Production Method 1

86087-23-2

915095-85-1

106-39-8

915095-84-0

456-22-4

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide Solvents: Tetrahydrofuran ;  30 min, < 10 °C; 30 min, 7 - 10 °C
1.2 Solvents: Water

Reference

Efficient Synthesis of Empagliflozin, an Inhibitor of SGLT-2, Utilizing an AlCl3-Promoted Silane Reduction of a β-Glycopyranoside

Wang, Xiao-jun; Zhang, Li; Byrne, Denis; Nummy, Larry; Weber, Dirk; et al, Organic Letters, 2014, 16(16), 4090-4093

4-Chlorobromobenzene Raw materials

• (S)-Tetrahydrofuran-3-ol
• (5-Bromo-2-chlorophenyl)(4-fluorophenyl)methanone

4-Chlorobromobenzene Preparation Products

• (S)-(5-Bromo-2-chlorophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone (915095-84-0)
• 4-Chlorobromobenzene (106-39-8)
• 4-Fluorobenzoic acid (456-22-4)

• 1. Synthesis of optically pure (S)-2-amino-5-arylpent-4-ynoic acids by Sonogashira reactions and their potential use as highly selective potent inhibitors of aldose reductase
  Silvio Parpart,Andranik Petrosyan,Syed Jawad Ali Shah,Raji Akeem Adewale,Peter Ehlers,Tatevik Grigoryan,Anna F. Mkrtchyan,Zorayr Z. Mardiyan,Ani J. Karapetyan,Avetis H. Tsaturyan,Ashot S. Saghyan,Jamshed Iqbal,Peter Langer RSC Adv. 2015 5 107400
• 2. Effective modulation of the photoluminescence properties of 2,1,3-benzothiadiazoles and 2,1,3-benzoselenadiazoles by Pd-catalyzed C–H bond arylations
  Imane Idris,Thibault Tannoux,Fazia Derridj,Vincent Dorcet,Julien Boixel,Veronique Guerchais,Jean-Fran?ois Soulé,Henri Doucet J. Mater. Chem. C 2018 6 1731
• 3. Cobalt carbonyl as an effective CO source in one-pot synthesis of esters from aryl halides
  P. Baburajan,R. Senthilkumaran,Kuppanagounder P. Elango New J. Chem. 2013 37 3050
• 4. Pd-catalyzed direct C–H arylation of thieno[3,4-c]pyrrole-4,6-dione (TPD): a step-economical synthetic alternative to access TPD-centred symmetrical small molecules
  Shan-Yun Chang,Po-Han Lin,Ching-Yuan Liu RSC Adv. 2014 4 35868
• 5. Magnetization of graphene oxide nanosheets using nickel magnetic nanoparticles as a novel support for the fabrication of copper as a practical, selective, and reusable nanocatalyst in C–C and C–O coupling reactions
  Parisa Moradi,Maryam Hajjami RSC Adv. 2021 11 25867

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Chlorobenzenes
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Halobenzenes Chlorobenzenes
• Pesticide Chemicals Pesticide Active Ingredients Standard Substances
• Pharmaceutical and Biochemical Products Pharmaceutical Active Ingredients Standard Substances
• Solvents and Organic Chemicals Organic Compounds Organic Halides
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

• 108-37-2(1-Bromo-3-chlorobenzene)
• 1219803-83-4(1-Bromo-3,5-dichlorobenzene-d3)
• 29016-72-6(Naphthalene, 1-bromo-7-chloro-)
• 870822-84-7(2-Bromo-6-chloronaphthalene)
• 134415-42-2(4-bromochlorobenzene-d4)
• 694-80-4(1-Bromo-2-chlorobenzene)
• 19752-55-7(1-Bromo-3,5-dichlorobenzene)
• 14862-52-3(1,3-Dibromo-5-chlorobenzene)
• 18282-59-2(1-Bromo-3,4-dichlorobenzene)
• 28906-38-9(Benzene, bromochloro-)