Production Method 1

21739-92-4

915095-85-1

Reaction Conditions

1.1 Reagents: Oxalyl chloride Catalysts: Dimethylformamide Solvents: Fluorobenzene ;  rt; 2 h, 21 - 25 °C
1.2 Catalysts: Aluminum chloride ;  < 25 °C

Reference

A NEW HETEROCYCLIC COMPOUND: CRYSTAL STRUCTURE AND ANTICANCER ACTIVITY AGAINST HUMAN LUNG ADENOCARCINOMA CELLS

Shi, E. H.; Wang, L. R.; Zhao, S.; Shen, L.; Zhang, C. Y.; et al, Journal of Structural Chemistry, 2020, 61(7), 1167-1174

Production Method 2

21739-92-4

915095-85-1

Reaction Conditions

1.1 Reagents: Oxalyl chloride Catalysts: Dimethylformamide ;  15 min, 12 - 25 °C; 2 h, 21 - 25 °C; 21 - 25 °C; 25 °C → 0 °C
1.2 Catalysts: Aluminum chloride ;  < 25 °C; 1 h, 23 - 25 °C
1.3 Solvents: Water

Reference

Efficient Synthesis of Empagliflozin, an Inhibitor of SGLT-2, Utilizing an AlCl3-Promoted Silane Reduction of a β-Glycopyranoside

Wang, Xiao-jun; Zhang, Li; Byrne, Denis; Nummy, Larry; Weber, Dirk; et al, Organic Letters, 2014, 16(16), 4090-4093

Production Method 3

21900-52-7

915095-85-1

Reaction Conditions

1.1 Reagents: Aluminum chloride Solvents: Dichloromethane ;  rt → 0 °C; 0 °C; 0 °C → rt; 18 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  cooled

Reference

A novel, simple and mild route for synthesis of dimer impurities of gliflozins by using PD (DBA)2

Rane, Rajesh A.; Suryawanshi, Mugdha R.; Babhulkar, Gauri V.; Male, Rohit D.; Ketkale, Sneha B.; et al, European Journal of Biomedical and Pharmaceutical Sciences, 2022, 9(10), 340-345

Production Method 4

21900-52-7

915095-85-1

Reaction Conditions

1.1 Catalysts: Aluminum chloride ;  < 25 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  5 - 25 °C

Reference

An efficient synthesis for empagliflozin (an inhibitor of SGLT-2)

Jayachandra, Sureshbabu; Sethi, Madhuresh Kumar; Kaushik, Vipin Kumar; Ravi, Vijaya Krishna; Pothani, Jayaram; et al, World Journal of Pharmacy and Pharmaceutical Sciences, 2018, 7(12), 537-545

(5-Bromo-2-chlorophenyl)(4-fluorophenyl)methanone Raw materials

• 5-bromo-2-chloro-benzoic acid
• 5-bromo-2-chlorobenzoyl chloride

(5-Bromo-2-chlorophenyl)(4-fluorophenyl)methanone Preparation Products

• (5-Bromo-2-chlorophenyl)(4-fluorophenyl)methanone (915095-85-1)

• 1. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 2. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 3. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
• 4. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 5. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782

• 1806-23-1(2-Chloro-4'-fluorobenzophenone)
• 844879-12-5(4-BROMO-3'-CHLORO-5'-FLUOROBENZOPHENONE)
• 879545-43-4((5-Bromo-2-chlorophenyl)(4-ethylphenyl)methanone)
• 135774-38-8(3-Bromo-2'-chlorobenzophenone)
• 312749-31-8((5-Bromo-2-chlorophenyl)phenylMethanone)
• 69943-47-1((2-chloro-4-fluorophenyl)(phenyl)methanone)
• 270903-87-2(2,5-Dichloro-4'-fluorobenzophenone)
• 844879-45-4(3-BROMO-3'-CHLORO-5'-FLUOROBENZOPHENONE)
• 1096342-71-0((5-Bromo-2-chlorophenyl)(4-methylphenyl)Methanone)
• 87750-61-6(Methanone,(2-chloro-4-fluorophenyl)(4-fluorophenyl)-)