A dual-response sensor based on NBD for the highly selective determination of sulfide in living cells and zebrafish?

New Journal of Chemistry Pub Date: 2019-01-30 DOI: 10.1039/C8NJ06352D

Abstract

A dual chemosensor, 1-NO2, based on the combination of 4-chloro-7-nitrobenzofurazan (NBD) and 1-(2-hydroxyethyl)piperazine, was applied for the detection of sulfide. Chemosensor 1-NO2 could detect sulfide through fluorescence turn-off and color change from orange to pink-red. The sensing mechanism and structure of 1-NO2 with S2? were demonstrated using Job's plot, ESI-MS analysis and theoretical calculations. In addition, 1-NO2 as a sulfide detector could be used in living organisms (HeLa cells and zebrafish).

Graphical abstract: A dual-response sensor based on NBD for the highly selective determination of sulfide in living cells and zebrafish
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