Production Method 1

288-32-4

22256-98-0

58-97-9

61-19-8

21138-49-8

1548523-54-1

916981-64-1

1548523-33-6

1548523-97-2

1548524-02-2

1548524-11-3

1548524-26-0

1548523-22-3

1548618-15-0

1548523-82-5

1548523-86-9

1548618-19-4

1548524-07-7

1548524-22-6

1548618-21-8

Reaction Conditions

1.1R:2-PySSPy-2, R:Et3N, R:PPh3, S:DMF, S:DMSO, 3 h, rt
1.1R:2-PySSPy-2, R:Et3N, R:PPh3, S:DMF, S:DMSO, 3 h, rt
1.1R:2-PySSPy-2, R:Et3N, R:PPh3, S:DMF, S:DMSO, 3 h, rt
1.1R:2-PySSPy-2, R:Et3N, R:PPh3, S:DMF, S:DMSO, 3 h, rt
2.1S:H2O, 3 d, 25°C, pH 7

Reference

Progress in demonstrating homochiral selection in prebiotic RNA synthesis

By Joshi, Prakash C. et al, Advances in Space Research, 2013, 51(5), 772-779

Raw materials

• Imidazole
• [5']uridylic acid
• Uridine 5'-Monophosphate
• Adenosine monophosphate
• 9-(5-O-Phosphono-β-L-ribofuranosyl)-9H-purin-6-amine

Preparation Products

• β-L-Adenosine, 5'-O-phosphono-β-L-adenylyl-(2'→5')- (916981-64-1)
• β-L-Uridine, 5'-O-phosphonoadenylyl-(2'→5')-, sodium salt (1:1) (1548523-33-6)
• (1548523-97-2)
• (1548524-02-2)
• Uridine, 5'-O-phosphono-β-L-adenylyl-(3'→5')- (1548524-11-3)
• Adenosine, 5'-O-phosphono-β-L-adenylyl-(3'→5')- (1548524-26-0)
• (1548523-22-3)
• (1548618-15-0)
• (1548523-82-5)
• (1548523-86-9)
• β-L-Uridine, 5'-O-phosphono-β-L-uridylyl-(3'→5')- (1548618-19-4)
• β-L-Uridine, 5'-O-phosphono-β-L-adenylyl-(3'→5')- (1548524-07-7)
• β-L-Adenosine, 5'-O-phosphono-β-L-adenylyl-(3'→5')- (1548524-22-6)
• (1548523-54-1)
• Uridine, 5'-O-phosphono-β-L-uridylyl-(3'→5')- (1548618-21-8)

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