Cas no 126223-28-7 (Ginsenoside Rg4)

Ginsenoside Rg4 is a bioactive saponin compound derived from Panax ginseng, known for its potential pharmacological properties. As a rare ginsenoside, it exhibits structural specificity due to its unique sugar moieties and aglycone core. Research suggests that Rg4 may contribute to modulating cellular signaling pathways, including anti-inflammatory and antioxidant mechanisms. Its lipophilic nature enhances membrane permeability, potentially improving bioavailability compared to polar ginsenosides. Preliminary studies indicate interactions with key metabolic enzymes and receptors, warranting further investigation into therapeutic applications. Analytical methods such as HPLC and LC-MS are typically employed for its quantification, ensuring high purity standards for research use. Rg4's stability profile under controlled conditions makes it suitable for in vitro and in vivo studies.
Ginsenoside Rg4 structure
Ginsenoside Rg4 structure
Product Name:Ginsenoside Rg4
CAS No:126223-28-7
MF:C42H70O12
MW:766.99801492691
CID:153519
PubChem ID:102004835
Update Time:2025-06-29

Ginsenoside Rg4 Chemical and Physical Properties

Names and Identifiers

    • b-D-Glucopyranoside, (3b,6a,12b,20Z)-3,12-dihydroxydammara-20(22),24-dien-6-yl 2-O-(6-deoxy-a-L-mannopyranosyl)-
    • Ginsenoside Rg4
    • (6β,8ξ,9ξ,12α,13α,14β,17β)-4-Ethyl-3,12-dihydroxy-4,10,14-trimeth yl-17-[(2Z)-6-methyl-2,5-heptadien-2-yl]gonan-6-yl 2-O-(6-deoxy-α -L-mannopyranosyl)-β-D-glucopyranoside
    • b-D-Glucopyranoside, (3b,6a,12b,20Z)-3,12-dihydroxydammara-20(22),24-dien-6-yl 2-O-(6-deoxy-a-...
    • (6beta,8xi,9xi,12alpha,13alpha,14beta,17beta)-17-[(1Z)-1,5-dimethylhexa-1,4-dien-1-yl]-4-ethyl-3,12-dihydroxy-4,10,14-trimethylgonan-6-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside
    • 3,6,12-Trihydroxydammar-10(22),24-diene-O-rhamnosyl-(1-2)-glucopyranoside
    • beta-D-Glucopyranoside, (3beta,6alpha,12beta,20Z)-3,12-dihydroxydammara-20(22),24-dien-6-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-
    • delta20-Ginsenoside Rg2
    • Ginsenoside F4
    • Ginsenosi Rg4
    • 2-[2-[[3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-[(2Z)-6-methylhepta-2,5-dien-2-yl]-2,3,5,6,7,9,11,1
    • (20E)-Ginsenoside F4
    • 126223-28-7
    • CHEBI:176310
    • FS-7062
    • (2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-[(2Z)-6-methylhepta-2,5-dien-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-6-methyloxane-3,4,5-triol
    • CS-0034276
    • HY-N6580
    • currency20(22)-Ginsenoside Rg6
    • AKOS037514667
    • 181225-33-2
    • DA-63766
    • 1ST185091
    • (2S,3R,4R,5R,6S)-2-((2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-((2Z)-6-methylhepta-2,5-dien-2-yl)-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-6-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl)oxy-6-methyloxane-3,4,5-triol
    • DA-53558
    • MDL： MFCD22200428
    • Inchi： 1S/C42H70O12/c1-20(2)11-10-12-21(3)23-13-16-41(8)29(23)24(44)17-27-40(7)15-14-28(45)39(5,6)36(40)25(18-42(27,41)9)52-38-35(33(49)31(47)26(19-43)53-38)54-37-34(50)32(48)30(46)22(4)51-37/h11-12,22-38,43-50H,10,13-19H2,1-9H3/b21-12-/t22-,23+,24+,25-,26+,27+,28-,29-,30-,31+,32+,33-,34+,35+,36-,37-,38+,40+,41+,42+/m0/s1
    • InChI Key： QOMBXPYXWGTFNR-KRPFXEAISA-N
    • SMILES： O([C@H]1[C@@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)O[C@H]1[C@@H]([C@@H]([C@H]([C@H](C)O1)O)O)O)[C@H]1C[C@@]2(C)[C@]3(C)CC[C@H](/C(=C\C/C=C(\C)/C)/C)[C@H]3[C@@H](C[C@@H]2[C@@]2(C)CC[C@@H](C(C)(C)[C@@H]21)O)O

Computed Properties

  • Exact Mass: 766.48700
  • Monoisotopic Mass: 766.48672766 g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 8
  • Hydrogen Bond Acceptor Count: 12
  • Heavy Atom Count: 54
  • Rotatable Bond Count: 8
  • Complexity: 1400
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 16
  • Undefined Atom Stereocenter Count : 5
  • Defined Bond Stereocenter Count: 1
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: 4.5
  • Topological Polar Surface Area: 199
  • Molecular Weight: 767.0

Experimental Properties

  • Color/Form: Powder
  • Density: 1.28±0.1 g/cm3 (20 oC 760 Torr),
  • Boiling Point: 860.2°Cat760mmHg
  • Flash Point: 474°C
  • Refractive Index: 1.591
  • Solubility: Insuluble (5.1E-4 g/L) (25 oC),
  • PSA: 198.76000
  • LogP: 2.95260

Ginsenoside Rg4 Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
MedChemExpress
HY-N6580-1mg
Ginsenoside Rg4
 126223-28-7 92.32%
1mg
 ￥3100 2024-04-20
MedChemExpress
HY-N6580-5mg
Ginsenoside Rg4
 126223-28-7 92.32%
5mg
 ￥6200 2024-04-20
ChemScence
CS-0034276-1mg
Ginsenoside Rg4
 126223-28-7
1mg
 $135.0 2022-04-28
ChemScence
CS-0034276-5mg
Ginsenoside Rg4
 126223-28-7
5mg
 $340.0 2022-04-28
TRC
G410260-1mg
20(Z)-Ginsenoside F4
 126223-28-7
1mg
 $552.00 2023-05-18
TRC
G410260-2.5mg
20(Z)-Ginsenoside F4
 126223-28-7
2.5mg
 $1103.00 2023-05-18
SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd.
G42760-10mg
(6β,8ξ,9ξ,12α,13α,14β,17β)-4-Ethyl-3,12-dihydroxy-4,10,14-trimeth yl-17-[(2Z)-6-methyl-2,5-heptadien-2-yl]gonan-6-yl 2-O-(6-deoxy-α -L-mannopyranosyl)-β-D-glucopyranoside
 126223-28-7 ,HPLC≥98%
10mg
 ￥2948.0 2023-09-07
SHANG HAI TAO SHU Biotechnology Co., Ltd.
TN1686-5 mg
Ginsenoside Rg4
 126223-28-7
5mg
 ￥2987.00 2022-04-26
SHANG HAI TAO SHU Biotechnology Co., Ltd.
TN1686-10 mg
Ginsenoside Rg4
 126223-28-7
10mg
 ￥4480.00 2022-04-26
SHANG HAI TAO SHU Biotechnology Co., Ltd.
TN1686-25 mg
Ginsenoside Rg4
 126223-28-7
25mg
 ￥7987.00 2022-04-26

Ginsenoside Rg4 Suppliers

Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:126223-28-7)Ginsenoside Rg4
Order Number:A1200223
Stock Status:in Stock
Quantity:1mg/5mg/10mg
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 02:41
Price ($):389.0/777.0/1241.0

Ginsenoside Rg4 Related Literature

Related Categories

Additional information on Ginsenoside Rg4

Comprehensive Overview of Ginsenoside Rg4 (CAS No. 126223-28-7): Properties, Benefits, and Applications

Ginsenoside Rg4, a bioactive compound derived from Panax ginseng, has garnered significant attention in recent years due to its potential health benefits. With the CAS registry number 126223-28-7, this saponin is classified as a protopanaxadiol-type ginsenoside, a subgroup known for its pharmacological activities. Researchers and health enthusiasts alike are increasingly interested in Ginsenoside Rg4 for its anti-inflammatory, antioxidant, and neuroprotective properties, making it a focal point in modern nutraceutical and pharmaceutical research.

The rise of natural supplements and plant-derived therapeutics has propelled Ginsenoside Rg4 into the spotlight. As consumers seek alternatives to synthetic drugs, compounds like Ginsenoside Rg4 offer a promising avenue for supporting overall wellness. Studies suggest its potential role in metabolic regulation, immune modulation, and even anti-aging effects, aligning with current trends in preventive healthcare and longevity science.

One of the most searched questions regarding Ginsenoside Rg4 is its comparison to other ginsenosides, such as Rg1, Rb1, or Rg3. While structurally similar, Ginsenoside Rg4 exhibits unique bioavailability and mechanistic pathways. For instance, its low molecular weight and enhanced membrane permeability may contribute to superior absorption in the human body, a topic frequently explored in pharmacokinetic studies.

In the realm of skincare, Ginsenoside Rg4 has emerged as a sought-after ingredient due to its collagen-stimulating and UV-protective effects. With the growing demand for clean beauty products, cosmetic formulations incorporating Ginsenoside Rg4 are gaining traction. Its ability to mitigate oxidative stress and promote skin barrier function addresses common concerns like premature aging and hyperpigmentation.

Another hot topic is the role of Ginsenoside Rg4 in gut microbiota modulation. Recent studies highlight its prebiotic-like effects, fostering the growth of beneficial bacteria while inhibiting pathogenic strains. This aligns with the booming interest in gut-brain axis research and the use of natural compounds for digestive health optimization.

From a technical perspective, the extraction and purification of Ginsenoside Rg4 (CAS 126223-28-7) involve advanced techniques like high-performance liquid chromatography (HPLC) and supercritical fluid extraction. These methods ensure high purity, a critical factor for research-grade compounds and therapeutic applications. The compound’s stability under varying pH and temperature conditions also makes it suitable for diverse formulation strategies.

As the scientific community continues to unravel the mechanisms of Ginsenoside Rg4, its potential applications expand. Whether in functional foods, dietary supplements, or targeted therapies, this ginsenoside exemplifies the convergence of traditional medicine and modern science. With rigorous clinical trials underway, Ginsenoside Rg4 may soon redefine standards in natural product-based interventions.

126223-28-7 (Ginsenoside Rg4) Related Products

Recommended suppliers
Amadis Chemical Company Limited
(CAS:126223-28-7)Ginsenoside Rg4
A1200223
Purity:99%/99%/99%
Quantity:1mg/5mg/10mg
Price ($):389.0/777.0/1241.0
Email