Production Method 1

254454-54-1

2564-83-2

1765-93-1

1044507-64-3

398-23-2

2222044-40-6

Reaction Conditions

1.1R:(Me3Si)2NH ?Na, C:13462-90-3, C:5456-63-3, S:Me2CHOH, S:THF, 30 min, 80°C

Reference

Microwave-Assisted Suzuki-Miyaura Cross Coupling using Nickel as Catalyst to Rapidly Access to 3-Arylazetidine

By Dequirez, Geoffroy et al, ChemistrySelect, 2017, 2(28), 8841-8846

Production Method 2

254454-54-1

1765-93-1

1044507-64-3

2427990-83-6

Reaction Conditions

1.1R:Cs2CO3, C:Pd acetylacetonate, C:657408-07-6, S:p-Cymene, S:H2O, 24 h, 100°C

Reference

Synthesis of 2-Aryl Azetidines through Pd-Catalyzed Migration/Coupling of 3-Iodoazetidines and Aryl Boronic Acids

By Yang, Han et al, Organic Letters, 2022, 24(31), 5731-5735

1-Azetidinecarboxylic acid, 3-(4-fluorophenyl)-, 1,1-dimethylethyl ester Raw materials

• 1-Boc-3-iodoazetidine
• Tempo
• 4-Fluorobenzeneboronic acid

1-Azetidinecarboxylic acid, 3-(4-fluorophenyl)-, 1,1-dimethylethyl ester Preparation Products

• 4,4'-Difluorobiphenyl (398-23-2)
• 1-Azetidinecarboxylic acid, 3-(4-fluorophenyl)-, 1,1-dimethylethyl ester (1044507-64-3)
• 1-Azetidinecarboxylic acid, 3-[(2,2,6,6-tetramethyl-1-piperidinyl)oxy]-, 1,1-dimethylethyl ester (2222044-40-6)
• 1-Azetidinecarboxylic acid, 2-(4-fluorophenyl)-, 1,1-dimethylethyl ester (2427990-83-6)

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