Cas no 61-19-8 (Adenosine monophosphate)

Adenosine monophosphate (AMP) is a nucleotide composed of adenine, ribose, and a single phosphate group. It plays a critical role in cellular energy metabolism as an intermediate in the synthesis and degradation of ATP. AMP is widely utilized in biochemical research, particularly in studies involving energy transfer, signal transduction, and enzymatic processes. Its high purity and stability make it suitable for applications in molecular biology, diagnostics, and pharmaceutical development. AMP also serves as a precursor for cyclic AMP (cAMP), an important secondary messenger in cellular signaling pathways. The compound is available in various forms, including disodium salt, to enhance solubility and compatibility with experimental protocols.
Adenosine monophosphate structure
Adenosine monophosphate structure
Product Name:Adenosine monophosphate
CAS No:61-19-8
MF:C10H14N5O7P
MW:347.2212
MDL:MFCD00005750
CID:33768
PubChem ID:6083
Update Time:2025-10-14

Adenosine monophosphate Chemical and Physical Properties

Names and Identifiers

    • Adenosine 5'-monophosphate
    • Adenylic acid~5-AMP
    • Adenosine-5-monophosphoric acid
    • AMP
    • adenosine phosphate
    • 2,2,4-Trichloroacetophenone
    • 5-Adenylic acid
    • Adenosine-5'-monophosphate
    • Adenosine 5-monophosphate
    • 5-AMP
    • a5mp
    • adenosine,mono(dihydrogenphosphate)(ester)
    • adenosine5’-phosphate
    • adenovite
    • adenyl
    • amp(nucleotide)
    • amp[nucleotide]
    • cardiomone
    • 5'-ADENOSINE MONOPHOSPHATE
    • 5'-Adenylic Acid
    • adenosine-5'-monophosphoric acid
    • Ado-5'-P
    • lycedan
    • my-b-den
    • myoston
    • phosaden
    • Adenosine 5′-monophosphate
    • 5'-AMP
    • Adenosine monophosphate
    • adenylic acid
    • adenosine 5'-phosphate
    • Phosphaden
    • adenylate
    • Phosphentaside
    • Vitamin B8
    • Ergadenylic acid
    • Monophosphadenine
    • Muscle adenylic acid
    • Muskeladenylsaeure
    • AMP (nucleotide)
    • Adenosine 5'-(dihydrogen phosphate)
    • Adenosine 5'-phosphoric acid
    • Adenosini phosphas
    • Adenosine-5-monophosphor
    • Adenosine-5’-phosphoric acid
    • Adenosine-5'-monophosphoricacid
    • Ado5'P
    • AMP dianion
    • adenosine-5'P
    • Adenosine-5-monophosphate(2-)
    • pA
    • PAdo
    • 5'-O-phosphonoadenosine
    • Adenosine phosphate Adenosine Phosphate AMP A 5MP 5'-AMP Lycedan Phosaden My-B-Den Adenovite Cardiomone
    • AMP(2-)
    • Adenosine-5-monophosphate dianion
    • [(2R,3S,4R,5R)-5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate;hydrate
    • SCHEMBL18287224
    • CCG-267996
    • NSC-20264
    • Adenosine 5 -monophosphate
    • adenosin-5'-monophosphat
    • adenosine-monophosphate
    • UNII-415SHH325A
    • 1ua4
    • CAS-61-19-8
    • F20323
    • AMP (VAN)
    • 5'-ADENYLIC ACID [FCC]
    • bmse000005
    • Adenosine 5'-monophosphoric acid
    • 136920-07-5
    • Adenosine-5'-Monophosphate, Free acid
    • Prestwick1_000356
    • Muscle adenylate
    • Epitope ID:137353
    • NSC 20264
    • DB-022416
    • Adenosine phosphate(Vitamin B8)
    • 1pyg
    • 61-19-8
    • 5'-Phosphate, Adenosine
    • AKOS015833068
    • bmse000992
    • 7A8E6D15-9136-44C1-88C9-E1A224638E56
    • [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
    • Adenosine 5'-monophosphate-Agarose, lyophilized powder
    • BRN 0054612
    • Adenosine, mono(dihydrogen phosphate) (ester)
    • A 5MP
    • T-ADENYLIC
    • 5'-ADENYLIC ACID [USP-RS]
    • s9366
    • Phosphate d'adenosine (INN-French)
    • adenosine 5'-phosphates
    • Adenosini phosphas (INN-Latin)
    • ADENOSINE PHOSPHATE (MART.)
    • ADENOSINE PHOSPHATE [HSDB]
    • [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate
    • Adenylic acid (VAN)
    • ADENOSINE 5'-(DIHYDROGEN PHOSPHATE).
    • D02769
    • ((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate
    • J-700145
    • Q318369
    • adenosina fosfato
    • BPBio1_000497
    • CHEBI:37096
    • BDBM18137
    • 53624-78-5
    • Adenosine phosphate [USAN:BAN:INN]
    • Adenosine5'-monophosphate
    • [3h]adenosine 5'-monophosphate
    • NCGC00163319-02
    • C00020
    • Adenosine Monophosphate (Amp)
    • 4-26-00-03615 (Beilstein Handbook Reference)
    • CHEBI:16027
    • NCGC00163319-03
    • Adenosine 5'-monophosphate-Agarose, saline suspension
    • Fosfato de adenosina
    • NCGC00163319-01
    • Adenosine phosphate (USAN/INN)
    • DB00131
    • [(2R,3S,4R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-2-oxolanyl]methyl dihydrogen phosphate
    • Prestwick0_000356
    • 5'-adenylate
    • 1z6s
    • 5'-ADENYLIC ACID [MI]
    • 2gsu
    • ADENOSINE PHOSPHATE [USAN]
    • ADENOSINE PHOSPHATE [MART.]
    • MFCD00149360
    • 9H-purin-6-amine, 9-(5-O-phosphono-beta-D-ribofuranosyl)-
    • NSC20264
    • Adenyl (TN)
    • Phosphate d'adenosine [INN-French]
    • Prestwick3_000356
    • Adenosine phosphate [USAN:INN:BAN]
    • Adenosine 5monophosphate
    • Tox21_112046
    • Adenosini phosphas [INN-Latin]
    • SCHEMBL5588
    • 415SHH325A
    • 5'adenylic acid
    • {[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
    • 5'-ADENYLIC ACID (USP-RS)
    • Fosfato de adenosina [INN-Spanish]
    • Phosphate d'adenosine
    • bmse000873
    • BSPBio_000451
    • DTXCID002560
    • AKOS015888563
    • A0158
    • adenosine-phosphate
    • Adenosine-5-monophosphorate
    • CS-0017523
    • 67583-85-1
    • Prestwick2_000356
    • ADENOSINE PHOSPHATE [VANDF]
    • SPBio_002372
    • W-105182
    • ADENOSINE PHOSPHATE [INN]
    • Tox21_112046_1
    • AS-11783
    • 9H-Purin-6-amine, 9-(5-O-phosphono-.beta.-D-ribofuranosyl)-
    • BP-58695
    • Adenosine-5-phosphate
    • GTPL2455
    • HY-A0181
    • Adenosine 5'-phosphorate
    • 7gpb
    • EN300-1700412
    • Z2216887941
    • Adenosine 5'-monophosphate-Agarose, lyophilized powder, Contains lactose stabilizers that must be removed prior to use.
    • CHEMBL752
    • DTXSID5022560
    • a-5mp
    • 122768-03-0
    • Adenosine-5'-monophosphorate
    • Adenosine 5' monophosphate
    • EINECS 200-500-0
    • Muskeladenosin-phosphorsaeure
    • Adenosine 5' Phosphate
    • C01EB10
    • HSDB 3281
    • My-beta-Den
    • Adenosine-3(+2')-monophosphoric acid monohydrate*
    • Fosfato de adenosina (INN-Spanish)
    • CHEBI:22256
    • ADENOSINE PHOSPHATE [WHO-DD]
    • MFCD00005750
    • 8gpb
    • MDL： MFCD00005750
    • Inchi： 1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
    • InChI Key： UDMBCSSLTHHNCD-KQYNXXCUSA-N
    • SMILES： P(=O)(O[H])(O[H])OC([H])([H])[C@]1([H])[C@]([H])([C@]([H])([C@]([H])(N2C([H])=NC3=C(N([H])[H])N=C([H])N=C23)O1)O[H])O[H]

Computed Properties

  • Exact Mass: 347.06300
  • Monoisotopic Mass: 347.063084
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 5
  • Hydrogen Bond Acceptor Count: 11
  • Heavy Atom Count: 23
  • Rotatable Bond Count: 4
  • Complexity: 481
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 4
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 3
  • XLogP3: -3.5
  • Topological Polar Surface Area: 186

Experimental Properties

  • Color/Form: Powder
  • Density: 2.32
  • Melting Point: 178-185 oC
  • Boiling Point: 798.5°C at 760 mmHg
  • Flash Point: 436.728°C
  • Solubility: H2O: with addition of mild alkalisoluble
  • Water Partition Coefficient: Soluble in water.
  • PSA: 195.88000
  • LogP: -1.28180
  • Merck: 158
  • pka: 3.8, 6.2(at 25℃)
  • Specific Rotation: -45.0° - -50.0° (c=2, 1mol/L NaOH)
  • Sensitiveness: Sensitive to humidity and light

Adenosine monophosphate Security Information

Adenosine monophosphate Customs Data

  • HS CODE：2934999090
  • Customs Data：

    China Customs Code:

    2934999090

    Overview:

    2934999090. Other heterocyclic compounds. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Adenosine monophosphate Production Method

Production Method 1

Reaction Conditions
1.1C:1H-Imidazole, S:H2O, 10 min, rt
Reference
A simple and efficient method to prepare thio-esters in aqueous solutions
By Coleman, Tricia M. et al, Tetrahedron Letters, 2005, 46(25), 4307-4310

Production Method 2

Reaction Conditions
1.1R:NaOD, C:1801427-51-9, S:D2O, 37°C, pH 7.4
Reference
Intrinsic Apyrase-Like Activity of Cerium-Based Metal-Organic Frameworks (MOFs): Dephosphorylation of Adenosine Tri- and Diphosphate
By Yang, Jian et al, Angewandte Chemie, 2020, 59(51), 22952-22956

Production Method 3

Reaction Conditions
1.1R:4-Ethylmorpholine, C:Pb(NO3)2, S:H2O, 1 d, 20°C, pH 7.3
Reference
Chiral Selection in Oligoadenylate Formation in the Presence of a Metal ion Catalyst or Poly(U) Template
By Osawa, Kazuomi et al, Origins of Life and Evolution of Biospheres, 2005, 35(3), 213-223

Production Method 4

Reaction Conditions
1.1R:PO43-, R:H2O, 2 h, 150°C
Reference
Confinement and Time Immemorial: Prebiotic Synthesis of Nucleotides on a Porous Mineral Nanoreactor
By Rodrigues, Francisco et al, Journal of Physical Chemistry Letters, 2019, 10(15), 4192-4196

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Adenosine monophosphate Spectrogram

13C NMR
13C NMR
1H NMR 300 MHz DMSO
1H NMR

Adenosine monophosphate Related Literature

Related Categories

Additional information on Adenosine monophosphate

Adenosine Monophosphate (AMP) - CAS No. 61-19-8: A Comprehensive Overview

Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide that plays a crucial role in various biological processes. With the Chemical Abstracts Service (CAS) number 61-19-8, AMP is a fundamental component of cellular metabolism and signaling pathways. This comprehensive overview delves into the chemical structure, biological functions, and recent research advancements related to AMP.

Chemical Structure and Properties

AMP is composed of an adenine base, a ribose sugar, and a single phosphate group. The molecular formula of AMP is C10H14N5O7P, and its molecular weight is approximately 347.22 g/mol. The compound is highly soluble in water and exists as a white crystalline powder. The presence of the adenine base and ribose sugar makes AMP a key building block for RNA synthesis, while the phosphate group facilitates its involvement in energy transfer and signaling processes.

Biological Functions

One of the primary functions of AMP is its role in energy metabolism. It serves as an intermediate in the ATP-ADP cycle, which is essential for maintaining cellular energy homeostasis. When ATP (adenosine triphosphate) is hydrolyzed to ADP (adenosine diphosphate) and subsequently to AMP, it releases energy that powers various cellular activities. Additionally, AMP can be converted back to ATP through the action of enzymes such as adenylate kinase.

Beyond its role in energy metabolism, AMP is also involved in several signaling pathways. For instance, it activates the enzyme adenosine monophosphate-activated protein kinase (AMPK), which acts as a metabolic master switch. AMPK responds to low energy levels by promoting catabolic processes that generate ATP and inhibiting anabolic processes that consume ATP. This regulatory mechanism helps maintain cellular energy balance and is crucial for cell survival under stress conditions.

Recent Research Advancements

In recent years, significant research has been conducted to explore the therapeutic potential of AMP and its derivatives. One notable area of focus is the use of AMP analogs as potential treatments for metabolic disorders such as diabetes and obesity. Studies have shown that activating AMPK through pharmacological means can improve insulin sensitivity and reduce fat accumulation, making it a promising target for drug development.

Another area of interest is the role of AMP in neurodegenerative diseases. Research has indicated that dysregulation of AMPK activity may contribute to the pathogenesis of conditions such as Alzheimer's disease and Parkinson's disease. By modulating AMPK activity, it may be possible to mitigate some of the neurodegenerative processes associated with these diseases.

Clinical Applications

The clinical applications of AMP are diverse and continue to expand with ongoing research. In addition to its potential in metabolic disorders and neurodegenerative diseases, AMP has been explored for its anti-inflammatory properties. Studies have demonstrated that activating AMPK can reduce inflammation by inhibiting the production of pro-inflammatory cytokines and chemokines.

Furthermore, AMP has been investigated for its potential in cancer therapy. Some studies have shown that activating AMPK can inhibit cancer cell proliferation by suppressing mTOR signaling, a key pathway involved in cell growth and survival. This makes AMPK activation a potential strategy for enhancing the efficacy of existing cancer treatments.

Conclusion

In conclusion, adenosine monophosphate (AMP) with CAS number 61-19-8 is a multifaceted molecule with critical roles in cellular metabolism, signaling pathways, and various therapeutic applications. Its involvement in energy homeostasis, metabolic regulation, neuroprotection, anti-inflammatory responses, and cancer therapy highlights its significance in both basic research and clinical settings. As ongoing research continues to uncover new insights into the functions and applications of AMP, it remains an important focus for scientists and clinicians alike.

61-19-8 (Adenosine monophosphate) Related Products

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NewCan Biotech Limited
(CAS:61-19-8)Adenosine 5'-monophosphate
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(CAS:61-19-8)Adenosine monophosphate
A833090
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Quantity:1kg
Price ($):247.0
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