Highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides?
Organic & Biomolecular Chemistry Pub Date: 2017-11-13 DOI: 10.1039/C7OB02406A
Abstract
Herein, we report a highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides. Not only does this transformation provide access to versatile fluorinated building blocks that were difficult or hardly possible to access beforehand, but it also represents a rare case of a highly regioselective gold-catalyzed hydroalkoxylation of internal alkynes and puts forward the utility of the difluoromethylene unit as a directing group in catalysis.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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