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  Craig A. Kelly,David R. Rosseinsky Phys. Chem. Chem. Phys., 2001,3, 2086-2090
• 3. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan
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  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Tetrahydrofurans Tetrahydrofurans
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Tetrahydrofurans
• Solvents and Organic Chemicals Organic Compounds Heterocyclic Compounds

Research Brief on (S)-Tetrahydrofuran-3-ol (CAS: 86087-23-2): Recent Advances and Applications in Chemical Biology and Pharmaceutical Sciences

(S)-Tetrahydrofuran-3-ol (CAS: 86087-23-2) is a chiral building block of significant interest in chemical biology and pharmaceutical research due to its versatile applications in drug synthesis and biomolecular interactions. Recent studies have highlighted its role as a key intermediate in the synthesis of bioactive compounds, including antiviral agents, enzyme inhibitors, and other therapeutic molecules. This research brief consolidates the latest findings on the synthesis, applications, and mechanistic insights of (S)-Tetrahydrofuran-3-ol, providing a comprehensive overview for researchers in the field.

One of the most notable advancements in the synthesis of (S)-Tetrahydrofuran-3-ol involves asymmetric catalytic methods, which have significantly improved enantioselectivity and yield. A 2023 study published in the Journal of Organic Chemistry demonstrated a novel biocatalytic approach using engineered ketoreductases to achieve >99% enantiomeric excess (ee) under mild reaction conditions. This method not only enhances efficiency but also aligns with green chemistry principles by minimizing waste and energy consumption. Additionally, the study explored the scalability of this process, making it a promising candidate for industrial applications.

In pharmaceutical applications, (S)-Tetrahydrofuran-3-ol has been identified as a critical precursor in the development of protease inhibitors, particularly those targeting viral enzymes. Recent research published in Bioorganic & Medicinal Chemistry Letters revealed its incorporation into a new class of SARS-CoV-2 main protease inhibitors, where the chiral hydroxyl group of (S)-Tetrahydrofuran-3-ol was found to enhance binding affinity through hydrogen-bonding interactions with the enzyme's active site. These findings underscore the compound's potential in addressing emerging infectious diseases.

Beyond its role in drug synthesis, (S)-Tetrahydrofuran-3-ol has also been investigated for its utility in chemical biology tools. A 2024 study in ACS Chemical Biology reported its use as a modular scaffold for designing fluorescent probes that target glycosidases. The probe's selectivity and sensitivity were attributed to the stereochemistry of (S)-Tetrahydrofuran-3-ol, which mimics the natural substrate of these enzymes. This innovation opens new avenues for studying enzyme dynamics and screening inhibitors in high-throughput assays.

Despite these advancements, challenges remain in optimizing the cost-effectiveness and scalability of (S)-Tetrahydrofuran-3-ol production. Recent industry reports highlight ongoing efforts to streamline synthetic routes, including the use of continuous-flow reactors and immobilized catalysts. Furthermore, computational modeling studies are being leveraged to predict and improve the compound's reactivity in complex reaction environments, as discussed in a 2023 review in Chemical Reviews.

In conclusion, (S)-Tetrahydrofuran-3-ol (CAS: 86087-23-2) continues to be a focal point in chemical biology and pharmaceutical research, with recent studies emphasizing its synthetic versatility and therapeutic potential. Future research directions may explore its applications in personalized medicine and targeted drug delivery systems, further solidifying its importance in the field. This brief serves as a timely resource for researchers seeking to leverage the latest developments in their work.

• 4358-64-9(cis-Tetrahydrofuran-3,4-diol)
• 84976-47-6(3-Hydroxytetrahydrofuran)
• 22554-74-1(3,4-Furandiol,tetrahydro-, (3R,4R)-rel-)
• 84709-85-3((3S,4S)-Tetrahydrofuran-3,4-diol)
• 86087-24-3((3R)-oxolan-3-ol)
• 453-20-3(oxolan-3-ol)
• 104593-13-7(3-Furanol, tetrahydro-, sodium salt)
• 59727-71-8(Tetrahydrofuran-3,4-diol)
• 74217-98-4(2-Furanyl, tetrahydro-3-hydroxy-)
• 1217718-57-4((S)-(+)-3-Hydroxytetrahydrofuran-d4)