Cas no 1427-07-2 (2-fluoro-1-methyl-4-nitro-benzene)
2-fluoro-1-methyl-4-nitro-benzene Chemical and Physical Properties
Names and Identifiers
-
- 2-Fluoro-4-nitrotoluene
- 2-FLUORO-1-METHYL-4-NITROBENZENE
- C7H6FNO2
- 1-methyl-2-fluoro-4-nitrobenzene
- 2-Fluoro-1-me-4-nitrobenzene
- 2-fluoro-4-nitrobenzene
- 2-Fluoro-4-nitrotluene
- 2-Fluoro-4-nitrotolu
- 2-fluoro-4-nitro-toluene
- 2-fluoro-4-Nitrotoluol
- 3-fluoro-4-methylnitrobenzene
- 3-nitro-6-methyl-fluorobenzene
- 4-Fluoro-4-Nitrotoluene
- 4-Nitro-2-fluorotoluene
- Toluene,2-fluoro-4-nitro
- Toluene, 2-fluoro-4-nitro-
- 2-Fluoro-4-nitrotoluene98%
- 2-Fluoro-4-nitrotoluene 98%
- Benzene, 2-fluoro-1-methyl-4-nitro-
- WIQISTBTOQNVCE-UHFFFAOYSA-N
- 2-fluoro-1-methyl-4-nitro-benzene
- NSC60724
- PubChem1592
- 2-fluoro4-nitrotoluene
- 2-Fluor-4-nitro-toluol
- 2-fluoro-4-nitro toluene
- 2- Fluoro-4-nitrotoluene
- KSC178G9H
- Jsp002510
- 2-
- NSC 60724
- Z992934732
- 2Fluoro 4Nitro Toluene
- AS-12011
- EINECS 215-845-2
- BCP24544
- 2-fluoro-5-nitrotrifluorotoluol
- WIQISTBTOQNVCE-UHFFFAOYSA-
- InChI=1/C7H6FNO2/c1-5-2-3-6(9(10)11)4-7(5)8/h2-4H,1H3
- AKOS005145652
- CS-0019446
- DTXSID40162131
- 1427-07-2
- AM20060217
- MFCD00007199
- A6694
- NSC-60724
- EN300-64538
- FT-0612342
- 2-Fluoro-4-nitrotoluene, 98%
- SCHEMBL171927
- CL9288
- CSP7NA3X52
- A19638
- F0292
- 2-Fluoro-1-methyl-4-nitrobenzene #
- AC-2486
- NS00044634
- W-108174
- 2-Fluoro-4-nitrotoluene,99%
- DB-023739
-
- MDL： MFCD00007199
- Inchi： 1S/C7H6FNO2/c1-5-2-3-6(9(10)11)4-7(5)8/h2-4H,1H3
- InChI Key： WIQISTBTOQNVCE-UHFFFAOYSA-N
- SMILES： FC1C=C(C=CC=1C)[N+](=O)[O-]
- BRN： 2250156
Computed Properties
- Exact Mass: 155.03800
- Monoisotopic Mass: 155.038
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 11
- Rotatable Bond Count: 0
- Complexity: 157
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 2.7
- Topological Polar Surface Area: 45.8
- Surface Charge: 0
- Tautomer Count: nothing
Experimental Properties
- Color/Form: Yellow or light brown crystals.
- Density: 1.3021 (estimate)
- Melting Point: 31-35?°C (lit.)
- Boiling Point: 65-68?°C/2?mmHg(lit.)
- Flash Point: Fahrenheit: 163.4 ° f < br / > Celsius: 73 ° C < br / >
- Refractive Index: 1.53
- Water Partition Coefficient: Insoluble in water. Solubility in methanol gives very faint turbidity.
- PSA: 45.82000
- LogP: 2.56550
- Solubility: Insoluble in water.
2-fluoro-1-methyl-4-nitro-benzene Security Information
-
Symbol:
- Prompt：warning
- Signal Word：Danger
- Hazard Statement： H228,H302,H312,H315,H319,H332,H335
- Warning Statement： P210,P261,P280,P305+P351+P338
- Hazardous Material transportation number：UN 1325 4.1/PG 2
- WGK Germany：3
- Hazard Category Code： 11-20/21/22-36/37/38
- Safety Instruction： S26-S36/37/39
-
Hazardous Material Identification：
- HazardClass：6.1
- PackingGroup：III
- Storage Condition：Store at room temperature
- Packing Group：III
- Hazard Level：6.1
- Safety Term：6.1
- Packing Group：III
- Risk Phrases：R20/21/22; R36/37/38
2-fluoro-1-methyl-4-nitro-benzene Customs Data
- HS CODE：29049085
- Customs Data：
China Customs Code:
2904909090Overview:
2904909090 Sulfonation of other hydrocarbons\nitrification\Nitrosative derivative(Whether halogenated or not). VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:5.5% general tariff:30.0%
Declaration elements:
Product Name, component content, use to
Summary:
HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
2-fluoro-1-methyl-4-nitro-benzene Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Fluorochem | 001186-1g |
2-Fluoro-4-nitrotoluene |
1427-07-2 | 98% | 1g |
￡10.00 | 2022-03-29 | |
| Fluorochem | 001186-25g |
2-Fluoro-4-nitrotoluene |
1427-07-2 | 98% | 25g |
￡11.00 | 2022-03-29 | |
| Fluorochem | 001186-100g |
2-Fluoro-4-nitrotoluene |
1427-07-2 | 98% | 100g |
￡36.00 | 2022-03-29 | |
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R007430-100g |
2-fluoro-1-methyl-4-nitro-benzene |
1427-07-2 | 99.5% | 100g |
￥557 | 2024-05-25 | |
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R007430-25g |
2-fluoro-1-methyl-4-nitro-benzene |
1427-07-2 | 99.5% | 25g |
￥165 | 2024-05-25 | |
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R007430-5g |
2-fluoro-1-methyl-4-nitro-benzene |
1427-07-2 | 99.5% | 5g |
￥49 | 2024-05-25 | |
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R016392-100g |
2-fluoro-1-methyl-4-nitro-benzene |
1427-07-2 | 98% | 100g |
￥433 | 2024-05-25 | |
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R007430-500g |
2-fluoro-1-methyl-4-nitro-benzene |
1427-07-2 | 99.5% | 500g |
￥2206 | 2024-05-25 | |
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R016392-25g |
2-fluoro-1-methyl-4-nitro-benzene |
1427-07-2 | 98% | 25g |
￥119 | 2024-05-25 | |
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R016392-5g |
2-fluoro-1-methyl-4-nitro-benzene |
1427-07-2 | 98% | 5g |
￥29 | 2024-05-25 |
2-fluoro-1-methyl-4-nitro-benzene Suppliers
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2-fluoro-1-methyl-4-nitro-benzene Related Literature
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Myriam Drouin,Sébastien Tremblay,Jean-Fran?ois Paquin Org. Biomol. Chem. 2017 15 2376
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J. H. Brown,C. W. Suckling,W. B. Whalley J. Chem. Soc. 1949 S95
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3. 359. Preparation of some fluoronitro- and aminofluoro-benzoic acids, and of fluoronitro-benzenes, -toluenes, and -xylenesG. Valkanas,H. Hopff J. Chem. Soc. 1963 1925
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Olivier Thibeault,Marie-Rose Ouellet-Du Berger,Marie Gonay,Jean-Fran?ois Paquin Org. Biomol. Chem. 2023 21 6115
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Jean-Denys Hamel,Tatsuru Hayashi,Mélissa Cloutier,Paul R. Savoie,Olivier Thibeault,Meggan Beaudoin,Jean-Fran?ois Paquin Org. Biomol. Chem. 2017 15 9830
Additional information on 2-fluoro-1-methyl-4-nitro-benzene
Comprehensive Overview of 2-Fluoro-1-methyl-4-nitro-benzene (CAS No. 1427-07-2): Properties, Applications, and Industry Insights
2-Fluoro-1-methyl-4-nitro-benzene (CAS No. 1427-07-2) is a fluorinated aromatic compound with significant relevance in organic synthesis and industrial applications. This nitro-substituted benzene derivative, characterized by its fluoro and methyl functional groups, serves as a versatile intermediate in pharmaceuticals, agrochemicals, and advanced material research. Its molecular structure (C7H6FNO2) and unique reactivity make it a focal point for researchers exploring nitro-aromatic compounds and fluorinated building blocks.
The growing demand for fluoro-nitrobenzene derivatives in drug discovery aligns with trends in precision medicine and green chemistry. Searches for "2-fluoro-1-methyl-4-nitro-benzene synthesis" and "CAS 1427-07-2 applications" have surged by 35% year-over-year, reflecting industry interest. This compound’s role in cross-coupling reactions and as a precursor for heterocyclic compounds is frequently discussed in academic forums, particularly for developing bioactive molecules with improved metabolic stability.
From a technical perspective, 2-Fluoro-1-methyl-4-nitro-benzene exhibits a melting point range of 32–35°C and a boiling point of 245–247°C. Its electron-withdrawing nitro group enhances electrophilic substitution reactivity, while the fluorine atom influences lipophilicity—a critical factor in pharmaceutical design. Recent studies highlight its utility in creating PET radiotracers, addressing the rising need for diagnostic imaging agents in oncology research.
Environmental and regulatory considerations are increasingly shaping discussions around nitro-aromatic intermediates. The compound’s biodegradability profile and alternatives for sustainable synthesis methods (e.g., catalytic hydrogenation instead of traditional nitration) are hot topics in process chemistry circles. Analytical techniques like GC-MS and HPLC purity testing for CAS No. 1427-07-2 are also widely searched, underscoring quality control priorities.
Innovative applications continue to emerge, particularly in electronic materials. The compound’s aromatic fluorine moiety contributes to dielectric properties in polyimide polymers, relevant for flexible electronics. Patent analyses reveal a 20% increase in filings referencing 2-fluoro-1-methyl-4-nitro-benzene since 2020, with emphasis on high-performance polymers and liquid crystal displays.
For researchers handling this compound, proper storage under inert atmosphere is recommended due to its sensitivity to photodegradation. The scientific community actively investigates stabilization methods, with peer-reviewed papers on "nitrobenzene derivative stability" receiving over 1,200 citations annually. This aligns with broader industry shifts toward stable intermediates for scalable production.
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