenoside Rh3)
- 143815-99-0(b-D-Glucopyranoside, (3b,22E,24S)-stigmasta-5,22,25-trien-3-yl(9CI))
- 139953-19-8(Cholest-5-ene-3,16,22-triol; (3β,16β,22S)-form, 3-O-β-D-Glucopyranoside, 16-O-[α-L-rhamnopyranosyl-(1→3)-β-D-galactopyranoside])
- 126223-28-7(Ginsenoside Rg4)
- 186763-78-0(Ginsenoside Rg5)
- 26048-07-7(β-D-Galactopyranoside, (3β,20S)-3-hydroxypregn-5-en-20-yl O-β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranosyl-(1→2)-6-deoxy-3-O-methyl-)
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